Tags

Type your tag names separated by a space and hit enter

Cannabidiol and Sodium Nitroprusside: Two Novel Neuromodulatory Pharmacological Interventions to Treat and Prevent Psychosis.
CNS Neurol Disord Drug Targets. 2015; 14(8):970-8.CN

Abstract

Since most patients with schizophrenia do not respond properly to treatment, scientific effort has been driven to the development of new compounds acting on pharmacological targets beyond the dopaminergic system. Therefore, the aim is to review basic and clinical research findings from studies evaluating the effects of cannabidiol (CBD), an inhibitor of the reuptake and metabolism of anandamide and several other effects on nervous system, and sodium nitroprusside, a nitric oxide donor, on the prevention and treatment of psychosis. Animal and human research supports that CBD and sodium nitroprusside might be effective in the prevention and treatment of psychosis in general and especially in schizophrenia. The evidence available to date shows that CBD and sodium nitroprusside act in pathways associated with psychotic symptoms and that they may be important agents in the management of prodromal psychotic states and psychosis. This underscores the relevance of further research on the effects of these agents and others that mediate the activity of the cannabinoid system and of nitric oxide, as well as comparative studies of their antipsychotic effects and those of other antipsychotic drugs currently used to treat schizophrenia.

Authors+Show Affiliations

Hospital das Clinicas - Terceiro Andar; Av. Bandeirantes, 3900; RibeiraoPreto -Sao Paulo, CEP - 14049-900, Brazil. jcrippa@fmrp.usp.br.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26350340

Citation

Crippa, José Alexandre, et al. "Cannabidiol and Sodium Nitroprusside: Two Novel Neuromodulatory Pharmacological Interventions to Treat and Prevent Psychosis." CNS & Neurological Disorders Drug Targets, vol. 14, no. 8, 2015, pp. 970-8.
Crippa JA, Hallak JE, Abílio VC, et al. Cannabidiol and Sodium Nitroprusside: Two Novel Neuromodulatory Pharmacological Interventions to Treat and Prevent Psychosis. CNS Neurol Disord Drug Targets. 2015;14(8):970-8.
Crippa, J. A., Hallak, J. E., Abílio, V. C., de Lacerda, A. L., & Zuardi, A. W. (2015). Cannabidiol and Sodium Nitroprusside: Two Novel Neuromodulatory Pharmacological Interventions to Treat and Prevent Psychosis. CNS & Neurological Disorders Drug Targets, 14(8), 970-8.
Crippa JA, et al. Cannabidiol and Sodium Nitroprusside: Two Novel Neuromodulatory Pharmacological Interventions to Treat and Prevent Psychosis. CNS Neurol Disord Drug Targets. 2015;14(8):970-8. PubMed PMID: 26350340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiol and Sodium Nitroprusside: Two Novel Neuromodulatory Pharmacological Interventions to Treat and Prevent Psychosis. AU - Crippa,José Alexandre, AU - Hallak,Jaime Eduardo Cecílio, AU - Abílio,Vanessa Costhek, AU - de Lacerda,Acioly Luiz Tavares, AU - Zuardi,Antonio Waldo, PY - 2015/05/29/received PY - 2015/09/05/accepted PY - 2015/9/10/entrez PY - 2015/9/10/pubmed PY - 2016/7/9/medline SP - 970 EP - 8 JF - CNS & neurological disorders drug targets JO - CNS Neurol Disord Drug Targets VL - 14 IS - 8 N2 - Since most patients with schizophrenia do not respond properly to treatment, scientific effort has been driven to the development of new compounds acting on pharmacological targets beyond the dopaminergic system. Therefore, the aim is to review basic and clinical research findings from studies evaluating the effects of cannabidiol (CBD), an inhibitor of the reuptake and metabolism of anandamide and several other effects on nervous system, and sodium nitroprusside, a nitric oxide donor, on the prevention and treatment of psychosis. Animal and human research supports that CBD and sodium nitroprusside might be effective in the prevention and treatment of psychosis in general and especially in schizophrenia. The evidence available to date shows that CBD and sodium nitroprusside act in pathways associated with psychotic symptoms and that they may be important agents in the management of prodromal psychotic states and psychosis. This underscores the relevance of further research on the effects of these agents and others that mediate the activity of the cannabinoid system and of nitric oxide, as well as comparative studies of their antipsychotic effects and those of other antipsychotic drugs currently used to treat schizophrenia. SN - 1996-3181 UR - https://www.unboundmedicine.com/medline/citation/26350340/Cannabidiol_and_Sodium_Nitroprusside:_Two_Novel_Neuromodulatory_Pharmacological_Interventions_to_Treat_and_Prevent_Psychosis_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1871-5273&volume=14&issue=8&spage=970&aulast=Crippa DB - PRIME DP - Unbound Medicine ER -