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Genotype diversity and distribution of Orientia tsutsugamushi in scrub typhus patients and rodents in Shandong, northern China.
Infect Genet Evol. 2015 Dec; 36:126-130.IG

Abstract

Orientia tsutsugamushi, the etiologic agent of scrub typhus, is transmitted to humans through the bites of infected chiggers. To identify the genotypes of O.tsutsugamushi and their geographical distribution in Shandong, 236 patient's samples and 1606 captured rodents were collected in major-endemic regions of Shandong Province from June 2013 to December 2014. Sequences were determined for the 56-kDa TSA gene, and the relationship between these sequences and those previously determined was assessed. Two genotypes out of 5 previously reported in Shandong were identified, i.e. Kawasaki-related and STA-07. The Kawasaki-related genotype was predominant (82.1% (23/28) in human and 50% (5/10) in rodents), with wide distribution through the endemic areas of Shandong Province. The STA-07 was confined to Tai'an, Linyi and Qingdao districts. The Fuji-related, Shimikoshi-related and Karp-related genotypes were not found, while identified in previous studies. For prevention and control of scrub typhus in Shandong, more attention should be paid to surveillance of Kawasaki-related and STA-07 genotypes.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zheng L
Department of Epidemiology, School of Public Health, Shandong University, 44 Wenhuaxi Road, Jinan 250012, China.
Bi Z
Institute for Bacterial Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan 250012, China.
Kou Z
Institute for Bacterial Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan 250012, China.
Yang H
Department of Epidemiology, School of Public Health, Shandong University, 44 Wenhuaxi Road, Jinan 250012, China.
Zhang L
Department of Epidemiology, School of Public Health, Shandong University, 44 Wenhuaxi Road, Jinan 250012, China.
Zhao Z
Department of Epidemiology, School of Public Health, Shandong University, 44 Wenhuaxi Road, Jinan 250012, China. Electronic address: ztzhao@sdu.edu.cn.

MeSH

Animal DiseasesAnimalsAntigens, BacterialChinaGenes, BacterialGenetic VariationGenotypeHumansOrientia tsutsugamushiPhylogenyPhylogeographyRodentiaScrub TyphusSeasons

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26371067

Citation

Zheng, Li, et al. "Genotype Diversity and Distribution of Orientia Tsutsugamushi in Scrub Typhus Patients and Rodents in Shandong, Northern China." Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, vol. 36, 2015, pp. 126-130.
Zheng L, Bi Z, Kou Z, et al. Genotype diversity and distribution of Orientia tsutsugamushi in scrub typhus patients and rodents in Shandong, northern China. Infect Genet Evol. 2015;36:126-130.
Zheng, L., Bi, Z., Kou, Z., Yang, H., Zhang, L., & Zhao, Z. (2015). Genotype diversity and distribution of Orientia tsutsugamushi in scrub typhus patients and rodents in Shandong, northern China. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 36, 126-130. https://doi.org/10.1016/j.meegid.2015.09.008
Zheng L, et al. Genotype Diversity and Distribution of Orientia Tsutsugamushi in Scrub Typhus Patients and Rodents in Shandong, Northern China. Infect Genet Evol. 2015;36:126-130. PubMed PMID: 26371067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genotype diversity and distribution of Orientia tsutsugamushi in scrub typhus patients and rodents in Shandong, northern China. AU - Zheng,Li, AU - Bi,Zhenwang, AU - Kou,Zengqiang, AU - Yang,Hui, AU - Zhang,Luyan, AU - Zhao,Zhongtang, Y1 - 2015/09/12/ PY - 2015/06/05/received PY - 2015/08/13/revised PY - 2015/09/10/accepted PY - 2015/9/16/entrez PY - 2015/9/16/pubmed PY - 2016/8/20/medline KW - 56-kDa type specific antigen gene KW - Geographic distribution KW - Orientia tsutsugamushi KW - Phylogenetic analysis KW - Scrub typhus SP - 126 EP - 130 JF - Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases JO - Infect Genet Evol VL - 36 N2 - Orientia tsutsugamushi, the etiologic agent of scrub typhus, is transmitted to humans through the bites of infected chiggers. To identify the genotypes of O.tsutsugamushi and their geographical distribution in Shandong, 236 patient's samples and 1606 captured rodents were collected in major-endemic regions of Shandong Province from June 2013 to December 2014. Sequences were determined for the 56-kDa TSA gene, and the relationship between these sequences and those previously determined was assessed. Two genotypes out of 5 previously reported in Shandong were identified, i.e. Kawasaki-related and STA-07. The Kawasaki-related genotype was predominant (82.1% (23/28) in human and 50% (5/10) in rodents), with wide distribution through the endemic areas of Shandong Province. The STA-07 was confined to Tai'an, Linyi and Qingdao districts. The Fuji-related, Shimikoshi-related and Karp-related genotypes were not found, while identified in previous studies. For prevention and control of scrub typhus in Shandong, more attention should be paid to surveillance of Kawasaki-related and STA-07 genotypes. SN - 1567-7257 UR - https://www.unboundmedicine.com/medline/citation/26371067/Genotype_diversity_and_distribution_of_Orientia_tsutsugamushi_in_scrub_typhus_patients_and_rodents_in_Shandong_northern_China_ DB - PRIME DP - Unbound Medicine ER -