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Non-invasive determination by cardiovascular magnetic resonance of right ventricular-vascular coupling in children and adolescents with pulmonary hypertension.
J Cardiovasc Magn Reson. 2015 Sep 16; 17:81.JC

Abstract

BACKGROUND

Pediatric pulmonary hypertension (PH) remains a disease with high morbidity and mortality in children. Understanding ventricular-vascular coupling, a measure of how well matched the ventricular and vascular function are, may elucidate pathway leading to right heart failure. Ventricular vascular coupling ratio (VVCR), comprised of effective elastance (Ea, index of arterial load) and right ventricular maximal end-systolic elastance (Ees, index of contractility), is conventionally determined by catheterization. Here, we apply a non-invasive approach to determining VVCR in pediatric subjects with PH.

METHODS

This retrospective study included PH subjects who had a cardiovascular magnetic resonance (CMR) study within 14 days of cardiac catheterization. PH was defined as mean pulmonary artery pressure (mPAP) ≥ 25 mmHg on prior or current catheterization. A non-invasive measure of VVCR was derived from CMR-only (VVCRm) and compared to VVCR estimated by catheterization-derived single beat estimation (VVCRs). Indexed pulmonary vascular resistance (PVRi) and pulmonary vascular reactivity were determined during the catheterization procedure. Pearson correlation coefficients were calculated between PVRi and VVCRm. Receiver operating characteristic (ROC) curve analysis determined the diagnostic value of VVCRm in predicting vascular reactivity.

RESULTS

Seventeen subjects (3 months-23 years; mean 11.3 ± 7.4 years) were identified between January 2009-August 2013 for inclusion with equal gender distributions. Mean mPAP was 35 mmHg ± 15 and PVRi was 8.5 Woods unit x m2 ± 7.8. VVCRm (range 0.43-2.82) increased with increasing severity as defined by PVRi (p < 0.001), and was highly correlated with PVRi (r = 0.92, 95 % CI 0.79-0.97, p < 0.0001). Regression of VVCRm and PVRi demonstrated differing lines when separated by reactivity. VVCRm was significantly correlated with VVCRs (r = 0.79, CI 0.48-0.99, p <0.0001). ROC curve analysis showed high accuracy of VVCRm in determining vascular reactivity (VVCR = 0.85 had a sensitivity of 100 % and a specificity of 80 %) with an area under the curve of 0.89 (p = 0.008).

CONCLUSION

Measurement of VVCRm in pediatrics is feasible. Pulmonary vascular non-reactivity may be contribute to ventricular-vascular decoupling in severe PH. Therapeutic intervention to maintain a low vascular afterload in reactive patients may preserve right ventricular functional reserve and delay the onset of RV-PA decoupling. Use of VVCRm may have significant prognostic implication.

Authors+Show Affiliations

Division of Pediatric Cardiology, Children's Hospital Colorado, Aurora, CO, 80045, USA. uyen.truong@childrenscolorado.org. Department for Pediatrics, Division of Cardiology, Children's Hospital Colorado, University of Colorado Anschultz Medical Center, 13123 E. 16th Avenue, B100, Aurora, CO, 80045, USA. uyen.truong@childrenscolorado.org.Division of Pediatric Cardiology, Children's Hospital Colorado, Aurora, CO, 80045, USA. sonali.patel@childrenscolorado.org.Department of Bioengineering, University of Colorado Denver Medical Campus, Aurora, CO, 80045, USA. vitaly.kheyfets@childrenscolorado.org.Department of Bioengineering, University of Colorado Denver Medical Campus, Aurora, CO, 80045, USA. jdunning07@hotmail.com.Division of Pediatric Cardiology, Children's Hospital Colorado, Aurora, CO, 80045, USA. brian.fonseca@childrenscolorado.org.Department of Radiology, Northwestern University, Chicago, IL, USA. alex.barker@northwestern.edu.Division of Pediatric Cardiology, Children's Hospital Colorado, Aurora, CO, 80045, USA. dunbar.ivy@childrenscolorado.org.Division of Pediatric Cardiology, Children's Hospital Colorado, Aurora, CO, 80045, USA. robin.shandas@ucdenver.edu. Department of Bioengineering, University of Colorado Denver Medical Campus, Aurora, CO, 80045, USA. robin.shandas@ucdenver.edu.Division of Pediatric Cardiology, Children's Hospital Colorado, Aurora, CO, 80045, USA. kendall.hunter@ucdenver.edu. Department of Bioengineering, University of Colorado Denver Medical Campus, Aurora, CO, 80045, USA. kendall.hunter@ucdenver.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26376972

Citation

Truong, Uyen, et al. "Non-invasive Determination By Cardiovascular Magnetic Resonance of Right Ventricular-vascular Coupling in Children and Adolescents With Pulmonary Hypertension." Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance, vol. 17, 2015, p. 81.
Truong U, Patel S, Kheyfets V, et al. Non-invasive determination by cardiovascular magnetic resonance of right ventricular-vascular coupling in children and adolescents with pulmonary hypertension. J Cardiovasc Magn Reson. 2015;17:81.
Truong, U., Patel, S., Kheyfets, V., Dunning, J., Fonseca, B., Barker, A. J., Ivy, D., Shandas, R., & Hunter, K. (2015). Non-invasive determination by cardiovascular magnetic resonance of right ventricular-vascular coupling in children and adolescents with pulmonary hypertension. Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance, 17, 81. https://doi.org/10.1186/s12968-015-0186-1
Truong U, et al. Non-invasive Determination By Cardiovascular Magnetic Resonance of Right Ventricular-vascular Coupling in Children and Adolescents With Pulmonary Hypertension. J Cardiovasc Magn Reson. 2015 Sep 16;17:81. PubMed PMID: 26376972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-invasive determination by cardiovascular magnetic resonance of right ventricular-vascular coupling in children and adolescents with pulmonary hypertension. AU - Truong,Uyen, AU - Patel,Sonali, AU - Kheyfets,Vitaly, AU - Dunning,Jamie, AU - Fonseca,Brian, AU - Barker,Alex J, AU - Ivy,Dunbar, AU - Shandas,Robin, AU - Hunter,Kendall, Y1 - 2015/09/16/ PY - 2015/04/07/received PY - 2015/08/21/accepted PY - 2015/9/18/entrez PY - 2015/9/18/pubmed PY - 2016/6/3/medline SP - 81 EP - 81 JF - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JO - J Cardiovasc Magn Reson VL - 17 N2 - BACKGROUND: Pediatric pulmonary hypertension (PH) remains a disease with high morbidity and mortality in children. Understanding ventricular-vascular coupling, a measure of how well matched the ventricular and vascular function are, may elucidate pathway leading to right heart failure. Ventricular vascular coupling ratio (VVCR), comprised of effective elastance (Ea, index of arterial load) and right ventricular maximal end-systolic elastance (Ees, index of contractility), is conventionally determined by catheterization. Here, we apply a non-invasive approach to determining VVCR in pediatric subjects with PH. METHODS: This retrospective study included PH subjects who had a cardiovascular magnetic resonance (CMR) study within 14 days of cardiac catheterization. PH was defined as mean pulmonary artery pressure (mPAP) ≥ 25 mmHg on prior or current catheterization. A non-invasive measure of VVCR was derived from CMR-only (VVCRm) and compared to VVCR estimated by catheterization-derived single beat estimation (VVCRs). Indexed pulmonary vascular resistance (PVRi) and pulmonary vascular reactivity were determined during the catheterization procedure. Pearson correlation coefficients were calculated between PVRi and VVCRm. Receiver operating characteristic (ROC) curve analysis determined the diagnostic value of VVCRm in predicting vascular reactivity. RESULTS: Seventeen subjects (3 months-23 years; mean 11.3 ± 7.4 years) were identified between January 2009-August 2013 for inclusion with equal gender distributions. Mean mPAP was 35 mmHg ± 15 and PVRi was 8.5 Woods unit x m2 ± 7.8. VVCRm (range 0.43-2.82) increased with increasing severity as defined by PVRi (p < 0.001), and was highly correlated with PVRi (r = 0.92, 95 % CI 0.79-0.97, p < 0.0001). Regression of VVCRm and PVRi demonstrated differing lines when separated by reactivity. VVCRm was significantly correlated with VVCRs (r = 0.79, CI 0.48-0.99, p <0.0001). ROC curve analysis showed high accuracy of VVCRm in determining vascular reactivity (VVCR = 0.85 had a sensitivity of 100 % and a specificity of 80 %) with an area under the curve of 0.89 (p = 0.008). CONCLUSION: Measurement of VVCRm in pediatrics is feasible. Pulmonary vascular non-reactivity may be contribute to ventricular-vascular decoupling in severe PH. Therapeutic intervention to maintain a low vascular afterload in reactive patients may preserve right ventricular functional reserve and delay the onset of RV-PA decoupling. Use of VVCRm may have significant prognostic implication. SN - 1532-429X UR - https://www.unboundmedicine.com/medline/citation/26376972/Non_invasive_determination_by_cardiovascular_magnetic_resonance_of_right_ventricular_vascular_coupling_in_children_and_adolescents_with_pulmonary_hypertension_ L2 - https://jcmr-online.biomedcentral.com/articles/10.1186/s12968-015-0186-1 DB - PRIME DP - Unbound Medicine ER -