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Associations between body mass index and maternal weight gain on the delivery of LGA infants in Chinese women with gestational diabetes mellitus.
J Diabetes Complications 2015 Nov-Dec; 29(8):1037-41JD

Abstract

BACKGROUND

Women with gestational diabetes mellitus (GDM) are at increased risk for maternal and fetal complications including delivery of large for gestational age (LGA) infants. Maternal body mass index (BMI) and excessive weight gain during pregnancy are associated with delivery of LGA infants. However, whether maternal BMI and weight gain are associated with LGA infants in women with GDM is unclear.

BASIC PROCEDURES

Data on 1049 pregnant women who developed GDM were collected from a university teaching hospital in China and retrospectively analyzed. Data included maternal BMI, weight gain, incidence of LGA and gestational week at diagnosis.

MAIN FINDINGS

The incidence of LGA infants was significantly associated with maternal BMI (p=0.0002) in women with GDM. The odds of delivery of LGA for obese or overweight pregnant women are 3.8 or 2 times more than normal weight pregnant women. The incidence of LGA infants was also significantly associated with maternal weight gain in women with GDM. The odds ratio of delivery of LGA for pregnant women with excessive weight gain was 3.3 times more than pregnant women with normal weight gain. The effect of weight gain was not significantly different between different maternal BMI.

PRINCIPAL CONCLUSION

The incidence of delivery of LGA infants in Chinese women with GDM who were overweight or obese is higher than Caucasians, Hispanic, and Asian-Americans. The effects of maternal BMI and weight gain on the delivery of LGA infants by women with GDM are additive.

Authors+Show Affiliations

The Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai, China; Department of Obstetrics & Gynaecology, The University of Auckland, Auckland, New Zealand.Department of Obstetrics & Gynaecology, The University of Auckland, Auckland, New Zealand.Department of Obstetrics & Gynaecology, The University of Auckland, Auckland, New Zealand.Department of Anatomy with Radiology, The University of Auckland, Auckland, New Zealand.Section of Epidemiology and Biostatistics, School of Population Health, The University of Auckland, New Zealand.The Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai, China.Wuxi Maternity and Child Health Hospital, Nanjing Medical University, Wuxi, China. Electronic address: q.chen@auckland.ac.nz.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26376766

Citation

Chen, Qi, et al. "Associations Between Body Mass Index and Maternal Weight Gain On the Delivery of LGA Infants in Chinese Women With Gestational Diabetes Mellitus." Journal of Diabetes and Its Complications, vol. 29, no. 8, 2015, pp. 1037-41.
Chen Q, Wei J, Tong M, et al. Associations between body mass index and maternal weight gain on the delivery of LGA infants in Chinese women with gestational diabetes mellitus. J Diabetes Complicat. 2015;29(8):1037-41.
Chen, Q., Wei, J., Tong, M., Yu, L., Lee, A. C., Gao, Y. F., & Zhao, M. (2015). Associations between body mass index and maternal weight gain on the delivery of LGA infants in Chinese women with gestational diabetes mellitus. Journal of Diabetes and Its Complications, 29(8), pp. 1037-41. doi:10.1016/j.jdiacomp.2015.08.017.
Chen Q, et al. Associations Between Body Mass Index and Maternal Weight Gain On the Delivery of LGA Infants in Chinese Women With Gestational Diabetes Mellitus. J Diabetes Complicat. 2015;29(8):1037-41. PubMed PMID: 26376766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between body mass index and maternal weight gain on the delivery of LGA infants in Chinese women with gestational diabetes mellitus. AU - Chen,Qi, AU - Wei,J, AU - Tong,M, AU - Yu,L, AU - Lee,A C, AU - Gao,Y F, AU - Zhao,M, Y1 - 2015/08/22/ PY - 2015/03/17/received PY - 2015/07/31/revised PY - 2015/08/20/accepted PY - 2015/9/18/entrez PY - 2015/9/18/pubmed PY - 2016/9/13/medline KW - Body mass index KW - Excessive weight gain KW - Gestational diabetes mellitus KW - Large for gestational age KW - Maternal obesity SP - 1037 EP - 41 JF - Journal of diabetes and its complications JO - J. Diabetes Complicat. VL - 29 IS - 8 N2 - BACKGROUND: Women with gestational diabetes mellitus (GDM) are at increased risk for maternal and fetal complications including delivery of large for gestational age (LGA) infants. Maternal body mass index (BMI) and excessive weight gain during pregnancy are associated with delivery of LGA infants. However, whether maternal BMI and weight gain are associated with LGA infants in women with GDM is unclear. BASIC PROCEDURES: Data on 1049 pregnant women who developed GDM were collected from a university teaching hospital in China and retrospectively analyzed. Data included maternal BMI, weight gain, incidence of LGA and gestational week at diagnosis. MAIN FINDINGS: The incidence of LGA infants was significantly associated with maternal BMI (p=0.0002) in women with GDM. The odds of delivery of LGA for obese or overweight pregnant women are 3.8 or 2 times more than normal weight pregnant women. The incidence of LGA infants was also significantly associated with maternal weight gain in women with GDM. The odds ratio of delivery of LGA for pregnant women with excessive weight gain was 3.3 times more than pregnant women with normal weight gain. The effect of weight gain was not significantly different between different maternal BMI. PRINCIPAL CONCLUSION: The incidence of delivery of LGA infants in Chinese women with GDM who were overweight or obese is higher than Caucasians, Hispanic, and Asian-Americans. The effects of maternal BMI and weight gain on the delivery of LGA infants by women with GDM are additive. SN - 1873-460X UR - https://www.unboundmedicine.com/medline/citation/26376766/Associations_between_body_mass_index_and_maternal_weight_gain_on_the_delivery_of_LGA_infants_in_Chinese_women_with_gestational_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(15)00363-3 DB - PRIME DP - Unbound Medicine ER -