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Thermo activated persulfate oxidation of antibiotic sulfamethoxazole and structurally related compounds.
Water Res. 2015 Dec 15; 87:1-9.WR

Abstract

The widespread occurrence of sulfonamides (e.g., sulfamethoxazole) in natural environment has raised growing concerns due to their potential to induce antibiotic-resistant genes. In this study, the degradation of SMX and related sulfonamides by thermo activated persulfate (PS) oxidation was investigated. Experimental results demonstrated that SMX degradation followed pseudo-first-order reaction kinetics. The pseudo-first-order rate constant (k(obs)) was increased markedly with increasing temperature and pH. The presence of bicarbonate manifested promoting effect on SMX degradation while fulvic acid reduced it. Radical scavenging tests revealed that the predominant oxidizing species was SO4(•-) at neutral pH. Aniline moiety in SMX molecule was confirmed to be the primary reactive site for SO4(•-) attack by comparison with substructural analogues. Reaction products were enriched by solid phase extraction (SPE) and analyzed by liquid chromatography-electrospray ionization-triple quadrupole mass spectrometry (LC-ESI-MS/MS). A total of 7 products derived from hydroxylation, sulfonamide S-N bond cleavage, aniline moiety oxidation and coupling reaction were identified, and transformation pathways of SMX oxidation were proposed. Degradation of sulfonamides was appreciably influenced by the heterocyclic ring present in the molecules. Results reveal that thermo activated PS oxidation could be an efficient approach for remediation of water contaminated by SMX and related sulfonamides.

Authors+Show Affiliations

College of Resources and Environmental Science, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: yuefeiji@njau.edu.cn.College of Resources and Environmental Science, Nanjing Agricultural University, Nanjing 210095, China.College of Resources and Environmental Science, Nanjing Agricultural University, Nanjing 210095, China.Nanjing Institute of Environmental Science, Ministry of Environmental Protection of PRC, Nanjing 210042, China.College of Resources and Environmental Science, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: jhlu@njau.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26378726

Citation

Ji, Yuefei, et al. "Thermo Activated Persulfate Oxidation of Antibiotic Sulfamethoxazole and Structurally Related Compounds." Water Research, vol. 87, 2015, pp. 1-9.
Ji Y, Fan Y, Liu K, et al. Thermo activated persulfate oxidation of antibiotic sulfamethoxazole and structurally related compounds. Water Res. 2015;87:1-9.
Ji, Y., Fan, Y., Liu, K., Kong, D., & Lu, J. (2015). Thermo activated persulfate oxidation of antibiotic sulfamethoxazole and structurally related compounds. Water Research, 87, 1-9. https://doi.org/10.1016/j.watres.2015.09.005
Ji Y, et al. Thermo Activated Persulfate Oxidation of Antibiotic Sulfamethoxazole and Structurally Related Compounds. Water Res. 2015 Dec 15;87:1-9. PubMed PMID: 26378726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thermo activated persulfate oxidation of antibiotic sulfamethoxazole and structurally related compounds. AU - Ji,Yuefei, AU - Fan,Yan, AU - Liu,Kuo, AU - Kong,Deyang, AU - Lu,Junhe, Y1 - 2015/09/09/ PY - 2015/07/01/received PY - 2015/09/01/revised PY - 2015/09/02/accepted PY - 2015/9/18/entrez PY - 2015/9/18/pubmed PY - 2016/9/9/medline KW - Reaction products KW - Sulfate radical KW - Sulfonamides KW - Thermo activated persulfate oxidation KW - Transformation mechanisms SP - 1 EP - 9 JF - Water research JO - Water Res. VL - 87 N2 - The widespread occurrence of sulfonamides (e.g., sulfamethoxazole) in natural environment has raised growing concerns due to their potential to induce antibiotic-resistant genes. In this study, the degradation of SMX and related sulfonamides by thermo activated persulfate (PS) oxidation was investigated. Experimental results demonstrated that SMX degradation followed pseudo-first-order reaction kinetics. The pseudo-first-order rate constant (k(obs)) was increased markedly with increasing temperature and pH. The presence of bicarbonate manifested promoting effect on SMX degradation while fulvic acid reduced it. Radical scavenging tests revealed that the predominant oxidizing species was SO4(•-) at neutral pH. Aniline moiety in SMX molecule was confirmed to be the primary reactive site for SO4(•-) attack by comparison with substructural analogues. Reaction products were enriched by solid phase extraction (SPE) and analyzed by liquid chromatography-electrospray ionization-triple quadrupole mass spectrometry (LC-ESI-MS/MS). A total of 7 products derived from hydroxylation, sulfonamide S-N bond cleavage, aniline moiety oxidation and coupling reaction were identified, and transformation pathways of SMX oxidation were proposed. Degradation of sulfonamides was appreciably influenced by the heterocyclic ring present in the molecules. Results reveal that thermo activated PS oxidation could be an efficient approach for remediation of water contaminated by SMX and related sulfonamides. SN - 1879-2448 UR - https://www.unboundmedicine.com/medline/citation/26378726/Thermo_activated_persulfate_oxidation_of_antibiotic_sulfamethoxazole_and_structurally_related_compounds_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0043-1354(15)30217-7 DB - PRIME DP - Unbound Medicine ER -