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Association between vitamin C intake and the risk of pancreatic cancer: a meta-analysis of observational studies.

Abstract

Quantification of the association between the intake of vitamin C and risk of pancreatic cancer is still conflicting. We therefore conducted a meta-analysis to assess the association between them. Pertinent studies were identified by a search of PubMed and Web of Knowledge throughSeptember of 2014. A random effects model was used to combine the data for analysis. Sensitivity analysis and publication bias were conducted. Data from 17 studies including 4827 pancreatic cancer cases were used in this meta-analysis. Pooled results suggested that highest vitamin C intake amount versus lowest amount was significantlyassociated with reduced the risk of pancreatic cancer [summary relative risk (RR) = 0.705, 95% CI = 0.612-0.811, I(2) = 42.3%]. The associations were also significant both in Caucasian [summary RR = 0.741, 95% CI = 0.626-0.876], Asian [summary RR = 0.455, 95% CI = 0.275-0.754] and Mixed population [summary RR = 0.677, 95% CI = 0.508-0.901]. No publication bias was found. Our analysis suggested that the higher intake of vitamin C might reduce the risk of pancreatic cancer.

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  • Authors+Show Affiliations

    ,

    Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

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    Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

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    Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

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    Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

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    Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

    ,

    Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

    Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

    Source

    Scientific reports 5: 2015 Sep 11 pg 13973

    MeSH

    Ascorbic Acid
    Diet
    Humans
    Pancreatic Neoplasms
    Publication Bias
    Risk

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    26360104

    Citation

    Fan, Hua, et al. "Association Between Vitamin C Intake and the Risk of Pancreatic Cancer: a Meta-analysis of Observational Studies." Scientific Reports, vol. 5, 2015, p. 13973.
    Fan H, Kou J, Han D, et al. Association between vitamin C intake and the risk of pancreatic cancer: a meta-analysis of observational studies. Sci Rep. 2015;5:13973.
    Fan, H., Kou, J., Han, D., Li, P., Zhang, D., Wu, Q., & He, Q. (2015). Association between vitamin C intake and the risk of pancreatic cancer: a meta-analysis of observational studies. Scientific Reports, 5, p. 13973. doi:10.1038/srep13973.
    Fan H, et al. Association Between Vitamin C Intake and the Risk of Pancreatic Cancer: a Meta-analysis of Observational Studies. Sci Rep. 2015 Sep 11;5:13973. PubMed PMID: 26360104.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between vitamin C intake and the risk of pancreatic cancer: a meta-analysis of observational studies. AU - Fan,Hua, AU - Kou,Jiantao, AU - Han,Dongdong, AU - Li,Ping, AU - Zhang,Dong, AU - Wu,Qiao, AU - He,Qiang, Y1 - 2015/09/11/ PY - 2014/12/03/received PY - 2015/08/12/accepted PY - 2015/9/12/entrez PY - 2015/9/12/pubmed PY - 2016/8/11/medline SP - 13973 EP - 13973 JF - Scientific reports JO - Sci Rep VL - 5 N2 - Quantification of the association between the intake of vitamin C and risk of pancreatic cancer is still conflicting. We therefore conducted a meta-analysis to assess the association between them. Pertinent studies were identified by a search of PubMed and Web of Knowledge throughSeptember of 2014. A random effects model was used to combine the data for analysis. Sensitivity analysis and publication bias were conducted. Data from 17 studies including 4827 pancreatic cancer cases were used in this meta-analysis. Pooled results suggested that highest vitamin C intake amount versus lowest amount was significantlyassociated with reduced the risk of pancreatic cancer [summary relative risk (RR) = 0.705, 95% CI = 0.612-0.811, I(2) = 42.3%]. The associations were also significant both in Caucasian [summary RR = 0.741, 95% CI = 0.626-0.876], Asian [summary RR = 0.455, 95% CI = 0.275-0.754] and Mixed population [summary RR = 0.677, 95% CI = 0.508-0.901]. No publication bias was found. Our analysis suggested that the higher intake of vitamin C might reduce the risk of pancreatic cancer. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/26360104/Association_between_vitamin_C_intake_and_the_risk_of_pancreatic_cancer:_a_meta_analysis_of_observational_studies_ L2 - http://dx.doi.org/10.1038/srep13973 DB - PRIME DP - Unbound Medicine ER -