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Syndrome of rapid onset ESRD accounted for high hemodialysis catheter use--results of a 13-year Mayo Clinic incident hemodialysis study.
Ren Fail. 2015; 37(9):1486-91.RF

Abstract

BACKGROUND

The syndrome of rapid onset end-stage renal disease (SORO-ESRD) was first described in the journal Renal Failure in 2010. This is an acute precipitate unpredictable yet irreversible ESRD following acute kidney injury (AKI), as distinct from "classic" ESRD where chronic kidney disease (CKD)-ESRD progression was linear, time-dependent, and predictable. The overall impact of SORO-ESRD on ESRD outcomes in the adult US ESRD population remains speculative and called for larger studies.

METHODS

A retrospective investigation of an incident adult ESRD population, Mayo Clinic, Rochester, 2001-2013.

RESULTS

One hundred and forty-nine of 1461 (10%) incident patients with ESRD had SORO-ESRD - M:F = 76:73, age 62 (19-95) years, 139 (93%) native kidneys, and 10 (7%) renal transplant recipients (RTRs). The modal age group was 71-80 years. A total of 147 (99%) SORO-ESRD patients started first hemodialysis treatment via a dialysis catheter. Kidney biopsy in 10 RTRs and 34 native kidneys revealed acute tubular necrosis (ATN) as the commonest pathology. Cardiac arrest remained the leading cause of death among SORO-ESRD patients.

CONCLUSIONS

SORO-ESRD accounted for 149 (10%) of 1461 incident ESRD patients. There was no gender disparity. The older population was more susceptible. Ninety-nine percent (99%) of SORO-ESRD patients started their first hemodialysis treatment via a dialysis catheter, a major negative impact on AV fistula first programs. ATN was the leading pathologic diagnosis. We conclude that SORO-ESRD contributes significantly to incident ESRD here in the USA including renal allograft loss. Efforts to reduce AKI incidence or renoprevention demand more attention and priority.

Authors+Show Affiliations

a Mayo Clinic College of Medicine , Rochester , MN , USA . b Department of Nephrology , Mayo Clinic Health System , Eau Claire , WI , USA . c MBA Executive, Mayo Clinic Health System, Eau Claire , WI , USA , and.d Psychiatry Nursing, North East London NHS Foundation Trust , UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26375630

Citation

Onuigbo, Macaulay, and Nneoma Agbasi. "Syndrome of Rapid Onset ESRD Accounted for High Hemodialysis Catheter Use--results of a 13-year Mayo Clinic Incident Hemodialysis Study." Renal Failure, vol. 37, no. 9, 2015, pp. 1486-91.
Onuigbo M, Agbasi N. Syndrome of rapid onset ESRD accounted for high hemodialysis catheter use--results of a 13-year Mayo Clinic incident hemodialysis study. Ren Fail. 2015;37(9):1486-91.
Onuigbo, M., & Agbasi, N. (2015). Syndrome of rapid onset ESRD accounted for high hemodialysis catheter use--results of a 13-year Mayo Clinic incident hemodialysis study. Renal Failure, 37(9), 1486-91. https://doi.org/10.3109/0886022X.2015.1088336
Onuigbo M, Agbasi N. Syndrome of Rapid Onset ESRD Accounted for High Hemodialysis Catheter Use--results of a 13-year Mayo Clinic Incident Hemodialysis Study. Ren Fail. 2015;37(9):1486-91. PubMed PMID: 26375630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Syndrome of rapid onset ESRD accounted for high hemodialysis catheter use--results of a 13-year Mayo Clinic incident hemodialysis study. AU - Onuigbo,Macaulay, AU - Agbasi,Nneoma, Y1 - 2015/09/16/ PY - 2015/9/17/entrez PY - 2015/9/17/pubmed PY - 2016/8/2/medline KW - Acute kidney injury KW - chronic kidney disease KW - end-stage renal disease KW - hemodialysis KW - renal replacement therapy KW - syndrome of rapid onset end-stage renal disease SP - 1486 EP - 91 JF - Renal failure JO - Ren Fail VL - 37 IS - 9 N2 - BACKGROUND: The syndrome of rapid onset end-stage renal disease (SORO-ESRD) was first described in the journal Renal Failure in 2010. This is an acute precipitate unpredictable yet irreversible ESRD following acute kidney injury (AKI), as distinct from "classic" ESRD where chronic kidney disease (CKD)-ESRD progression was linear, time-dependent, and predictable. The overall impact of SORO-ESRD on ESRD outcomes in the adult US ESRD population remains speculative and called for larger studies. METHODS: A retrospective investigation of an incident adult ESRD population, Mayo Clinic, Rochester, 2001-2013. RESULTS: One hundred and forty-nine of 1461 (10%) incident patients with ESRD had SORO-ESRD - M:F = 76:73, age 62 (19-95) years, 139 (93%) native kidneys, and 10 (7%) renal transplant recipients (RTRs). The modal age group was 71-80 years. A total of 147 (99%) SORO-ESRD patients started first hemodialysis treatment via a dialysis catheter. Kidney biopsy in 10 RTRs and 34 native kidneys revealed acute tubular necrosis (ATN) as the commonest pathology. Cardiac arrest remained the leading cause of death among SORO-ESRD patients. CONCLUSIONS: SORO-ESRD accounted for 149 (10%) of 1461 incident ESRD patients. There was no gender disparity. The older population was more susceptible. Ninety-nine percent (99%) of SORO-ESRD patients started their first hemodialysis treatment via a dialysis catheter, a major negative impact on AV fistula first programs. ATN was the leading pathologic diagnosis. We conclude that SORO-ESRD contributes significantly to incident ESRD here in the USA including renal allograft loss. Efforts to reduce AKI incidence or renoprevention demand more attention and priority. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/26375630/Syndrome_of_rapid_onset_ESRD_accounted_for_high_hemodialysis_catheter_use__results_of_a_13_year_Mayo_Clinic_incident_hemodialysis_study_ DB - PRIME DP - Unbound Medicine ER -