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Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration.
Ophthalmology 2015; 122(11):2286-94O

Abstract

PURPOSE

Unhealthy lifestyles have been associated with increased odds for age-related macular degeneration (AMD). Whether this association is modified by genetic risk for AMD is unknown and was investigated.

DESIGN

Interactions between healthy lifestyles AMD risk genotypes were studied in relation to the prevalence of AMD, assessed 6 years later.

PARTICIPANTS

Women 50 to 79 years of age in the Carotenoids in Age-Related Eye Disease Study with exposure and AMD data (n=1663).

METHODS

Healthy lifestyle scores (0-6 points) were assigned based on Healthy Eating Index scores, physical activity (metabolic equivalent of task hours/week), and smoking pack years assessed in 1994 and 1998. Genetic risk was based on Y402H in complement factor H (CFH) and A69S in age-related maculopathy susceptibility locus 2 (ARMS2). Additive and multiplicative interactions in odds ratios were assessed using the synergy index and a multiplicative interaction term, respectively.

MAIN OUTCOME MEASURES

AMD presence and severity were assessed from grading of stereoscopic fundus photographs taken in 2001-2004. AMD was present in 337 women, 91% of whom had early AMD.

RESULTS

The odds of AMD were 3.3 times greater (95% confidence interval [CI], 1.8-6.1) in women with both low healthy lifestyle score (0-2) and high-risk CFH genotype (CC), relative to those who had low genetic risk (TT) and high healthy lifestyle scores (4-6). There were no significant additive (synergy index [SI], 1.08; 95% CI, 0.70-1.67) or multiplicative (Pinteraction=0.94) interactions in the full sample. However, when limiting the sample to women with stable diets before AMD assessment (n=728) the odds for AMD associated with low healthy lifestyle scores and high-risk CFH genotype were strengthened (odds ratio, 4.6; 95% CI, 1.8-11.6) and the synergy index was significant (SI, 1.34; 95% CI, 1.05-1.70). Adjusting for dietary lutein and zeaxanthin attenuated, and therefore partially explained, the joint association. There were no significant additive or multiplicative interactions for ARMS2 and lifestyle score.

CONCLUSIONS

Having unhealthy lifestyles and 2 CFH risk alleles increased AMD risk (primarily in the early stages), in an or additive or greater (synergistic) manner. However, unhealthy lifestyles increased AMD risk regardless of AMD risk genotype.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.Department of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, New York.Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio.Department of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.Jean Mayer USDA Human Nutrition, Research Center on Aging, Tufts University, Boston, Massachusetts.Department of Neuroscience, University of Texas, Austin, Texas.Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon.Department of Ophthalmology & Visual Sciences, University of Iowa Hospital & Clinics, Iowa City, Iowa.Department of Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Obstetrics & Gynecology, School of Medicine & Public Health, University of Wisconsin, Madison, Wisconsin.Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa.Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa.Department of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Electronic address: jmarespe@wisc.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26354764

Citation

Meyers, Kristin J., et al. "Joint Associations of Diet, Lifestyle, and Genes With Age-Related Macular Degeneration." Ophthalmology, vol. 122, no. 11, 2015, pp. 2286-94.
Meyers KJ, Liu Z, Millen AE, et al. Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration. Ophthalmology. 2015;122(11):2286-94.
Meyers, K. J., Liu, Z., Millen, A. E., Iyengar, S. K., Blodi, B. A., Johnson, E., ... Mares, J. A. (2015). Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration. Ophthalmology, 122(11), pp. 2286-94. doi:10.1016/j.ophtha.2015.07.029.
Meyers KJ, et al. Joint Associations of Diet, Lifestyle, and Genes With Age-Related Macular Degeneration. Ophthalmology. 2015;122(11):2286-94. PubMed PMID: 26354764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration. AU - Meyers,Kristin J, AU - Liu,Zhe, AU - Millen,Amy E, AU - Iyengar,Sudha K, AU - Blodi,Barbara A, AU - Johnson,Elizabeth, AU - Snodderly,D Max, AU - Klein,Michael L, AU - Gehrs,Karen M, AU - Tinker,Lesley, AU - Sarto,Gloria E, AU - Robinson,Jennifer, AU - Wallace,Robert B, AU - Mares,Julie A, Y1 - 2015/09/06/ PY - 2014/08/25/received PY - 2015/07/23/revised PY - 2015/07/27/accepted PY - 2015/9/11/entrez PY - 2015/9/12/pubmed PY - 2016/2/5/medline SP - 2286 EP - 94 JF - Ophthalmology JO - Ophthalmology VL - 122 IS - 11 N2 - PURPOSE: Unhealthy lifestyles have been associated with increased odds for age-related macular degeneration (AMD). Whether this association is modified by genetic risk for AMD is unknown and was investigated. DESIGN: Interactions between healthy lifestyles AMD risk genotypes were studied in relation to the prevalence of AMD, assessed 6 years later. PARTICIPANTS: Women 50 to 79 years of age in the Carotenoids in Age-Related Eye Disease Study with exposure and AMD data (n=1663). METHODS: Healthy lifestyle scores (0-6 points) were assigned based on Healthy Eating Index scores, physical activity (metabolic equivalent of task hours/week), and smoking pack years assessed in 1994 and 1998. Genetic risk was based on Y402H in complement factor H (CFH) and A69S in age-related maculopathy susceptibility locus 2 (ARMS2). Additive and multiplicative interactions in odds ratios were assessed using the synergy index and a multiplicative interaction term, respectively. MAIN OUTCOME MEASURES: AMD presence and severity were assessed from grading of stereoscopic fundus photographs taken in 2001-2004. AMD was present in 337 women, 91% of whom had early AMD. RESULTS: The odds of AMD were 3.3 times greater (95% confidence interval [CI], 1.8-6.1) in women with both low healthy lifestyle score (0-2) and high-risk CFH genotype (CC), relative to those who had low genetic risk (TT) and high healthy lifestyle scores (4-6). There were no significant additive (synergy index [SI], 1.08; 95% CI, 0.70-1.67) or multiplicative (Pinteraction=0.94) interactions in the full sample. However, when limiting the sample to women with stable diets before AMD assessment (n=728) the odds for AMD associated with low healthy lifestyle scores and high-risk CFH genotype were strengthened (odds ratio, 4.6; 95% CI, 1.8-11.6) and the synergy index was significant (SI, 1.34; 95% CI, 1.05-1.70). Adjusting for dietary lutein and zeaxanthin attenuated, and therefore partially explained, the joint association. There were no significant additive or multiplicative interactions for ARMS2 and lifestyle score. CONCLUSIONS: Having unhealthy lifestyles and 2 CFH risk alleles increased AMD risk (primarily in the early stages), in an or additive or greater (synergistic) manner. However, unhealthy lifestyles increased AMD risk regardless of AMD risk genotype. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/26354764/Joint_Associations_of_Diet_Lifestyle_and Genes_with_Age_Related_Macular Degeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(15)00767-8 DB - PRIME DP - Unbound Medicine ER -