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Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release.

Abstract

Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

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  • Authors+Show Affiliations

    ,

    School of Chemical and Biological Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China ; College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

    ,

    College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

    ,

    College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

    ,

    College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

    ,

    College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

    ,

    Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5001, Australia.

    College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

    Source

    BioMed research international 2015: 2015 pg 236745

    MeSH

    Calorimetry, Differential Scanning
    Delayed-Action Preparations
    Drug Delivery Systems
    Hydrogels
    Hydrogen-Ion Concentration
    Microscopy, Electron, Scanning
    Peptides
    Polymers
    Polyvinyl Alcohol
    Propylamines
    Silanes
    Sodium Chloride
    Spectroscopy, Fourier Transform Infrared
    Temperature

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26351630

    Citation

    TY - JOUR T1 - Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release. AU - Lu,Jingqiong, AU - Li,Yinhui, AU - Hu,Deng, AU - Chen,Xiaoling, AU - Liu,Yongmei, AU - Wang,Liping, AU - Zhao,Yansheng, Y1 - 2015/08/09/ PY - 2015/02/27/received PY - 2015/06/09/revised PY - 2015/06/16/accepted PY - 2015/9/10/entrez PY - 2015/9/10/pubmed PY - 2016/6/10/medline SP - 236745 EP - 236745 JF - BioMed research international JO - Biomed Res Int VL - 2015 N2 - Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/26351630/Synthesis_and_Properties_of_pH__Thermo__and_Salt_Sensitive_Modified_Poly_aspartic_acid_/Poly_vinyl_alcohol__IPN_Hydrogel_and_Its_Drug_Controlled_Release_ L2 - https://dx.doi.org/10.1155/2015/236745 ER -