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Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women.

Abstract

BACKGROUND

Higher intake of certain vitamins may protect against cochlear damage from vascular compromise and oxidative stress, thereby reducing risk of acquired hearing loss, but data are limited.

OBJECTIVE

We prospectively examined the relation between carotenoids, vitamin A, vitamin C, vitamin E, and folate intake and risk of self-reported hearing loss in women.

DESIGN

This prospective cohort study followed 65,521 women in the Nurses' Health Study II from 1991 to 2009. Baseline and updated information obtained from validated biennial questionnaires was used in Cox proportional hazards regression models to examine independent associations between nutrient intake and self-reported hearing loss.

RESULTS

After 1,084,598 person-years of follow-up, 12,789 cases of incident hearing loss were reported. After multivariable adjustment, we observed modest but statistically significant inverse associations between higher intake of β-carotene and β-cryptoxanthin and risk of hearing loss. In comparison with women in the lowest quintile of intake, the multivariable-adjusted RR of hearing loss among women in the highest quintile was 0.88 (95% CI: 0.81, 0.94; P-trend < 0.001) for β-carotene and 0.90 (95% CI: 0.84, 0.96; P-trend < 0.001) for β-cryptoxanthin. In comparison with women with folate intake 200-399 μg/d, very low folate intake (<200 μg/d) was associated with higher risk (RR: 1.19; 95% CI: 1.01, 1.41), and higher intake tended to be associated with lower risk (P-trend = 0.04). No significant associations were observed for intakes of other carotenoids or vitamin A. Higher vitamin C intake was associated with higher risk; in comparison with women with intake <75 mg/d, the RR among women with vitamin C intake ≥1000 mg/d (mainly supplemental) was 1.22 (95% CI: 1.06, 1.42; P-trend = 0.02). There was no significant trend between intake of vitamin E intake and risk.

CONCLUSION

Higher intakes of β-carotene, β-cryptoxanthin, and folate, whether total or from diet, are associated with lower risk of hearing loss, whereas higher vitamin C intake is associated with higher risk.

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  • Authors+Show Affiliations

    ,

    Channing Division of Network Medicine and Harvard Medical School, Boston MA scurhan@partners.org.

    ,

    Eaton-Peabody Laboratories and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA; Department of Otology and Laryngology, Harvard Medical School, Boston, MA; Program in Speech and Hearing Bioscience and Technology, Division of Health Science and Technology, Harvard and Massachusetts Institute of Technology, Boston, MA;

    ,

    Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University School of Medicine, Nashville, TN; and.

    ,

    Channing Division of Network Medicine and Departments of Biostatistics and Epidemiology, Harvard School of Public Health, Boston, MA.

    ,

    Channing Division of Network Medicine and Epidemiology, Harvard School of Public Health, Boston, MA.

    Channing Division of Network Medicine and Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Epidemiology, Harvard School of Public Health, Boston, MA, Harvard Medical School, Boston MA.

    Source

    MeSH

    Adult
    Ascorbic Acid
    Cohort Studies
    Cryptoxanthins
    Diet
    Dietary Supplements
    Female
    Folic Acid
    Follow-Up Studies
    Food, Fortified
    Hearing Loss
    Humans
    Nurses
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Self Report
    United States
    Vitamin A
    Vitamin E
    Young Adult
    beta Carotene

    Pub Type(s)

    Journal Article
    Observational Study
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26354537

    Citation

    Curhan, Sharon G., et al. "Carotenoids, Vitamin A, Vitamin C, Vitamin E, and Folate and Risk of Self-reported Hearing Loss in Women." The American Journal of Clinical Nutrition, vol. 102, no. 5, 2015, pp. 1167-75.
    Curhan SG, Stankovic KM, Eavey RD, et al. Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women. Am J Clin Nutr. 2015;102(5):1167-75.
    Curhan, S. G., Stankovic, K. M., Eavey, R. D., Wang, M., Stampfer, M. J., & Curhan, G. C. (2015). Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women. The American Journal of Clinical Nutrition, 102(5), pp. 1167-75. doi:10.3945/ajcn.115.109314.
    Curhan SG, et al. Carotenoids, Vitamin A, Vitamin C, Vitamin E, and Folate and Risk of Self-reported Hearing Loss in Women. Am J Clin Nutr. 2015;102(5):1167-75. PubMed PMID: 26354537.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women. AU - Curhan,Sharon G, AU - Stankovic,Konstantina M, AU - Eavey,Roland D, AU - Wang,Molin, AU - Stampfer,Meir J, AU - Curhan,Gary C, Y1 - 2015/09/09/ PY - 2015/02/13/received PY - 2015/08/04/accepted PY - 2015/9/11/entrez PY - 2015/9/12/pubmed PY - 2016/2/9/medline KW - aging KW - carotenoids KW - epidemiology KW - hearing loss KW - vitamins SP - 1167 EP - 75 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 102 IS - 5 N2 - BACKGROUND: Higher intake of certain vitamins may protect against cochlear damage from vascular compromise and oxidative stress, thereby reducing risk of acquired hearing loss, but data are limited. OBJECTIVE: We prospectively examined the relation between carotenoids, vitamin A, vitamin C, vitamin E, and folate intake and risk of self-reported hearing loss in women. DESIGN: This prospective cohort study followed 65,521 women in the Nurses' Health Study II from 1991 to 2009. Baseline and updated information obtained from validated biennial questionnaires was used in Cox proportional hazards regression models to examine independent associations between nutrient intake and self-reported hearing loss. RESULTS: After 1,084,598 person-years of follow-up, 12,789 cases of incident hearing loss were reported. After multivariable adjustment, we observed modest but statistically significant inverse associations between higher intake of β-carotene and β-cryptoxanthin and risk of hearing loss. In comparison with women in the lowest quintile of intake, the multivariable-adjusted RR of hearing loss among women in the highest quintile was 0.88 (95% CI: 0.81, 0.94; P-trend < 0.001) for β-carotene and 0.90 (95% CI: 0.84, 0.96; P-trend < 0.001) for β-cryptoxanthin. In comparison with women with folate intake 200-399 μg/d, very low folate intake (<200 μg/d) was associated with higher risk (RR: 1.19; 95% CI: 1.01, 1.41), and higher intake tended to be associated with lower risk (P-trend = 0.04). No significant associations were observed for intakes of other carotenoids or vitamin A. Higher vitamin C intake was associated with higher risk; in comparison with women with intake <75 mg/d, the RR among women with vitamin C intake ≥1000 mg/d (mainly supplemental) was 1.22 (95% CI: 1.06, 1.42; P-trend = 0.02). There was no significant trend between intake of vitamin E intake and risk. CONCLUSION: Higher intakes of β-carotene, β-cryptoxanthin, and folate, whether total or from diet, are associated with lower risk of hearing loss, whereas higher vitamin C intake is associated with higher risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/26354537/Carotenoids_vitamin_A_vitamin_C_vitamin_E_and_folate_and_risk_of_self_reported_hearing_loss_in_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.109314 DB - PRIME DP - Unbound Medicine ER -