Tags

Type your tag names separated by a space and hit enter

Ureaplasma parvum and Mycoplasma genitalium are found to be significantly associated with microscopy-confirmed urethritis in a routine genitourinary medicine setting.
Int J STD AIDS 2016; 27(10):861-7IJ

Abstract

Inflammation of the urethra defined by an excess of polymorphonuclear leukocytes in the absence of sexually transmitted Chlamydia trachomatis and Neisseria gonorrhoeae is called non-chlamydial non-gonococcal urethritis (NCNGU). Although Mycoplasma genitalium is now recognised as causing a sexually transmitted infection, the clinical significance of the other Mollicute species is less clear. This study used specific real-time quantitative polymerase chain reaction assays to detect and quantify four Mollicute species, M. genitalium, M. hominis, Ureaplasma urealyticum and U. parvum, in urine specimens from men with and without NCNGU. A total of 165 urine specimens from male patients attending a genitourinary medicine clinic were eligible for the study, with microscopy-confirmed (≥5 polymorphonuclear leukocytes in urethral swab) NCNGU in 75 (45.5%) and non-confirmed NCNGU in 90 (54.5%). Chi-squared statistical analysis indicated a significantly higher prevalence of U. parvum (17.3% vs. 5.6%; p = 0.03) and M. genitalium (12% vs. 0%; p < 0.001) in NCNGU. In a subset analysis, M. genitalium was also significantly (p = 0.03) higher in men who have sex with men (MSM; 13.5%) compared to non-MSM (3.1%). No significant associations were reported for U. urealyticum and M. hominis In conclusion, this study supports a clinically significant role in NGNCU for both U. parvum and M. genitalium.

Authors+Show Affiliations

Regional Virus Laboratory, Belfast Health and Social Care Trust, Belfast, UK.Regional Virus Laboratory, Belfast Health and Social Care Trust, Belfast, UK.Regional Virus Laboratory, Belfast Health and Social Care Trust, Belfast, UK.Regional Virus Laboratory, Belfast Health and Social Care Trust, Belfast, UK peter.coyle@belfasttrust.hscni.net.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26378187

Citation

Cox, Ciara, et al. "Ureaplasma Parvum and Mycoplasma Genitalium Are Found to Be Significantly Associated With Microscopy-confirmed Urethritis in a Routine Genitourinary Medicine Setting." International Journal of STD & AIDS, vol. 27, no. 10, 2016, pp. 861-7.
Cox C, McKenna JP, Watt AP, et al. Ureaplasma parvum and Mycoplasma genitalium are found to be significantly associated with microscopy-confirmed urethritis in a routine genitourinary medicine setting. Int J STD AIDS. 2016;27(10):861-7.
Cox, C., McKenna, J. P., Watt, A. P., & Coyle, P. V. (2016). Ureaplasma parvum and Mycoplasma genitalium are found to be significantly associated with microscopy-confirmed urethritis in a routine genitourinary medicine setting. International Journal of STD & AIDS, 27(10), pp. 861-7. doi:10.1177/0956462415597620.
Cox C, et al. Ureaplasma Parvum and Mycoplasma Genitalium Are Found to Be Significantly Associated With Microscopy-confirmed Urethritis in a Routine Genitourinary Medicine Setting. Int J STD AIDS. 2016;27(10):861-7. PubMed PMID: 26378187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ureaplasma parvum and Mycoplasma genitalium are found to be significantly associated with microscopy-confirmed urethritis in a routine genitourinary medicine setting. AU - Cox,Ciara, AU - McKenna,James P, AU - Watt,Alison P, AU - Coyle,Peter V, Y1 - 2015/09/16/ PY - 2015/04/08/received PY - 2015/06/29/accepted PY - 2015/9/18/entrez PY - 2015/9/18/pubmed PY - 2017/7/1/medline KW - M. genitalium KW - Non-gonococcal non-chlamydial urethritis KW - U. parvum KW - men KW - real-time quantitative PCR KW - sexually transmitted infection SP - 861 EP - 7 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 27 IS - 10 N2 - Inflammation of the urethra defined by an excess of polymorphonuclear leukocytes in the absence of sexually transmitted Chlamydia trachomatis and Neisseria gonorrhoeae is called non-chlamydial non-gonococcal urethritis (NCNGU). Although Mycoplasma genitalium is now recognised as causing a sexually transmitted infection, the clinical significance of the other Mollicute species is less clear. This study used specific real-time quantitative polymerase chain reaction assays to detect and quantify four Mollicute species, M. genitalium, M. hominis, Ureaplasma urealyticum and U. parvum, in urine specimens from men with and without NCNGU. A total of 165 urine specimens from male patients attending a genitourinary medicine clinic were eligible for the study, with microscopy-confirmed (≥5 polymorphonuclear leukocytes in urethral swab) NCNGU in 75 (45.5%) and non-confirmed NCNGU in 90 (54.5%). Chi-squared statistical analysis indicated a significantly higher prevalence of U. parvum (17.3% vs. 5.6%; p = 0.03) and M. genitalium (12% vs. 0%; p < 0.001) in NCNGU. In a subset analysis, M. genitalium was also significantly (p = 0.03) higher in men who have sex with men (MSM; 13.5%) compared to non-MSM (3.1%). No significant associations were reported for U. urealyticum and M. hominis In conclusion, this study supports a clinically significant role in NGNCU for both U. parvum and M. genitalium. SN - 1758-1052 UR - https://www.unboundmedicine.com/medline/citation/26378187/Ureaplasma_parvum_and_Mycoplasma_genitalium_are_found_to_be_significantly_associated_with_microscopy_confirmed_urethritis_in_a_routine_genitourinary_medicine_setting_ L2 - http://journals.sagepub.com/doi/full/10.1177/0956462415597620?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -