TY - JOUR T1 - Compaction behavior and deformation mechanism of directly compressible textured mannitol in a rotary tablet press simulator. AU - Tarlier,Nicolas, AU - Soulairol,Ian, AU - Bataille,Bernard, AU - Baylac,Gilles, AU - Ravel,Patrice, AU - Nofrerias,Isaac, AU - Lefèvre,Philippe, AU - Sharkawi,Tahmer, Y1 - 2015/09/09/ PY - 2015/04/29/received PY - 2015/09/02/revised PY - 2015/09/08/accepted PY - 2015/9/13/entrez PY - 2015/9/13/pubmed PY - 2016/7/28/medline KW - Fragmentary KW - Mean yield pressure KW - Press simulator KW - Textured mannitol KW - lubrication SP - 410 EP - 419 JF - International journal of pharmaceutics JO - Int J Pharm VL - 495 IS - 1 N2 - Textured mannitol powder is widely used as a pharmaceutical excipient for tablet compaction. In order to choose the right tableting parameters, it is necessary to understand its mechanical behavior during deformation under industrial tableting conditions. The aim of this study was to evaluate the mechanical behavior during deformation of a textured mannitol using a rotary tablet press simulator. Mean yield pressure (Py) obtained by Heckel modeling, Walker coefficients (W) and Stress Rate Sensitivity (SRS) were compared to reference excipients, known for either their plastic (microcrystalline cellulose) or fragmentary (lactose and dibasic calcium phosphate) deformation behavior. Py, W and SRS values showed that the studied textured mannitol has a fragmentary deformation mechanism. Furthermore, this mechanical behavior was not sensitive to lubrication, which is characteristic of fragmentary excipients. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/26363108/Compaction_behavior_and_deformation_mechanism_of_directly_compressible_textured_mannitol_in_a_rotary_tablet_press_simulator_ DB - PRIME DP - Unbound Medicine ER -