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Sugar-containing beverage intake at the age of 1 year and cardiometabolic health at the age of 6 years: the Generation R Study.

Abstract

BACKGROUND

Consumption of sugar-containing beverages (SCBs) in adults has been associated with an increased risk of metabolic syndrome. Although the effect of SCB on body weight in children is well established, little is known about the cardiometabolic effects in young children. We studied the associations of SCB intake at the age of 1 year with cardiometabolic health at age 6 years.

METHODS

This study was performed among 2,045 Dutch children from a population based prospective birth cohort. SCB intake was assessed with a semi-quantitative food frequency questionnaire at the age of 13 months and sex-specific tertiles were created. Children visited the research center at the age of 6 years. We created a continuous cardiometabolic risk factor score including: body fat percentage, blood pressure, insulin, HDL-cholesterol and triglycerides. Age-and sex-specific standard deviation (SD) scores were created for all outcomes. Multivariable linear regression was performed with adjustment for socio-demographic and lifestyle variables of mother and child.

RESULTS

In the total population, we observed an association between higher SCB intake at 13 months of age and a higher cardiometabolic risk factor score at the age of 6 years (0.13SD (95 % CI 0.01; 0.25), highest vs. lowest tertile) After stratification by sex, we found that boys in the highest tertile of SCB intake had a higher cardiometabolic risk factor score (0.18 SD (95 % CI 0.01; 0.34)), as compared to boys in the lowest tertile of SCB intake. There was no significant association in girls. We did not find associations of SCB intake with the individual cardiometabolic risk factors in the total population, or in the stratified analyses.

CONCLUSION

Higher SCB intake at 1 year of age was associated with a higher cardiometabolic risk factor score at age 6 years in boys, but not in girls. Further research on sex-specific effects of SCBs is needed.

Authors+Show Affiliations

Generation R Study Group, University Medical Center Rotterdam, Rotterdam, The Netherlands. e.leermakers@erasmusmc.nl. Department of Epidemiology, University Medical Center Rotterdam, room Na 2909, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. e.leermakers@erasmusmc.nl. Department of Pediatrics, University Medical Center Rotterdam, Rotterdam, The Netherlands. e.leermakers@erasmusmc.nl.Generation R Study Group, University Medical Center Rotterdam, Rotterdam, The Netherlands. j.felix@erasmusmc.nl. Department of Epidemiology, University Medical Center Rotterdam, room Na 2909, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. j.felix@erasmusmc.nl. Department of Pediatrics, University Medical Center Rotterdam, Rotterdam, The Netherlands. j.felix@erasmusmc.nl.Generation R Study Group, University Medical Center Rotterdam, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl. Department of Epidemiology, University Medical Center Rotterdam, room Na 2909, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl. Department of Pediatrics, University Medical Center Rotterdam, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl.Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. h.raat@erasmusmc.nl.Generation R Study Group, University Medical Center Rotterdam, Rotterdam, The Netherlands. o.franco@erasmusmc.nl. Department of Epidemiology, University Medical Center Rotterdam, room Na 2909, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. o.franco@erasmusmc.nl.Department of Epidemiology, University Medical Center Rotterdam, room Na 2909, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. j.c.kiefte-dejong@erasmusmc.nl. Leiden University College, The Hague, The Netherlands. j.c.kiefte-dejong@erasmusmc.nl.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26377916

Citation

Leermakers, Elisabeth T M., et al. "Sugar-containing Beverage Intake at the Age of 1 Year and Cardiometabolic Health at the Age of 6 Years: the Generation R Study." The International Journal of Behavioral Nutrition and Physical Activity, vol. 12, 2015, p. 114.
Leermakers ET, Felix JF, Jaddoe VW, et al. Sugar-containing beverage intake at the age of 1 year and cardiometabolic health at the age of 6 years: the Generation R Study. Int J Behav Nutr Phys Act. 2015;12:114.
Leermakers, E. T., Felix, J. F., Jaddoe, V. W., Raat, H., Franco, O. H., & Kiefte-de Jong, J. C. (2015). Sugar-containing beverage intake at the age of 1 year and cardiometabolic health at the age of 6 years: the Generation R Study. The International Journal of Behavioral Nutrition and Physical Activity, 12, p. 114. doi:10.1186/s12966-015-0278-1.
Leermakers ET, et al. Sugar-containing Beverage Intake at the Age of 1 Year and Cardiometabolic Health at the Age of 6 Years: the Generation R Study. Int J Behav Nutr Phys Act. 2015 Sep 17;12:114. PubMed PMID: 26377916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sugar-containing beverage intake at the age of 1 year and cardiometabolic health at the age of 6 years: the Generation R Study. AU - Leermakers,Elisabeth T M, AU - Felix,Janine F, AU - Jaddoe,Vincent W V, AU - Raat,Hein, AU - Franco,Oscar H, AU - Kiefte-de Jong,Jessica C, Y1 - 2015/09/17/ PY - 2015/03/12/received PY - 2015/09/10/accepted PY - 2015/9/18/entrez PY - 2015/9/18/pubmed PY - 2016/9/20/medline SP - 114 EP - 114 JF - The international journal of behavioral nutrition and physical activity JO - Int J Behav Nutr Phys Act VL - 12 N2 - BACKGROUND: Consumption of sugar-containing beverages (SCBs) in adults has been associated with an increased risk of metabolic syndrome. Although the effect of SCB on body weight in children is well established, little is known about the cardiometabolic effects in young children. We studied the associations of SCB intake at the age of 1 year with cardiometabolic health at age 6 years. METHODS: This study was performed among 2,045 Dutch children from a population based prospective birth cohort. SCB intake was assessed with a semi-quantitative food frequency questionnaire at the age of 13 months and sex-specific tertiles were created. Children visited the research center at the age of 6 years. We created a continuous cardiometabolic risk factor score including: body fat percentage, blood pressure, insulin, HDL-cholesterol and triglycerides. Age-and sex-specific standard deviation (SD) scores were created for all outcomes. Multivariable linear regression was performed with adjustment for socio-demographic and lifestyle variables of mother and child. RESULTS: In the total population, we observed an association between higher SCB intake at 13 months of age and a higher cardiometabolic risk factor score at the age of 6 years (0.13SD (95 % CI 0.01; 0.25), highest vs. lowest tertile) After stratification by sex, we found that boys in the highest tertile of SCB intake had a higher cardiometabolic risk factor score (0.18 SD (95 % CI 0.01; 0.34)), as compared to boys in the lowest tertile of SCB intake. There was no significant association in girls. We did not find associations of SCB intake with the individual cardiometabolic risk factors in the total population, or in the stratified analyses. CONCLUSION: Higher SCB intake at 1 year of age was associated with a higher cardiometabolic risk factor score at age 6 years in boys, but not in girls. Further research on sex-specific effects of SCBs is needed. SN - 1479-5868 UR - https://www.unboundmedicine.com/medline/citation/26377916/Sugar_containing_beverage_intake_at_the_age_of_1_year_and_cardiometabolic_health_at_the_age_of_6_years:_the_Generation_R_Study_ L2 - https://ijbnpa.biomedcentral.com/articles/10.1186/s12966-015-0278-1 DB - PRIME DP - Unbound Medicine ER -