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Comparing the Antibacterial and Functional Properties of Cameroonian and Manuka Honeys for Potential Wound Healing-Have We Come Full Cycle in Dealing with Antibiotic Resistance?

Abstract

The increased incidence of bacterial resistance to antibiotics has generated renewed interest in "traditional" antimicrobials, such as honey. This paper reports on a study comparing physico-chemical, antioxidant and antibacterial characteristics (that potentially contribute in part, to the functional wound healing activity) of Cameroonian honeys with those of Manuka honey. Agar well diffusion was used to generate zones of inhibition against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus while broth dilutions were used to study the minimum inhibitory concentrations (MICs). Non-peroxide activity was investigated by catalase for hydrogen peroxide reduction. The Cameroonian honeys demonstrated functional properties similar to Manuka honey, with strong correlations between the antioxidant activity and total phenol content of each honey. They were also as effective as Manuka honey in reducing bacteria load with an MIC of 10% w/v against all three bacteria and exhibited non-peroxide antimicrobial activity. These Cameroon honeys have potential therapeutic activity and may contain compounds with activity against Gram positive and Gram negative bacteria. Antibacterial agents from such natural sources present a potential affordable treatment of wound infections caused by antibiotic resistant bacteria, which are a leading cause of amputations and deaths in many African countries.

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  • Authors+Show Affiliations

    ,

    Department of Pharmaceutical, Chemical & Environmental Sciences, Faculty of Engineering and Science, University of Greenwich, Medway, Central Ave. Chatham Maritime, Kent ME4 4TB, UK. j.s.boateng@gre.ac.uk.

    Department of Pharmaceutical, Chemical & Environmental Sciences, Faculty of Engineering and Science, University of Greenwich, Medway, Central Ave. Chatham Maritime, Kent ME4 4TB, UK. duinase@yahoo.com.

    Source

    Molecules (Basel, Switzerland) 20:9 2015 pg 16068-84

    MeSH

    Anti-Bacterial Agents
    Drug Resistance, Microbial
    Escherichia coli
    Honey
    Microbial Sensitivity Tests
    Pseudomonas aeruginosa
    Staphylococcus aureus
    Wound Healing

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26364634

    Citation

    TY - JOUR T1 - Comparing the Antibacterial and Functional Properties of Cameroonian and Manuka Honeys for Potential Wound Healing-Have We Come Full Cycle in Dealing with Antibiotic Resistance? AU - Boateng,Joshua, AU - Diunase,Keshu Nso, Y1 - 2015/09/02/ PY - 2015/7/02/received PY - 2015/8/28/revised PY - 2015/8/31/accepted PY - 2015/9/15/entrez PY - 2015/9/15/pubmed PY - 2016/6/10/medline KW - Cameroonian honey KW - Manuka honey KW - anti-oxidation activity KW - antibacterial activity KW - antibacterial natural products KW - antibiotic resistance KW - infection KW - minimum inhibitory concentration KW - wound healing SP - 16068 EP - 84 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 20 IS - 9 N2 - The increased incidence of bacterial resistance to antibiotics has generated renewed interest in "traditional" antimicrobials, such as honey. This paper reports on a study comparing physico-chemical, antioxidant and antibacterial characteristics (that potentially contribute in part, to the functional wound healing activity) of Cameroonian honeys with those of Manuka honey. Agar well diffusion was used to generate zones of inhibition against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus while broth dilutions were used to study the minimum inhibitory concentrations (MICs). Non-peroxide activity was investigated by catalase for hydrogen peroxide reduction. The Cameroonian honeys demonstrated functional properties similar to Manuka honey, with strong correlations between the antioxidant activity and total phenol content of each honey. They were also as effective as Manuka honey in reducing bacteria load with an MIC of 10% w/v against all three bacteria and exhibited non-peroxide antimicrobial activity. These Cameroon honeys have potential therapeutic activity and may contain compounds with activity against Gram positive and Gram negative bacteria. Antibacterial agents from such natural sources present a potential affordable treatment of wound infections caused by antibiotic resistant bacteria, which are a leading cause of amputations and deaths in many African countries. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/26364634/Comparing_the_Antibacterial_and_Functional_Properties_of_Cameroonian_and_Manuka_Honeys_for_Potential_Wound_Healing_Have_We_Come_Full_Cycle_in_Dealing_with_Antibiotic_Resistance L2 - http://www.mdpi.com/resolver?pii=molecules200916068 ER -