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"ADAM complex" (amniotic deformity, adhesions, mutilations)--a pattern of craniofacial and limb defects.
Am J Med Genet. 1978; 2(1):81-98.AJ

Abstract

We report eight patients with the craniofacial defects and limb anomalies of the (amniotic deformity, adhesions, mutilations) ADAM complex. Facial abnormalities comprise clefts and distortion and dislocation of craniofacial structures; limbs show various combinations of amputation, secondary syndactyly, and constriction. From previous reports and our cases it is obvious that the clinical picture of the ADAM complex varies enormously; a less severe type combines cleft lip and palate with amputations or amniotic bands. Clinical and experimental data suggest that these malformations are of symptomatic (exogenous) origin. Nosologic differentiation from other conditions phenotypically similar but of genetic etiology is important for genetic counseling. Observation of the ADAM complex in two members of a family suggests that genetic factors might operate in some cases.

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Authors

Keller H
No affiliation info available
Neuhauser G
No affiliation info available
Durkin-Stamm MV
No affiliation info available
Kaveggia EG
No affiliation info available
Schaaff A
No affiliation info available
Sitzmann F
No affiliation info available

MeSH

Abnormalities, MultipleAmniotic Band SyndromeChildEncephaloceleFaceFemaleHumansInfantInfant, NewbornLimb Deformities, CongenitalMaleSkull

Pub Type(s)

Journal Article

Language

eng

PubMed ID

263584

Citation

Keller, H, et al. ""ADAM Complex" (amniotic Deformity, Adhesions, Mutilations)--a Pattern of Craniofacial and Limb Defects." American Journal of Medical Genetics, vol. 2, no. 1, 1978, pp. 81-98.
Keller H, Neuhauser G, Durkin-Stamm MV, et al. "ADAM complex" (amniotic deformity, adhesions, mutilations)--a pattern of craniofacial and limb defects. Am J Med Genet. 1978;2(1):81-98.
Keller, H., Neuhauser, G., Durkin-Stamm, M. V., Kaveggia, E. G., Schaaff, A., & Sitzmann, F. (1978). "ADAM complex" (amniotic deformity, adhesions, mutilations)--a pattern of craniofacial and limb defects. American Journal of Medical Genetics, 2(1), 81-98.
Keller H, et al. "ADAM Complex" (amniotic Deformity, Adhesions, Mutilations)--a Pattern of Craniofacial and Limb Defects. Am J Med Genet. 1978;2(1):81-98. PubMed PMID: 263584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - "ADAM complex" (amniotic deformity, adhesions, mutilations)--a pattern of craniofacial and limb defects. AU - Keller,H, AU - Neuhauser,G, AU - Durkin-Stamm,M V, AU - Kaveggia,E G, AU - Schaaff,A, AU - Sitzmann,F, PY - 1978/1/1/pubmed PY - 1978/1/1/medline PY - 1978/1/1/entrez SP - 81 EP - 98 JF - American journal of medical genetics JO - Am J Med Genet VL - 2 IS - 1 N2 - We report eight patients with the craniofacial defects and limb anomalies of the (amniotic deformity, adhesions, mutilations) ADAM complex. Facial abnormalities comprise clefts and distortion and dislocation of craniofacial structures; limbs show various combinations of amputation, secondary syndactyly, and constriction. From previous reports and our cases it is obvious that the clinical picture of the ADAM complex varies enormously; a less severe type combines cleft lip and palate with amputations or amniotic bands. Clinical and experimental data suggest that these malformations are of symptomatic (exogenous) origin. Nosologic differentiation from other conditions phenotypically similar but of genetic etiology is important for genetic counseling. Observation of the ADAM complex in two members of a family suggests that genetic factors might operate in some cases. SN - 0148-7299 UR - https://www.unboundmedicine.com/medline/citation/263584/"ADAM_complex"__amniotic_deformity_adhesions_mutilations___a_pattern_of_craniofacial_and_limb_defects_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0148-7299&date=1978&volume=2&issue=1&spage=81 DB - PRIME DP - Unbound Medicine ER -