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The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials.
J Cosmet Dermatol. 2015 Dec; 14(4):291-301.JC

Abstract

BACKGROUND

Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Nutrition is a key factor influencing skin health and consequently its appearance. A wide range of dietary supplements is offered to improve skin health. Collagen peptides are used as a bioactive ingredient in nutricosmetic products and have been shown in preclinical studies to improve skin barrier function, to induce the synthesis of collagen and hyaluronic acid, and to promote fibroblast growth and migration. Our aim was to investigate the effect of oral supplementation with specific collagen peptides on skin hydration and the dermal collagen network in a clinical setting.

METHODS

Two placebo-controlled clinical trials were run to assess the effect of a daily oral supplementation with collagen peptides on skin hydration by corneometry, on collagen density by high-resolution ultrasound and on collagen fragmentation by reflectance confocal microscopy. Human skin explants were used to study extracellular matrix components in the presence of collagen peptides ex vivo.

RESULTS

Oral collagen peptide supplementation significantly increased skin hydration after 8 weeks of intake. The collagen density in the dermis significantly increased and the fragmentation of the dermal collagen network significantly decreased already after 4 weeks of supplementation. Both effects persisted after 12 weeks. Ex vivo experiments demonstrated that collagen peptides induce collagen as well as glycosaminoglycan production, offering a mechanistic explanation for the observed clinical effects.

CONCLUSION

The oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging.

Authors+Show Affiliations

COSderma Laboratory, Bordeaux, France.BIO-EC Laboratory, Longjumeau, France.Unitec Foods, Tokyo, Japan.Rousselot BVBA, Gent, Belgium.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26362110

Citation

Asserin, Jérome, et al. "The Effect of Oral Collagen Peptide Supplementation On Skin Moisture and the Dermal Collagen Network: Evidence From an Ex Vivo Model and Randomized, Placebo-controlled Clinical Trials." Journal of Cosmetic Dermatology, vol. 14, no. 4, 2015, pp. 291-301.
Asserin J, Lati E, Shioya T, et al. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015;14(4):291-301.
Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015). The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14(4), 291-301. https://doi.org/10.1111/jocd.12174
Asserin J, et al. The Effect of Oral Collagen Peptide Supplementation On Skin Moisture and the Dermal Collagen Network: Evidence From an Ex Vivo Model and Randomized, Placebo-controlled Clinical Trials. J Cosmet Dermatol. 2015;14(4):291-301. PubMed PMID: 26362110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. AU - Asserin,Jérome, AU - Lati,Elian, AU - Shioya,Toshiaki, AU - Prawitt,Janne, Y1 - 2015/09/12/ PY - 2015/07/23/accepted PY - 2015/9/13/entrez PY - 2015/9/13/pubmed PY - 2016/10/19/medline KW - anti-aging KW - collagen peptides KW - fragmentation KW - glycosaminoglycan KW - hyaluronic acid KW - reflectance confocal microscopy SP - 291 EP - 301 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 14 IS - 4 N2 - BACKGROUND: Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Nutrition is a key factor influencing skin health and consequently its appearance. A wide range of dietary supplements is offered to improve skin health. Collagen peptides are used as a bioactive ingredient in nutricosmetic products and have been shown in preclinical studies to improve skin barrier function, to induce the synthesis of collagen and hyaluronic acid, and to promote fibroblast growth and migration. Our aim was to investigate the effect of oral supplementation with specific collagen peptides on skin hydration and the dermal collagen network in a clinical setting. METHODS: Two placebo-controlled clinical trials were run to assess the effect of a daily oral supplementation with collagen peptides on skin hydration by corneometry, on collagen density by high-resolution ultrasound and on collagen fragmentation by reflectance confocal microscopy. Human skin explants were used to study extracellular matrix components in the presence of collagen peptides ex vivo. RESULTS: Oral collagen peptide supplementation significantly increased skin hydration after 8 weeks of intake. The collagen density in the dermis significantly increased and the fragmentation of the dermal collagen network significantly decreased already after 4 weeks of supplementation. Both effects persisted after 12 weeks. Ex vivo experiments demonstrated that collagen peptides induce collagen as well as glycosaminoglycan production, offering a mechanistic explanation for the observed clinical effects. CONCLUSION: The oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/26362110/The_effect_of_oral_collagen_peptide_supplementation_on_skin_moisture_and_the_dermal_collagen_network:_evidence_from_an_ex_vivo_model_and_randomized_placebo_controlled_clinical_trials_ L2 - https://doi.org/10.1111/jocd.12174 DB - PRIME DP - Unbound Medicine ER -