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New therapeutic approaches for the prevention and treatment of migraine.
Lancet Neurol 2015; 14(10):1010-22LN

Abstract

The management of patients with migraine is often unsatisfactory because available acute and preventive therapies are either ineffective or poorly tolerated. The acute treatment of migraine attacks has been limited to the use of analgesics, combinations of analgesics with caffeine, ergotamines, and the triptans. Successful new approaches for the treatment of acute migraine target calcitonin gene-related peptide (CGRP) and serotonin (5-hydroxytryptamine, 5-HT1F) receptors. Other approaches targeting the transient receptor potential vanilloid (TRPV1) receptor, glutamate, GABAA receptors, or a combination of 5-HT1B/1D receptors and neuronal nitric oxide synthesis have been investigated but have not been successful in clinical trials thus far. In migraine prevention, the most promising new approaches are humanised antibodies against CGRP or the CGRP receptor. Non-invasive and invasive neuromodulation approaches also show promise as both acute and preventive therapies, although further studies are needed to define appropriate candidates for these therapies and optimum protocols for their use.

Authors+Show Affiliations

Department of Neurology and Headache Center, University of Duisburg-Essen, Essen, Germany. Electronic address: hans.diener@uk-essen.de.Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.NIHR-Wellcome Trust King's Clinical Research Facility, King's College London, London, UK.Department of Neurology and Headache Center, University of Duisburg-Essen, Essen, Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26376968

Citation

Diener, Hans-Christoph, et al. "New Therapeutic Approaches for the Prevention and Treatment of Migraine." The Lancet. Neurology, vol. 14, no. 10, 2015, pp. 1010-22.
Diener HC, Charles A, Goadsby PJ, et al. New therapeutic approaches for the prevention and treatment of migraine. Lancet Neurol. 2015;14(10):1010-22.
Diener, H. C., Charles, A., Goadsby, P. J., & Holle, D. (2015). New therapeutic approaches for the prevention and treatment of migraine. The Lancet. Neurology, 14(10), pp. 1010-22. doi:10.1016/S1474-4422(15)00198-2.
Diener HC, et al. New Therapeutic Approaches for the Prevention and Treatment of Migraine. Lancet Neurol. 2015;14(10):1010-22. PubMed PMID: 26376968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New therapeutic approaches for the prevention and treatment of migraine. AU - Diener,Hans-Christoph, AU - Charles,Andrew, AU - Goadsby,Peter J, AU - Holle,Dagny, PY - 2014/11/23/received PY - 2015/07/27/revised PY - 2015/07/29/accepted PY - 2015/9/18/entrez PY - 2015/9/18/pubmed PY - 2015/12/23/medline SP - 1010 EP - 22 JF - The Lancet. Neurology JO - Lancet Neurol VL - 14 IS - 10 N2 - The management of patients with migraine is often unsatisfactory because available acute and preventive therapies are either ineffective or poorly tolerated. The acute treatment of migraine attacks has been limited to the use of analgesics, combinations of analgesics with caffeine, ergotamines, and the triptans. Successful new approaches for the treatment of acute migraine target calcitonin gene-related peptide (CGRP) and serotonin (5-hydroxytryptamine, 5-HT1F) receptors. Other approaches targeting the transient receptor potential vanilloid (TRPV1) receptor, glutamate, GABAA receptors, or a combination of 5-HT1B/1D receptors and neuronal nitric oxide synthesis have been investigated but have not been successful in clinical trials thus far. In migraine prevention, the most promising new approaches are humanised antibodies against CGRP or the CGRP receptor. Non-invasive and invasive neuromodulation approaches also show promise as both acute and preventive therapies, although further studies are needed to define appropriate candidates for these therapies and optimum protocols for their use. SN - 1474-4465 UR - https://www.unboundmedicine.com/medline/citation/26376968/New_therapeutic_approaches_for_the_prevention_and_treatment_of_migraine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1474-4422(15)00198-2 DB - PRIME DP - Unbound Medicine ER -