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Sex-specific differences in fetal growth in newborns exposed prenatally to traffic-related air pollution in the PELAGIE mother-child cohort (Brittany, France).
Environ Res. 2015 Oct; 142:680-7.ER

Abstract

BACKGROUND

Numerous studies have linked prenatal traffic-related air pollution exposure to fetal growth. Recently, several studies have suggested exploring this association independently among boys and girls because of potential sex-specific biological vulnerability to air pollution. Residence-based factors can also influence fetal growth by enhancing susceptibility to the toxic effects of air pollution and must also be considered in these relations.

OBJECTIVE

We examined sex-specific associations between prenatal air pollution exposure and fetal growth and explored whether they differed by the urban-rural status of maternal residence.

METHODS

This study relied on the PELAGIE mother-child cohort (2521 women, Brittany, France, 2002-2006). Fetal growth was assessed through birth weight, head circumference and small weight (SGA) and small head circumference (SHC) for gestational age. Nitrogen dioxide (NO2) concentrations at mothers' homes were estimated by using a land use regression model taking into account temporal variation during pregnancy. Associations between estimated NO2 concentrations and fetal growth were assessed with linear regression or logistic regression models, depending on the outcome investigated.

RESULTS

An interquartile range (8.8 µg m(-3)) increase in NO2 exposure estimates was associated with a 27.4 g (95% CI 0.8 to 55.6) increase in birth weight and a 0.09 cm (95% CI 0.00-0.17) significant increase in head circumference, among newborn boys only. Their risks of SGA and SHC were reduced (OR 0.70, 95% CI 0.53-0.92, OR 0.76, 95% CI 0.56-1.03, respectively, for an increase of 8.8 µg m(-3)). No statistically significant trends were observed among girls. Urban-rural status modified the effect of air pollution only for SHC and again only for newborn boys.

CONCLUSION

Findings from this study confirm the need to consider sex-specific associations between air pollution and fetal growth and to investigate possible mechanisms by which traffic-related air pollution may increase anthropometric parameters at birth.

Authors+Show Affiliations

INSERM U1085-IRSET, France; University of Rennes 1, Rennes, France; EHESP School of Public Health, Sorbone Paris Cité, Rennes, France.INSERM U1085-IRSET, France; University of Rennes 1, Rennes, France.INSERM U1085-IRSET, France; University of Rennes 1, Rennes, France; EHESP School of Public Health, Sorbone Paris Cité, Rennes, France.INSERM U1085-IRSET, France; University of Rennes 1, Rennes, France.INSERM U1085-IRSET, France; University of Rennes 1, Rennes, France.INSERM U1085-IRSET, France; University of Rennes 1, Rennes, France; Department of Epidemiology and Public Health, University Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France. Electronic address: jean-francois.viel@univ-rennes1.fr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26378737

Citation

Bertin, Mélanie, et al. "Sex-specific Differences in Fetal Growth in Newborns Exposed Prenatally to Traffic-related Air Pollution in the PELAGIE Mother-child Cohort (Brittany, France)." Environmental Research, vol. 142, 2015, pp. 680-7.
Bertin M, Chevrier C, Serrano T, et al. Sex-specific differences in fetal growth in newborns exposed prenatally to traffic-related air pollution in the PELAGIE mother-child cohort (Brittany, France). Environ Res. 2015;142:680-7.
Bertin, M., Chevrier, C., Serrano, T., Monfort, C., Cordier, S., & Viel, J. F. (2015). Sex-specific differences in fetal growth in newborns exposed prenatally to traffic-related air pollution in the PELAGIE mother-child cohort (Brittany, France). Environmental Research, 142, 680-7. https://doi.org/10.1016/j.envres.2015.09.006
Bertin M, et al. Sex-specific Differences in Fetal Growth in Newborns Exposed Prenatally to Traffic-related Air Pollution in the PELAGIE Mother-child Cohort (Brittany, France). Environ Res. 2015;142:680-7. PubMed PMID: 26378737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex-specific differences in fetal growth in newborns exposed prenatally to traffic-related air pollution in the PELAGIE mother-child cohort (Brittany, France). AU - Bertin,Mélanie, AU - Chevrier,Cécile, AU - Serrano,Tania, AU - Monfort,Christine, AU - Cordier,Sylvaine, AU - Viel,Jean-François, PY - 2015/05/12/received PY - 2015/09/04/revised PY - 2015/09/05/accepted PY - 2015/9/18/entrez PY - 2015/9/18/pubmed PY - 2016/2/2/medline KW - Air pollution KW - Birth weight KW - Child sex KW - Head circumference KW - Urban–rural context SP - 680 EP - 7 JF - Environmental research JO - Environ Res VL - 142 N2 - BACKGROUND: Numerous studies have linked prenatal traffic-related air pollution exposure to fetal growth. Recently, several studies have suggested exploring this association independently among boys and girls because of potential sex-specific biological vulnerability to air pollution. Residence-based factors can also influence fetal growth by enhancing susceptibility to the toxic effects of air pollution and must also be considered in these relations. OBJECTIVE: We examined sex-specific associations between prenatal air pollution exposure and fetal growth and explored whether they differed by the urban-rural status of maternal residence. METHODS: This study relied on the PELAGIE mother-child cohort (2521 women, Brittany, France, 2002-2006). Fetal growth was assessed through birth weight, head circumference and small weight (SGA) and small head circumference (SHC) for gestational age. Nitrogen dioxide (NO2) concentrations at mothers' homes were estimated by using a land use regression model taking into account temporal variation during pregnancy. Associations between estimated NO2 concentrations and fetal growth were assessed with linear regression or logistic regression models, depending on the outcome investigated. RESULTS: An interquartile range (8.8 µg m(-3)) increase in NO2 exposure estimates was associated with a 27.4 g (95% CI 0.8 to 55.6) increase in birth weight and a 0.09 cm (95% CI 0.00-0.17) significant increase in head circumference, among newborn boys only. Their risks of SGA and SHC were reduced (OR 0.70, 95% CI 0.53-0.92, OR 0.76, 95% CI 0.56-1.03, respectively, for an increase of 8.8 µg m(-3)). No statistically significant trends were observed among girls. Urban-rural status modified the effect of air pollution only for SHC and again only for newborn boys. CONCLUSION: Findings from this study confirm the need to consider sex-specific associations between air pollution and fetal growth and to investigate possible mechanisms by which traffic-related air pollution may increase anthropometric parameters at birth. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/26378737/Sex_specific_differences_in_fetal_growth_in_newborns_exposed_prenatally_to_traffic_related_air_pollution_in_the_PELAGIE_mother_child_cohort__Brittany_France__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(15)30076-1 DB - PRIME DP - Unbound Medicine ER -