Tags

Type your tag names separated by a space and hit enter

Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia.
Eur J Nutr 2016; 55(7):2265-74EJ

Abstract

BACKGROUND

Docosahexaenoic (C22:6) and arachidonic acid (C20:4) are long-chain polyunsaturated fatty acids (LC-PUFA), essential to fetal development, and preferentially transported by plasma phospholipids.

OBJECTIVE

To characterize fetal and maternal plasma phospholipid changes during gestation, and to investigate whether LC-PUFA phospholipid profiles are associated with bronchopulmonary dysplasia (BPD).

DESIGN

Cord plasma and parturient serum from N = 108 pregnancies [24-42 week postmenstrual age (PMA)] were collected. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were analyzed with tandem mass spectrometry. PMA-associated changes were quantified, and break point analyses served to describe nonlinear changes during gestation.

RESULTS

PC and PE were lower in cord than in parturient samples. In parturients, PC decreased until 33 week PMA, but then re-increased, whereas in cord plasma, concentrations linearly decreased. Fetal PC and PC sub-group values correlated with maternal values. C20:4-PC was twofold higher in cord than in maternal samples throughout gestation. C22:6-PC values, however, exceeded maternal values only beyond 33 week PMA. Consequently, early preterm C20:4-PC-to-C22:6-PC ratio largely exceeded term infant values. In infants born before 28 week PMA, a low C20:4-PC-to-C22:6-PC ratio was associated with BPD severity.

CONCLUSIONS

Fetal plasma LC-PUFA-PC composition correlates with maternal values. Fetal C20:4-PC exceeds maternal values throughout gestation, whereas C22:6-PC exceeds maternal values only beyond 33 week PMA, resulting in a low fetal C20:4-PC/C22:6-PC ratio only toward end gestation. A low C20:4-PC/C22:6-PC ratio before 28 week PMA is associated with BPD severity. These data point to a concept of PMA-adjusted ARA and DHA supplementation and, potentially, cord plasma phospholipid analysis for BPD prediction.

Authors+Show Affiliations

Department of Neonatology, Faculty of Medicine, Eberhard-Karls-University, Calwer Straβe 7, 72076, Tübingen, Germany. wolfgang.bernhard@med.uni-tuebingen.de.Department of Neonatology, Faculty of Medicine, Eberhard-Karls-University, Calwer Straβe 7, 72076, Tübingen, Germany.Department of Neonatology, Faculty of Medicine, Eberhard-Karls-University, Calwer Straβe 7, 72076, Tübingen, Germany.Department of Neonatology, Faculty of Medicine, Eberhard-Karls-University, Calwer Straβe 7, 72076, Tübingen, Germany.Department of Gynecology, Faculty of Medicine, Eberhard-Karls-University, Tübingen, Germany.Department of Neonatology, Faculty of Medicine, Eberhard-Karls-University, Calwer Straβe 7, 72076, Tübingen, Germany.Department of Neonatology, Faculty of Medicine, Eberhard-Karls-University, Calwer Straβe 7, 72076, Tübingen, Germany. Center for Pediatric Clinical Studies, Faculty of Medicine, Eberhard-Karls-University, Tübingen, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26363610

Citation

Bernhard, Wolfgang, et al. "Developmental Changes in Polyunsaturated Fetal Plasma Phospholipids and Feto-maternal Plasma Phospholipid Ratios and Their Association With Bronchopulmonary Dysplasia." European Journal of Nutrition, vol. 55, no. 7, 2016, pp. 2265-74.
Bernhard W, Raith M, Koch V, et al. Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia. Eur J Nutr. 2016;55(7):2265-74.
Bernhard, W., Raith, M., Koch, V., Maas, C., Abele, H., Poets, C. F., & Franz, A. R. (2016). Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia. European Journal of Nutrition, 55(7), pp. 2265-74. doi:10.1007/s00394-015-1036-5.
Bernhard W, et al. Developmental Changes in Polyunsaturated Fetal Plasma Phospholipids and Feto-maternal Plasma Phospholipid Ratios and Their Association With Bronchopulmonary Dysplasia. Eur J Nutr. 2016;55(7):2265-74. PubMed PMID: 26363610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia. AU - Bernhard,Wolfgang, AU - Raith,Marco, AU - Koch,Vera, AU - Maas,Christoph, AU - Abele,Harald, AU - Poets,Christian F, AU - Franz,Axel R, Y1 - 2015/09/12/ PY - 2015/03/31/received PY - 2015/09/05/accepted PY - 2015/9/14/entrez PY - 2015/9/14/pubmed PY - 2017/4/11/medline KW - Arachidonic acid KW - Docosahexaenoic acid KW - Fetal development KW - LC-PUFA KW - Linoleic acid KW - Phosphatidylcholine KW - Phosphatidylethanolamine KW - Plasma phospholipids KW - Tandem mass spectrometry SP - 2265 EP - 74 JF - European journal of nutrition JO - Eur J Nutr VL - 55 IS - 7 N2 - BACKGROUND: Docosahexaenoic (C22:6) and arachidonic acid (C20:4) are long-chain polyunsaturated fatty acids (LC-PUFA), essential to fetal development, and preferentially transported by plasma phospholipids. OBJECTIVE: To characterize fetal and maternal plasma phospholipid changes during gestation, and to investigate whether LC-PUFA phospholipid profiles are associated with bronchopulmonary dysplasia (BPD). DESIGN: Cord plasma and parturient serum from N = 108 pregnancies [24-42 week postmenstrual age (PMA)] were collected. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were analyzed with tandem mass spectrometry. PMA-associated changes were quantified, and break point analyses served to describe nonlinear changes during gestation. RESULTS: PC and PE were lower in cord than in parturient samples. In parturients, PC decreased until 33 week PMA, but then re-increased, whereas in cord plasma, concentrations linearly decreased. Fetal PC and PC sub-group values correlated with maternal values. C20:4-PC was twofold higher in cord than in maternal samples throughout gestation. C22:6-PC values, however, exceeded maternal values only beyond 33 week PMA. Consequently, early preterm C20:4-PC-to-C22:6-PC ratio largely exceeded term infant values. In infants born before 28 week PMA, a low C20:4-PC-to-C22:6-PC ratio was associated with BPD severity. CONCLUSIONS: Fetal plasma LC-PUFA-PC composition correlates with maternal values. Fetal C20:4-PC exceeds maternal values throughout gestation, whereas C22:6-PC exceeds maternal values only beyond 33 week PMA, resulting in a low fetal C20:4-PC/C22:6-PC ratio only toward end gestation. A low C20:4-PC/C22:6-PC ratio before 28 week PMA is associated with BPD severity. These data point to a concept of PMA-adjusted ARA and DHA supplementation and, potentially, cord plasma phospholipid analysis for BPD prediction. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/26363610/Developmental_changes_in_polyunsaturated_fetal_plasma_phospholipids_and_feto_maternal_plasma_phospholipid_ratios_and_their_association_with_bronchopulmonary_dysplasia_ L2 - https://dx.doi.org/10.1007/s00394-015-1036-5 DB - PRIME DP - Unbound Medicine ER -