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Potential and limits of whole genome prediction of resistance to Fusarium head blight and Septoria tritici blotch in a vast Central European elite winter wheat population.
Theor Appl Genet. 2015 Dec; 128(12):2471-81.TA

Abstract

KEY MESSAGE

Fusarium head blight and Septoria tritici blotch resistances are complex traits and can be improved efficiently by genomic selection modeling main and epistatic effects. Enhancing the resistance against Fusarium head blight (FHB) and Septoria tritici blotch (STB) is of central importance for a sustainable wheat production. Our study is based on a large experimental data set of 2325 inbred lines genotyped with 12,642 SNP markers and phenotyped in multi-environmental trials for FHB and STB resistance as well as for plant height. Our objectives were to (1) investigate the impact of plant height on FHB and STB severity, (2) examine the potential of marker-assisted selection, and (3) study the prediction ability of genomic selection modeling main and epistatic effects. We observed low correlations between plant height and FHB (r = -0.15; P < 0.05) as well as STB severity (r = -0.17; P < 0.05) suggesting negligible morphological resistances. Cross-validation in combination with association mapping revealed absence of large effect QTL impeding an efficient pyramiding of different resistance loci through marker-assisted selection. The prediction ability of genomic selection was high amounting to 0.6 for FHB and 0.5 for STB resistance. Therefore, genomic selection is a promising tool to improve FHB and STB resistance in wheat.

Authors+Show Affiliations

Department of Breeding Research, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstraβe 3, Gatersleben, 06466, Stadt Seeland, Germany. mirdita@ipk-gatersleben.de.Department of Breeding Research, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstraβe 3, Gatersleben, 06466, Stadt Seeland, Germany.Department of Breeding Research, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstraβe 3, Gatersleben, 06466, Stadt Seeland, Germany.KWS Lochow GmbH, Bergen, Germany.KWS Lochow GmbH, Bergen, Germany.KWS Lochow GmbH, Bergen, Germany.Department of Breeding Research, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstraβe 3, Gatersleben, 06466, Stadt Seeland, Germany. reif@ipk-gatersleben.de.Department of Breeding Research, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstraβe 3, Gatersleben, 06466, Stadt Seeland, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26350496

Citation

Mirdita, Vilson, et al. "Potential and Limits of Whole Genome Prediction of Resistance to Fusarium Head Blight and Septoria Tritici Blotch in a Vast Central European Elite Winter Wheat Population." TAG. Theoretical and Applied Genetics. Theoretische Und Angewandte Genetik, vol. 128, no. 12, 2015, pp. 2471-81.
Mirdita V, He S, Zhao Y, et al. Potential and limits of whole genome prediction of resistance to Fusarium head blight and Septoria tritici blotch in a vast Central European elite winter wheat population. Theor Appl Genet. 2015;128(12):2471-81.
Mirdita, V., He, S., Zhao, Y., Korzun, V., Bothe, R., Ebmeyer, E., Reif, J. C., & Jiang, Y. (2015). Potential and limits of whole genome prediction of resistance to Fusarium head blight and Septoria tritici blotch in a vast Central European elite winter wheat population. TAG. Theoretical and Applied Genetics. Theoretische Und Angewandte Genetik, 128(12), 2471-81. https://doi.org/10.1007/s00122-015-2602-1
Mirdita V, et al. Potential and Limits of Whole Genome Prediction of Resistance to Fusarium Head Blight and Septoria Tritici Blotch in a Vast Central European Elite Winter Wheat Population. Theor Appl Genet. 2015;128(12):2471-81. PubMed PMID: 26350496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential and limits of whole genome prediction of resistance to Fusarium head blight and Septoria tritici blotch in a vast Central European elite winter wheat population. AU - Mirdita,Vilson, AU - He,Sang, AU - Zhao,Yusheng, AU - Korzun,Viktor, AU - Bothe,Reiner, AU - Ebmeyer,Erhard, AU - Reif,Jochen C, AU - Jiang,Yong, Y1 - 2015/09/08/ PY - 2015/05/04/received PY - 2015/08/28/accepted PY - 2015/9/10/entrez PY - 2015/9/10/pubmed PY - 2016/3/2/medline SP - 2471 EP - 81 JF - TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik JO - Theor Appl Genet VL - 128 IS - 12 N2 - KEY MESSAGE: Fusarium head blight and Septoria tritici blotch resistances are complex traits and can be improved efficiently by genomic selection modeling main and epistatic effects. Enhancing the resistance against Fusarium head blight (FHB) and Septoria tritici blotch (STB) is of central importance for a sustainable wheat production. Our study is based on a large experimental data set of 2325 inbred lines genotyped with 12,642 SNP markers and phenotyped in multi-environmental trials for FHB and STB resistance as well as for plant height. Our objectives were to (1) investigate the impact of plant height on FHB and STB severity, (2) examine the potential of marker-assisted selection, and (3) study the prediction ability of genomic selection modeling main and epistatic effects. We observed low correlations between plant height and FHB (r = -0.15; P < 0.05) as well as STB severity (r = -0.17; P < 0.05) suggesting negligible morphological resistances. Cross-validation in combination with association mapping revealed absence of large effect QTL impeding an efficient pyramiding of different resistance loci through marker-assisted selection. The prediction ability of genomic selection was high amounting to 0.6 for FHB and 0.5 for STB resistance. Therefore, genomic selection is a promising tool to improve FHB and STB resistance in wheat. SN - 1432-2242 UR - https://www.unboundmedicine.com/medline/citation/26350496/Potential_and_limits_of_whole_genome_prediction_of_resistance_to_Fusarium_head_blight_and_Septoria_tritici_blotch_in_a_vast_Central_European_elite_winter_wheat_population_ L2 - https://dx.doi.org/10.1007/s00122-015-2602-1 DB - PRIME DP - Unbound Medicine ER -