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Adiposity and risk of thyroid cancer: a systematic review and meta-analysis.

Abstract

Thyroid cancer incidence has increased rapidly over time, as has obesity prevalence. A link between the two appears plausible, but the relation of adiposity to thyroid cancer remains incompletely understood. We performed a meta-analysis of adiposity measures and thyroid cancer using studies identified through October 2014. Twenty-one articles yielded data on 12,199 thyroid cancer cases. We found a statistically significant 25% greater risk of thyroid cancer in overweight individuals and a 55% greater thyroid cancer risk in obese individuals as compared with their normal-weight peers. Each 5-unit increase in body mass index (BMI), 5 kg increase in weight, 5 cm increase in waist or hip circumference and 0.1-unit increase in waist-to-hip ratio were associated with 30%, 5%, 5% and 14% greater risks of thyroid cancer, respectively. When evaluated by histologic type, obesity was significantly positively related to papillary, follicular and anaplastic thyroid cancers, whereas it revealed an inverse association with medullary thyroid cancer. Both general and abdominal adiposity are positively associated with thyroid cancer. However, relations with BMI vary importantly by tumour histologic type.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.

    ,

    Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.

    ,

    Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.

    Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.

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    MeSH

    Adiposity
    Age Factors
    Body Mass Index
    Cell Transformation, Neoplastic
    Humans
    Obesity
    Prevalence
    Risk Factors
    Thyroid Neoplasms
    Waist-Hip Ratio

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    26365757

    Citation

    Schmid, D, et al. "Adiposity and Risk of Thyroid Cancer: a Systematic Review and Meta-analysis." Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, vol. 16, no. 12, 2015, pp. 1042-54.
    Schmid D, Ricci C, Behrens G, et al. Adiposity and risk of thyroid cancer: a systematic review and meta-analysis. Obes Rev. 2015;16(12):1042-54.
    Schmid, D., Ricci, C., Behrens, G., & Leitzmann, M. F. (2015). Adiposity and risk of thyroid cancer: a systematic review and meta-analysis. Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 16(12), pp. 1042-54. doi:10.1111/obr.12321.
    Schmid D, et al. Adiposity and Risk of Thyroid Cancer: a Systematic Review and Meta-analysis. Obes Rev. 2015;16(12):1042-54. PubMed PMID: 26365757.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adiposity and risk of thyroid cancer: a systematic review and meta-analysis. AU - Schmid,D, AU - Ricci,C, AU - Behrens,G, AU - Leitzmann,M F, Y1 - 2015/09/14/ PY - 2015/05/28/received PY - 2015/08/11/revised PY - 2015/08/11/accepted PY - 2015/9/15/entrez PY - 2015/9/15/pubmed PY - 2016/9/23/medline KW - Adiposity KW - meta-analysis KW - thyroid cancer SP - 1042 EP - 54 JF - Obesity reviews : an official journal of the International Association for the Study of Obesity JO - Obes Rev VL - 16 IS - 12 N2 - Thyroid cancer incidence has increased rapidly over time, as has obesity prevalence. A link between the two appears plausible, but the relation of adiposity to thyroid cancer remains incompletely understood. We performed a meta-analysis of adiposity measures and thyroid cancer using studies identified through October 2014. Twenty-one articles yielded data on 12,199 thyroid cancer cases. We found a statistically significant 25% greater risk of thyroid cancer in overweight individuals and a 55% greater thyroid cancer risk in obese individuals as compared with their normal-weight peers. Each 5-unit increase in body mass index (BMI), 5 kg increase in weight, 5 cm increase in waist or hip circumference and 0.1-unit increase in waist-to-hip ratio were associated with 30%, 5%, 5% and 14% greater risks of thyroid cancer, respectively. When evaluated by histologic type, obesity was significantly positively related to papillary, follicular and anaplastic thyroid cancers, whereas it revealed an inverse association with medullary thyroid cancer. Both general and abdominal adiposity are positively associated with thyroid cancer. However, relations with BMI vary importantly by tumour histologic type. SN - 1467-789X UR - https://www.unboundmedicine.com/medline/citation/26365757/full_citation L2 - https://doi.org/10.1111/obr.12321 DB - PRIME DP - Unbound Medicine ER -