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Inactivation of the dorsal hippocampus or the medial prefrontal cortex impairs retrieval but has differential effect on spatial memory reconsolidation.
Neurobiol Learn Mem. 2015 Nov; 125:146-51.NL

Abstract

Active memories can incorporate new information through reconsolidation. However, the notion that memory retrieval is necessary for reconsolidation has been recently challenged. Non-reinforced retrieval induces hippocampus and medial prefrontal cortex (mPFC)-dependent reconsolidation of spatial memory in the Morris water maze (MWM). We found that the effect of protein synthesis inhibition on this process is abolished when retrieval of the learned spatial preference is hindered through mPFC inactivation but not when it is blocked by deactivation of dorsal CA1. Our results do not fully agree with the hypothesis that retrieval is unneeded for reconsolidation. Instead, they support the idea that a hierarchic interaction between the hippocampus and the mPFC controls spatial memory in the MWM, and indicate that this cortex is sufficient to retrieve the information essential to reconsolidate the spatial memory trace, even when the hippocampus is inactivated.

Authors+Show Affiliations

Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, RN 59056-450, Natal, Brazil.Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, RN 59056-450, Natal, Brazil.Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, RN 59056-450, Natal, Brazil.Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, RN 59056-450, Natal, Brazil.Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, RN 59056-450, Natal, Brazil. Electronic address: martin.cammarota@neuro.ufrn.br.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26348793

Citation

Rossato, Janine I., et al. "Inactivation of the Dorsal Hippocampus or the Medial Prefrontal Cortex Impairs Retrieval but Has Differential Effect On Spatial Memory Reconsolidation." Neurobiology of Learning and Memory, vol. 125, 2015, pp. 146-51.
Rossato JI, Köhler CA, Radiske A, et al. Inactivation of the dorsal hippocampus or the medial prefrontal cortex impairs retrieval but has differential effect on spatial memory reconsolidation. Neurobiol Learn Mem. 2015;125:146-51.
Rossato, J. I., Köhler, C. A., Radiske, A., Bevilaqua, L. R., & Cammarota, M. (2015). Inactivation of the dorsal hippocampus or the medial prefrontal cortex impairs retrieval but has differential effect on spatial memory reconsolidation. Neurobiology of Learning and Memory, 125, 146-51. https://doi.org/10.1016/j.nlm.2015.09.001
Rossato JI, et al. Inactivation of the Dorsal Hippocampus or the Medial Prefrontal Cortex Impairs Retrieval but Has Differential Effect On Spatial Memory Reconsolidation. Neurobiol Learn Mem. 2015;125:146-51. PubMed PMID: 26348793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inactivation of the dorsal hippocampus or the medial prefrontal cortex impairs retrieval but has differential effect on spatial memory reconsolidation. AU - Rossato,Janine I, AU - Köhler,Cristiano A, AU - Radiske,Andressa, AU - Bevilaqua,Lia R M, AU - Cammarota,Martín, Y1 - 2015/09/05/ PY - 2014/10/23/received PY - 2015/08/10/revised PY - 2015/09/01/accepted PY - 2015/9/9/entrez PY - 2015/9/9/pubmed PY - 2016/9/10/medline KW - Anisomycin KW - Memory KW - Muscimol KW - Reactivation KW - Recall KW - Water maze SP - 146 EP - 51 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 125 N2 - Active memories can incorporate new information through reconsolidation. However, the notion that memory retrieval is necessary for reconsolidation has been recently challenged. Non-reinforced retrieval induces hippocampus and medial prefrontal cortex (mPFC)-dependent reconsolidation of spatial memory in the Morris water maze (MWM). We found that the effect of protein synthesis inhibition on this process is abolished when retrieval of the learned spatial preference is hindered through mPFC inactivation but not when it is blocked by deactivation of dorsal CA1. Our results do not fully agree with the hypothesis that retrieval is unneeded for reconsolidation. Instead, they support the idea that a hierarchic interaction between the hippocampus and the mPFC controls spatial memory in the MWM, and indicate that this cortex is sufficient to retrieve the information essential to reconsolidate the spatial memory trace, even when the hippocampus is inactivated. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/26348793/Inactivation_of_the_dorsal_hippocampus_or_the_medial_prefrontal_cortex_impairs_retrieval_but_has_differential_effect_on_spatial_memory_reconsolidation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(15)00170-7 DB - PRIME DP - Unbound Medicine ER -