Tags

Type your tag names separated by a space and hit enter

TRPs and pain.
Semin Immunopathol. 2016 05; 38(3):277-91.SI

Abstract

Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cerebral cortex, where pain is finally sensed. Transient receptor potential (TRP) ion channels have emerged as a family of evolutionarily conserved ligand-gated ion channels that function as molecular detectors of physical stimuli. Several member of this family, at least six channels from three TRP family subtypes (TRPV1-4, TRPM8, and TRPA1), are expressed in nociceptors, where they act as transducers for signals from thermal, chemical, and mechanical stimuli and play crucial roles in the generation and development of pathological pain perception. This review focuses on the increasing evidence of TRP channel involvement and contribution in nociceptive pain and the pain hypersensitivity associated with peripheral inflammation or neuropathy, and on the renewed interest in targeting TRP channels for pain relief.

Authors+Show Affiliations

Department of Pharmacotherapy and Oriental Medicine, School of Pharmacy, Hyogo University of Health Sciences, 1-3-6 Minatojima, Chuo-ku, Kobe, Hyogo, 650-8530, Japan. ydai@huhs.ac.jp. Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan. ydai@huhs.ac.jp. Traditional Medicine Research Center, Chinese Medicine Confucius Institute at Hyogo College of Medicine, Kobe, Hyogo, 650-8530, Japan. ydai@huhs.ac.jp.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26374740

Citation

Dai, Yi. "TRPs and Pain." Seminars in Immunopathology, vol. 38, no. 3, 2016, pp. 277-91.
Dai Y. TRPs and pain. Semin Immunopathol. 2016;38(3):277-91.
Dai, Y. (2016). TRPs and pain. Seminars in Immunopathology, 38(3), 277-91. https://doi.org/10.1007/s00281-015-0526-0
Dai Y. TRPs and Pain. Semin Immunopathol. 2016;38(3):277-91. PubMed PMID: 26374740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRPs and pain. A1 - Dai,Yi, Y1 - 2015/09/15/ PY - 2015/09/01/received PY - 2015/09/03/accepted PY - 2015/9/17/entrez PY - 2015/9/17/pubmed PY - 2017/11/4/medline KW - Neuropathy KW - Nociception KW - Pain KW - Peripheral inflammation KW - TRP channel SP - 277 EP - 91 JF - Seminars in immunopathology JO - Semin Immunopathol VL - 38 IS - 3 N2 - Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cerebral cortex, where pain is finally sensed. Transient receptor potential (TRP) ion channels have emerged as a family of evolutionarily conserved ligand-gated ion channels that function as molecular detectors of physical stimuli. Several member of this family, at least six channels from three TRP family subtypes (TRPV1-4, TRPM8, and TRPA1), are expressed in nociceptors, where they act as transducers for signals from thermal, chemical, and mechanical stimuli and play crucial roles in the generation and development of pathological pain perception. This review focuses on the increasing evidence of TRP channel involvement and contribution in nociceptive pain and the pain hypersensitivity associated with peripheral inflammation or neuropathy, and on the renewed interest in targeting TRP channels for pain relief. SN - 1863-2300 UR - https://www.unboundmedicine.com/medline/citation/26374740/TRPs_and_pain_ L2 - https://dx.doi.org/10.1007/s00281-015-0526-0 DB - PRIME DP - Unbound Medicine ER -