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Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis.
Int J Cancer 2016; 138(8):1843-50IJ

Abstract

While several epidemiological studies have investigated the association between vitamin C and risk of esophageal cancer, the results remain inconsistent. In the present study, a meta-analysis was conducted to assess the impact of dietary vitamin C intake on esophageal cancer risk. Online databases were searched up to March 29, 2015, for studies on the association between dietary vitamin C intake and esophageal cancer risk. Pooled risk ratios (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Dose-response analyses were performed using the method of restricted cubic splines with four knots at percentiles of 5, 35, 65 and 95% of the distribution. Publication bias was estimated using Egger's tests and funnel plots. In all, 15 articles were included in this meta-analysis, including 20 studies, containing 7063 controls and 3955 cases of esophageal cancer. By comparing the highest vs. the lowest categories of vitamin C intake, we found that vitamin C was inversely associated with the risk of esophageal cancer [overall OR = 0.58, 95% CI = 0.49-0.68, I(2) = 56%]. A linear dose-response relationship was found. With an increase in dietary vitamin C intake of 50 mg/day, the risk of esophageal cancer statistically decreased by 13% (OR = 0.87, 95% CI = 0.80-0.93, p(linearity) = 0.0002). In conclusion, our analysis suggested that the higher intake of dietary vitamin C might have a protective effect against esophageal cancer.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China.The North Hospital of the Ninth People's Hospital of Shanghai City, Shanghai, 201999, China.Henan Tumor Hospital, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China.Henan Tumor Hospital, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China.Henan Tumor Hospital, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China.Henan Tumor Hospital, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China.Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China.Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26355388

Citation

Bo, Yacong, et al. "Association Between Dietary Vitamin C Intake and Risk of Esophageal Cancer: a Dose-response Meta-analysis." International Journal of Cancer, vol. 138, no. 8, 2016, pp. 1843-50.
Bo Y, Lu Y, Zhao Y, et al. Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis. Int J Cancer. 2016;138(8):1843-50.
Bo, Y., Lu, Y., Zhao, Y., Zhao, E., Yuan, L., Lu, W., ... Lu, Q. (2016). Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis. International Journal of Cancer, 138(8), pp. 1843-50. doi:10.1002/ijc.29838.
Bo Y, et al. Association Between Dietary Vitamin C Intake and Risk of Esophageal Cancer: a Dose-response Meta-analysis. Int J Cancer. 2016 Apr 15;138(8):1843-50. PubMed PMID: 26355388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis. AU - Bo,Yacong, AU - Lu,Yan, AU - Zhao,Yan, AU - Zhao,Erjiang, AU - Yuan,Ling, AU - Lu,Weiquan, AU - Cui,Lingling, AU - Lu,Quanjun, Y1 - 2015/10/15/ PY - 2015/07/24/received PY - 2015/09/01/accepted PY - 2015/9/11/entrez PY - 2015/9/12/pubmed PY - 2016/6/21/medline KW - dietary vitamin C KW - dose-response KW - esophageal cancer KW - intake KW - meta-analysis SP - 1843 EP - 50 JF - International journal of cancer JO - Int. J. Cancer VL - 138 IS - 8 N2 - While several epidemiological studies have investigated the association between vitamin C and risk of esophageal cancer, the results remain inconsistent. In the present study, a meta-analysis was conducted to assess the impact of dietary vitamin C intake on esophageal cancer risk. Online databases were searched up to March 29, 2015, for studies on the association between dietary vitamin C intake and esophageal cancer risk. Pooled risk ratios (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Dose-response analyses were performed using the method of restricted cubic splines with four knots at percentiles of 5, 35, 65 and 95% of the distribution. Publication bias was estimated using Egger's tests and funnel plots. In all, 15 articles were included in this meta-analysis, including 20 studies, containing 7063 controls and 3955 cases of esophageal cancer. By comparing the highest vs. the lowest categories of vitamin C intake, we found that vitamin C was inversely associated with the risk of esophageal cancer [overall OR = 0.58, 95% CI = 0.49-0.68, I(2) = 56%]. A linear dose-response relationship was found. With an increase in dietary vitamin C intake of 50 mg/day, the risk of esophageal cancer statistically decreased by 13% (OR = 0.87, 95% CI = 0.80-0.93, p(linearity) = 0.0002). In conclusion, our analysis suggested that the higher intake of dietary vitamin C might have a protective effect against esophageal cancer. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/26355388/Association_between_dietary_vitamin_C_intake_and_risk_of_esophageal_cancer:_A_dose_response_meta_analysis_ L2 - https://doi.org/10.1002/ijc.29838 DB - PRIME DP - Unbound Medicine ER -