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Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy.
Biomed Pharmacother. 2015 Aug; 74:145-7.BP

Abstract

Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes and remains a major cause of preventable blindness among adults at working age. DR involves an abnormal pathology of major retinal cells, including retinal pigment epithelium, microaneurysms, inter-retinal oedema, haemorrhage, exudates (hard exudates) and intraocular neovascularization. Hyperglycemia is the driving force for the development of diabetic retinopathy. The exact cause of diabetic nephropathy is unknown, but various postulated mechanisms are: hyperglycemia, advanced glycosylation products, activation of cytokines. In this review article, we have discussed a number of diabetes-induced metabolites such as glucose, advanced glycation end products, protein kinase C and oxidative stress and other related factors that are implicated in the pathophysiology of the DR. An understanding of the biochemical and molecular changes especially early in the DR may lead to new and effective therapies towards prevention and amelioration of DR.

Authors+Show Affiliations

Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.Department of Cardiology, The First Clinical Hospital of Harbin Medical University, Harbin 150086, China.Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Electronic address: learnharder@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26349976

Citation

Wan, Ting-Ting, et al. "Recent Advances in Understanding the Biochemical and Molecular Mechanism of Diabetic Retinopathy." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 74, 2015, pp. 145-7.
Wan TT, Li XF, Sun YM, et al. Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy. Biomed Pharmacother. 2015;74:145-7.
Wan, T. T., Li, X. F., Sun, Y. M., Li, Y. B., & Su, Y. (2015). Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 74, 145-7. https://doi.org/10.1016/j.biopha.2015.08.002
Wan TT, et al. Recent Advances in Understanding the Biochemical and Molecular Mechanism of Diabetic Retinopathy. Biomed Pharmacother. 2015;74:145-7. PubMed PMID: 26349976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy. AU - Wan,Ting-Ting, AU - Li,Xiu-Fen, AU - Sun,Yan-Ming, AU - Li,Yan-Bo, AU - Su,Ying, Y1 - 2015/08/13/ PY - 2015/05/02/received PY - 2015/08/02/accepted PY - 2015/9/10/entrez PY - 2015/9/10/pubmed PY - 2016/6/9/medline KW - Advanced glycation end products KW - Diabetic retinopathy KW - Hyperglycemia KW - Oxidative stress KW - Protein kinase C SP - 145 EP - 7 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 74 N2 - Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes and remains a major cause of preventable blindness among adults at working age. DR involves an abnormal pathology of major retinal cells, including retinal pigment epithelium, microaneurysms, inter-retinal oedema, haemorrhage, exudates (hard exudates) and intraocular neovascularization. Hyperglycemia is the driving force for the development of diabetic retinopathy. The exact cause of diabetic nephropathy is unknown, but various postulated mechanisms are: hyperglycemia, advanced glycosylation products, activation of cytokines. In this review article, we have discussed a number of diabetes-induced metabolites such as glucose, advanced glycation end products, protein kinase C and oxidative stress and other related factors that are implicated in the pathophysiology of the DR. An understanding of the biochemical and molecular changes especially early in the DR may lead to new and effective therapies towards prevention and amelioration of DR. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/26349976/Recent_advances_in_understanding_the_biochemical_and_molecular_mechanism_of_diabetic_retinopathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(15)00187-0 DB - PRIME DP - Unbound Medicine ER -