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Second trimester maternal plasma and amniotic fluid adipokines in women who will develop gestational diabetes mellitus.
Gynecol Endocrinol. 2015; 31(12):934-8.GE

Abstract

OBJECTIVE

To study the adipokines concentration and glucose homoeostasis in the early-second trimester of women who will develop gestational diabetes mellitus (GDM).

MATERIALS AND METHODS

Maternal plasma and fetal amniotic fluid samples were prospectively collected between 2006 and 2007 at the time of mid-trimester amniocentesis. Eight patients found to be affected by GDM were compared with 10 control patients with a normal pregnancy course. Adipokines leptin and adiponectin, as well as insulin and glucose concentration both in amniotic fluid and maternal plasma were compared between cases and controls. HOMA-IR (homeostatic model assessment for insulin resistance) was also calculated both for amniotic fluid and maternal serum.

RESULTS

The amniotic fluid adiponectin concentration was higher in women who would develop GDM than in controls (29.9 ng/ml, 95% CI 26.7-49.8 ng/ml, versus 14.9 ng/ml, 95% CI 13.5-18.8 ng/ml), p < 0.05). No difference was shown for leptin both in amniotic fluid and maternal serum. Insulin concentrations in the amniotic fluid were found to be lower in GDM than in controls, while HOMA-IR-index resulted lower in amniotic fluid and higher maternal serum (p < 0.05).

CONCLUSIONS

Our data suggests that an earlier alteration in the fetal glucose metabolism will precede the glucose dysmetabolism in pregnancies later complicated by GDM.

Authors+Show Affiliations

a Clinic of Obstetrics and Gynaecology, St. Franziskus-Hospital, Münster , Germany . b Clinic of Obstetrics and Gynaecology, University of Münster , Germany .c Clinic of Obstetrics and Gynaecology, University of Udine , Italy .d Department of Clinical and Biological Sciences , University of Udine , Italy , and.d Department of Clinical and Biological Sciences , University of Udine , Italy , and.e Clinic of Surgical Semeiotics, University of Udine , Italy.c Clinic of Obstetrics and Gynaecology, University of Udine , Italy .c Clinic of Obstetrics and Gynaecology, University of Udine , Italy .

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26369835

Citation

Fruscalzo, Arrigo, et al. "Second Trimester Maternal Plasma and Amniotic Fluid Adipokines in Women Who Will Develop Gestational Diabetes Mellitus." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 31, no. 12, 2015, pp. 934-8.
Fruscalzo A, Londero AP, Biasizzo J, et al. Second trimester maternal plasma and amniotic fluid adipokines in women who will develop gestational diabetes mellitus. Gynecol Endocrinol. 2015;31(12):934-8.
Fruscalzo, A., Londero, A. P., Biasizzo, J., Curcio, F., Bertozzi, S., Marchesoni, D., & Driul, L. (2015). Second trimester maternal plasma and amniotic fluid adipokines in women who will develop gestational diabetes mellitus. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 31(12), 934-8. https://doi.org/10.3109/09513590.2015.1079611
Fruscalzo A, et al. Second Trimester Maternal Plasma and Amniotic Fluid Adipokines in Women Who Will Develop Gestational Diabetes Mellitus. Gynecol Endocrinol. 2015;31(12):934-8. PubMed PMID: 26369835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Second trimester maternal plasma and amniotic fluid adipokines in women who will develop gestational diabetes mellitus. AU - Fruscalzo,Arrigo, AU - Londero,Ambrogio P, AU - Biasizzo,Jessica, AU - Curcio,Francesco, AU - Bertozzi,Serena, AU - Marchesoni,Diego, AU - Driul,Lorenza, Y1 - 2015/09/15/ PY - 2015/9/16/entrez PY - 2015/9/16/pubmed PY - 2016/9/22/medline KW - Adipokines KW - adiponectin KW - amniotic fluid KW - gestational diabetes mellitus KW - insulin resistance KW - leptin KW - plasma KW - pregnancy SP - 934 EP - 8 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 31 IS - 12 N2 - OBJECTIVE: To study the adipokines concentration and glucose homoeostasis in the early-second trimester of women who will develop gestational diabetes mellitus (GDM). MATERIALS AND METHODS: Maternal plasma and fetal amniotic fluid samples were prospectively collected between 2006 and 2007 at the time of mid-trimester amniocentesis. Eight patients found to be affected by GDM were compared with 10 control patients with a normal pregnancy course. Adipokines leptin and adiponectin, as well as insulin and glucose concentration both in amniotic fluid and maternal plasma were compared between cases and controls. HOMA-IR (homeostatic model assessment for insulin resistance) was also calculated both for amniotic fluid and maternal serum. RESULTS: The amniotic fluid adiponectin concentration was higher in women who would develop GDM than in controls (29.9 ng/ml, 95% CI 26.7-49.8 ng/ml, versus 14.9 ng/ml, 95% CI 13.5-18.8 ng/ml), p < 0.05). No difference was shown for leptin both in amniotic fluid and maternal serum. Insulin concentrations in the amniotic fluid were found to be lower in GDM than in controls, while HOMA-IR-index resulted lower in amniotic fluid and higher maternal serum (p < 0.05). CONCLUSIONS: Our data suggests that an earlier alteration in the fetal glucose metabolism will precede the glucose dysmetabolism in pregnancies later complicated by GDM. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/26369835/Second_trimester_maternal_plasma_and_amniotic_fluid_adipokines_in_women_who_will_develop_gestational_diabetes_mellitus_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2015.1079611 DB - PRIME DP - Unbound Medicine ER -