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Deviance-Related Responses along the Auditory Hierarchy: Combined FFR, MLR and MMN Evidence.
PLoS One. 2015; 10(9):e0136794.Plos

Abstract

The mismatch negativity (MMN) provides a correlate of automatic auditory discrimination in human auditory cortex that is elicited in response to violation of any acoustic regularity. Recently, deviance-related responses were found at much earlier cortical processing stages as reflected by the middle latency response (MLR) of the auditory evoked potential, and even at the level of the auditory brainstem as reflected by the frequency following response (FFR). However, no study has reported deviance-related responses in the FFR, MLR and long latency response (LLR) concurrently in a single recording protocol. Amplitude-modulated (AM) sounds were presented to healthy human participants in a frequency oddball paradigm to investigate deviance-related responses along the auditory hierarchy in the ranges of FFR, MLR and LLR. AM frequency deviants modulated the FFR, the Na and Nb components of the MLR, and the LLR eliciting the MMN. These findings demonstrate that it is possible to elicit deviance-related responses at three different levels (FFR, MLR and LLR) in one single recording protocol, highlight the involvement of the whole auditory hierarchy in deviance detection and have implications for cognitive and clinical auditory neuroscience. Moreover, the present protocol provides a new research tool into clinical neuroscience so that the functional integrity of the auditory novelty system can now be tested as a whole in a range of clinical populations where the MMN was previously shown to be defective.

Authors+Show Affiliations

Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona, Catalonia, Spain; Cognitive Neuroscience Research Group, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Catalonia, Spain; Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Fukushima, Japan.Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona, Catalonia, Spain; Cognitive Neuroscience Research Group, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Catalonia, Spain.Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona, Catalonia, Spain; Cognitive Neuroscience Research Group, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Catalonia, Spain.Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona, Catalonia, Spain; Cognitive Neuroscience Research Group, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Catalonia, Spain.Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Fukushima, Japan.Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona, Catalonia, Spain; Cognitive Neuroscience Research Group, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Catalonia, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26348628

Citation

Shiga, Tetsuya, et al. "Deviance-Related Responses Along the Auditory Hierarchy: Combined FFR, MLR and MMN Evidence." PloS One, vol. 10, no. 9, 2015, pp. e0136794.
Shiga T, Althen H, Cornella M, et al. Deviance-Related Responses along the Auditory Hierarchy: Combined FFR, MLR and MMN Evidence. PLoS One. 2015;10(9):e0136794.
Shiga, T., Althen, H., Cornella, M., Zarnowiec, K., Yabe, H., & Escera, C. (2015). Deviance-Related Responses along the Auditory Hierarchy: Combined FFR, MLR and MMN Evidence. PloS One, 10(9), e0136794. https://doi.org/10.1371/journal.pone.0136794
Shiga T, et al. Deviance-Related Responses Along the Auditory Hierarchy: Combined FFR, MLR and MMN Evidence. PLoS One. 2015;10(9):e0136794. PubMed PMID: 26348628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deviance-Related Responses along the Auditory Hierarchy: Combined FFR, MLR and MMN Evidence. AU - Shiga,Tetsuya, AU - Althen,Heike, AU - Cornella,Miriam, AU - Zarnowiec,Katarzyna, AU - Yabe,Hirooki, AU - Escera,Carles, Y1 - 2015/09/08/ PY - 2015/04/02/received PY - 2015/08/08/accepted PY - 2015/9/9/entrez PY - 2015/9/9/pubmed PY - 2016/5/19/medline SP - e0136794 EP - e0136794 JF - PloS one JO - PLoS One VL - 10 IS - 9 N2 - The mismatch negativity (MMN) provides a correlate of automatic auditory discrimination in human auditory cortex that is elicited in response to violation of any acoustic regularity. Recently, deviance-related responses were found at much earlier cortical processing stages as reflected by the middle latency response (MLR) of the auditory evoked potential, and even at the level of the auditory brainstem as reflected by the frequency following response (FFR). However, no study has reported deviance-related responses in the FFR, MLR and long latency response (LLR) concurrently in a single recording protocol. Amplitude-modulated (AM) sounds were presented to healthy human participants in a frequency oddball paradigm to investigate deviance-related responses along the auditory hierarchy in the ranges of FFR, MLR and LLR. AM frequency deviants modulated the FFR, the Na and Nb components of the MLR, and the LLR eliciting the MMN. These findings demonstrate that it is possible to elicit deviance-related responses at three different levels (FFR, MLR and LLR) in one single recording protocol, highlight the involvement of the whole auditory hierarchy in deviance detection and have implications for cognitive and clinical auditory neuroscience. Moreover, the present protocol provides a new research tool into clinical neuroscience so that the functional integrity of the auditory novelty system can now be tested as a whole in a range of clinical populations where the MMN was previously shown to be defective. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/26348628/Deviance_Related_Responses_along_the_Auditory_Hierarchy:_Combined_FFR_MLR_and_MMN_Evidence_ L2 - https://dx.plos.org/10.1371/journal.pone.0136794 DB - PRIME DP - Unbound Medicine ER -