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Standing your ground to exoribonucleases: Function of Flavivirus long non-coding RNAs.
Virus Res 2016; 212:70-7VR

Abstract

Members of the Flaviviridae (e.g., Dengue virus, West Nile virus, and Hepatitis C virus) contain a positive-sense RNA genome that encodes a large polyprotein. It is now also clear most if not all of these viruses also produce an abundant subgenomic long non-coding RNA. These non-coding RNAs, which are called subgenomic flavivirus RNAs (sfRNAs) or Xrn1-resistant RNAs (xrRNAs), are stable decay intermediates generated from the viral genomic RNA through the stalling of the cellular exoribonuclease Xrn1 at highly structured regions. Several functions of these flavivirus long non-coding RNAs have been revealed in recent years. The generation of these sfRNAs/xrRNAs from viral transcripts results in the repression of Xrn1 and the dysregulation of cellular mRNA stability. The abundant sfRNAs also serve directly as a decoy for important cellular protein regulators of the interferon and RNA interference antiviral pathways. Thus the generation of long non-coding RNAs from flaviviruses, hepaciviruses and pestiviruses likely disrupts aspects of innate immunity and may directly contribute to viral replication, cytopathology and pathogenesis.

Authors+Show Affiliations

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA. Electronic address: jeffrey.wilusz@colostate.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

26368052

Citation

Charley, Phillida A., and Jeffrey Wilusz. "Standing Your Ground to Exoribonucleases: Function of Flavivirus Long Non-coding RNAs." Virus Research, vol. 212, 2016, pp. 70-7.
Charley PA, Wilusz J. Standing your ground to exoribonucleases: Function of Flavivirus long non-coding RNAs. Virus Res. 2016;212:70-7.
Charley, P. A., & Wilusz, J. (2016). Standing your ground to exoribonucleases: Function of Flavivirus long non-coding RNAs. Virus Research, 212, pp. 70-7. doi:10.1016/j.virusres.2015.09.009.
Charley PA, Wilusz J. Standing Your Ground to Exoribonucleases: Function of Flavivirus Long Non-coding RNAs. Virus Res. 2016 Jan 2;212:70-7. PubMed PMID: 26368052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Standing your ground to exoribonucleases: Function of Flavivirus long non-coding RNAs. AU - Charley,Phillida A, AU - Wilusz,Jeffrey, Y1 - 2015/09/11/ PY - 2015/07/23/received PY - 2015/09/04/revised PY - 2015/09/10/accepted PY - 2015/9/15/entrez PY - 2015/9/15/pubmed PY - 2016/9/16/medline KW - Exoribonuclease KW - Flavivirus KW - IRES KW - Long non-coding RNA KW - RNA decay KW - RNA stability KW - Untranslated regions SP - 70 EP - 7 JF - Virus research JO - Virus Res. VL - 212 N2 - Members of the Flaviviridae (e.g., Dengue virus, West Nile virus, and Hepatitis C virus) contain a positive-sense RNA genome that encodes a large polyprotein. It is now also clear most if not all of these viruses also produce an abundant subgenomic long non-coding RNA. These non-coding RNAs, which are called subgenomic flavivirus RNAs (sfRNAs) or Xrn1-resistant RNAs (xrRNAs), are stable decay intermediates generated from the viral genomic RNA through the stalling of the cellular exoribonuclease Xrn1 at highly structured regions. Several functions of these flavivirus long non-coding RNAs have been revealed in recent years. The generation of these sfRNAs/xrRNAs from viral transcripts results in the repression of Xrn1 and the dysregulation of cellular mRNA stability. The abundant sfRNAs also serve directly as a decoy for important cellular protein regulators of the interferon and RNA interference antiviral pathways. Thus the generation of long non-coding RNAs from flaviviruses, hepaciviruses and pestiviruses likely disrupts aspects of innate immunity and may directly contribute to viral replication, cytopathology and pathogenesis. SN - 1872-7492 UR - https://www.unboundmedicine.com/medline/citation/26368052/Standing_your_ground_to_exoribonucleases:_Function_of_Flavivirus_long_non_coding_RNAs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(15)30064-2 DB - PRIME DP - Unbound Medicine ER -