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450 IU versus 600 IU gonadotropin for controlled ovarian stimulation in poor responders: a randomized controlled trial.
Fertil Steril. 2015 Dec; 104(6):1419-25.FS

Abstract

OBJECTIVE

To compare the outcomes of controlled ovarian stimulation/in vitro fertilization cycles using 450 IU and 600 IU gonadotropin per day in women at risk of poor ovarian response.

DESIGN

Prospective randomized controlled nonblinded study.

SETTING

University-affiliated private IVF center.

PATIENT(S)

Women considered to be at risk of poor ovarian response: aged <41 years with basal FSH >10 IU/L, antimüllerian hormone <1 ng/mL, antral follicle count ≤ 8, or a previous IVF cycle with ≥ 300 IU/d gonadotropin that resulted in a cancellation, <8 follicles, or <5 oocytes.

INTERVENTION(S)

A total of 356 patients underwent a microdose GnRH agonist flare-up IVF/intracytoplasmic sperm injection protocol with a fixed daily dose of either 450 IU FSH (n = 176) or 600 IU FSH (n = 180) equally divided between Menopur and Bravelle.

MAIN OUTCOME MEASURE(S)

Number of mature oocytes retrieved.

RESULT(S)

The two groups were similar in terms of age, ovarian reserve, cause of infertility, duration of stimulation, and cycle cancellation rate. There were no significant differences in the number of metaphase II oocytes retrieved (4 [range 0-6] vs. 4 [range 2-7]), fertilization rate (62.4% vs. 57.0%), biochemical pregnancy rate (20.5% vs. 22.9%), clinical pregnancy rate (16.4% vs. 18.3%), and implantation rate (29.8% vs. 30.4%) between the 450 IU and 600 IU groups, respectively.

CONCLUSION(S)

Gonadotropin of 600 IU/d does not improve outcome of IVF cycles compared with 450 IU/d in women at risk of poor ovarian response.

CLINICAL TRIAL REGISTRATION NUMBER

NCT00971152.

Authors+Show Affiliations

OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada. Electronic address: jessicalefebvre843@hotmail.com.OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada.OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada.OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26361207

Citation

Lefebvre, Jessica, et al. "450 IU Versus 600 IU Gonadotropin for Controlled Ovarian Stimulation in Poor Responders: a Randomized Controlled Trial." Fertility and Sterility, vol. 104, no. 6, 2015, pp. 1419-25.
Lefebvre J, Antaki R, Kadoch IJ, et al. 450 IU versus 600 IU gonadotropin for controlled ovarian stimulation in poor responders: a randomized controlled trial. Fertil Steril. 2015;104(6):1419-25.
Lefebvre, J., Antaki, R., Kadoch, I. J., Dean, N. L., Sylvestre, C., Bissonnette, F., Benoit, J., Ménard, S., & Lapensée, L. (2015). 450 IU versus 600 IU gonadotropin for controlled ovarian stimulation in poor responders: a randomized controlled trial. Fertility and Sterility, 104(6), 1419-25. https://doi.org/10.1016/j.fertnstert.2015.08.014
Lefebvre J, et al. 450 IU Versus 600 IU Gonadotropin for Controlled Ovarian Stimulation in Poor Responders: a Randomized Controlled Trial. Fertil Steril. 2015;104(6):1419-25. PubMed PMID: 26361207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 450 IU versus 600 IU gonadotropin for controlled ovarian stimulation in poor responders: a randomized controlled trial. AU - Lefebvre,Jessica, AU - Antaki,Roland, AU - Kadoch,Isaac-Jacques, AU - Dean,Nicola L, AU - Sylvestre,Camille, AU - Bissonnette,François, AU - Benoit,Joanne, AU - Ménard,Sylvain, AU - Lapensée,Louise, Y1 - 2015/09/08/ PY - 2015/05/12/received PY - 2015/07/15/revised PY - 2015/08/10/accepted PY - 2015/9/12/entrez PY - 2015/9/12/pubmed PY - 2016/3/26/medline KW - In vitro fertilization KW - controlled ovarian hyperstimulation KW - flare-up protocol KW - gonadotropin dose KW - poor ovarian responder SP - 1419 EP - 25 JF - Fertility and sterility JO - Fertil. Steril. VL - 104 IS - 6 N2 - OBJECTIVE: To compare the outcomes of controlled ovarian stimulation/in vitro fertilization cycles using 450 IU and 600 IU gonadotropin per day in women at risk of poor ovarian response. DESIGN: Prospective randomized controlled nonblinded study. SETTING: University-affiliated private IVF center. PATIENT(S): Women considered to be at risk of poor ovarian response: aged <41 years with basal FSH >10 IU/L, antimüllerian hormone <1 ng/mL, antral follicle count ≤ 8, or a previous IVF cycle with ≥ 300 IU/d gonadotropin that resulted in a cancellation, <8 follicles, or <5 oocytes. INTERVENTION(S): A total of 356 patients underwent a microdose GnRH agonist flare-up IVF/intracytoplasmic sperm injection protocol with a fixed daily dose of either 450 IU FSH (n = 176) or 600 IU FSH (n = 180) equally divided between Menopur and Bravelle. MAIN OUTCOME MEASURE(S): Number of mature oocytes retrieved. RESULT(S): The two groups were similar in terms of age, ovarian reserve, cause of infertility, duration of stimulation, and cycle cancellation rate. There were no significant differences in the number of metaphase II oocytes retrieved (4 [range 0-6] vs. 4 [range 2-7]), fertilization rate (62.4% vs. 57.0%), biochemical pregnancy rate (20.5% vs. 22.9%), clinical pregnancy rate (16.4% vs. 18.3%), and implantation rate (29.8% vs. 30.4%) between the 450 IU and 600 IU groups, respectively. CONCLUSION(S): Gonadotropin of 600 IU/d does not improve outcome of IVF cycles compared with 450 IU/d in women at risk of poor ovarian response. CLINICAL TRIAL REGISTRATION NUMBER: NCT00971152. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/26361207/450_IU_versus_600_IU_gonadotropin_for_controlled_ovarian_stimulation_in_poor_responders:_a_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(15)01851-8 DB - PRIME DP - Unbound Medicine ER -