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Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide-Au nanomaterials.
Mater Sci Eng C Mater Biol Appl. 2015 Dec 01; 57:197-204.MS

Abstract

A sensitive electrochemical sensor has been fabricated to detect Isoniazid (INZ) using reduced graphene oxide (RGO) and Au nanocomposites (RGO-Au). RGO-Au nanocomposites were synthesized by a solution-based approach of chemical co-reduction of Au(III) and graphene oxide (GO), and were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, and Fourier transform infrared (FT-IR). The Au nanoparticles separate the RGO sheets in the precipitate and prevent RGO sheets from aggregation upon π-π stacking interactions. RGO-Au nanocomposites were used to modify the glassy carbon electrode (GCE). The electrochemical properties of RGO-Au/GCE were investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), and the RGO-Au/GCE exhibited remarkably strong electrocatalytic activities towards INZ. Under the optimized conditions, there was linear relationships between the peak currents and the concentrations in the range of 1.0×10(-7)M to 1.0×10(-3)M for INZ, with the limit of detection (LOD) (based on S/N=3) of 1.0×10(-8)M for INZ.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Guo Z
Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China. Electronic address: guozhuochina@syuct.edu.cn.
Wang ZY
Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.
Wang HH
Shagang School of Iron and Steel, Soochow University, Suzhou 215021, China. Electronic address: hhwang@suda.edu.cn.
Huang GQ
Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.
Li MM
Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.

MeSH

Biosensing TechniquesCarbonConductometryEquipment DesignEquipment Failure AnalysisGlassGoldGraphiteIsoniazidMetal NanoparticlesMicroelectrodesNanocompositesOxidation-ReductionOxidesReproducibility of ResultsSensitivity and Specificity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26354255

Citation

Guo, Zhuo, et al. "Electrochemical Sensor for Isoniazid Based On the Glassy Carbon Electrode Modified With Reduced Graphene oxide-Au Nanomaterials." Materials Science & Engineering. C, Materials for Biological Applications, vol. 57, 2015, pp. 197-204.
Guo Z, Wang ZY, Wang HH, et al. Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide-Au nanomaterials. Mater Sci Eng C Mater Biol Appl. 2015;57:197-204.
Guo, Z., Wang, Z. Y., Wang, H. H., Huang, G. Q., & Li, M. M. (2015). Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide-Au nanomaterials. Materials Science & Engineering. C, Materials for Biological Applications, 57, 197-204. https://doi.org/10.1016/j.msec.2015.07.045
Guo Z, et al. Electrochemical Sensor for Isoniazid Based On the Glassy Carbon Electrode Modified With Reduced Graphene oxide-Au Nanomaterials. Mater Sci Eng C Mater Biol Appl. 2015 Dec 1;57:197-204. PubMed PMID: 26354255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide-Au nanomaterials. AU - Guo,Zhuo, AU - Wang,Ze-Yu, AU - Wang,Hui-Hua, AU - Huang,Guo-Qing, AU - Li,Meng-Meng, Y1 - 2015/07/27/ PY - 2015/02/15/received PY - 2015/06/18/revised PY - 2015/07/22/accepted PY - 2015/9/11/entrez PY - 2015/9/12/pubmed PY - 2016/6/9/medline KW - Au nanoparticles KW - Electrochemical sensor KW - Isoniazid KW - Reduced graphene oxide SP - 197 EP - 204 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 57 N2 - A sensitive electrochemical sensor has been fabricated to detect Isoniazid (INZ) using reduced graphene oxide (RGO) and Au nanocomposites (RGO-Au). RGO-Au nanocomposites were synthesized by a solution-based approach of chemical co-reduction of Au(III) and graphene oxide (GO), and were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, and Fourier transform infrared (FT-IR). The Au nanoparticles separate the RGO sheets in the precipitate and prevent RGO sheets from aggregation upon π-π stacking interactions. RGO-Au nanocomposites were used to modify the glassy carbon electrode (GCE). The electrochemical properties of RGO-Au/GCE were investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), and the RGO-Au/GCE exhibited remarkably strong electrocatalytic activities towards INZ. Under the optimized conditions, there was linear relationships between the peak currents and the concentrations in the range of 1.0×10(-7)M to 1.0×10(-3)M for INZ, with the limit of detection (LOD) (based on S/N=3) of 1.0×10(-8)M for INZ. SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/26354255/Electrochemical_sensor_for_Isoniazid_based_on_the_glassy_carbon_electrode_modified_with_reduced_graphene_oxide_Au_nanomaterials_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓6]

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