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Association between coffee consumption and the risk of oral cancer: a meta-analysis of observational studies.
Int J Clin Exp Med 2015; 8(7):11657-65IJ

Abstract

OBJECTIVE

Quantification of the association between the coffee consumption and risk of oral cancer is still conflicting. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of coffee consumption with the risk of oral cancer.

METHODS

Pertinent studies were identified by a search of PubMed and Web of Knowledge to March 2015. The random effect model was used. Sensitivity analysis and publication bias were conducted.

RESULTS

Data from 12 studies including 4,037 oral cancer cases and 1,872,231 participants were used in this meta-analysis. Pooled results suggested that highest coffee consumption amount versus lowest amount was significantly associated with the risk of oral cancer [summary relative risk (RR) = 0.694, 95% CI = 0.543-0.886, I(2) = 65.0%]. The association was also significant in Europe [summary RR = 0.571, 95% CI = 0.378-0.863], but not in America. No publication bias was found.

CONCLUSIONS

Our analysis suggested that the higher coffee consumption might reduce the risk of oral cancer, especially in Europe.

Authors+Show Affiliations

Department of Emergency, School of Stomatology, China Medical University No. 117 North Nanjing Road, Shenyang 110001, China.Department of Emergency, School of Stomatology, China Medical University No. 117 North Nanjing Road, Shenyang 110001, China.Department of Emergency, School of Stomatology, China Medical University No. 117 North Nanjing Road, Shenyang 110001, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26380002

Citation

Zhang, Ying, et al. "Association Between Coffee Consumption and the Risk of Oral Cancer: a Meta-analysis of Observational Studies." International Journal of Clinical and Experimental Medicine, vol. 8, no. 7, 2015, pp. 11657-65.
Zhang Y, Wang X, Cui D. Association between coffee consumption and the risk of oral cancer: a meta-analysis of observational studies. Int J Clin Exp Med. 2015;8(7):11657-65.
Zhang, Y., Wang, X., & Cui, D. (2015). Association between coffee consumption and the risk of oral cancer: a meta-analysis of observational studies. International Journal of Clinical and Experimental Medicine, 8(7), pp. 11657-65.
Zhang Y, Wang X, Cui D. Association Between Coffee Consumption and the Risk of Oral Cancer: a Meta-analysis of Observational Studies. Int J Clin Exp Med. 2015;8(7):11657-65. PubMed PMID: 26380002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between coffee consumption and the risk of oral cancer: a meta-analysis of observational studies. AU - Zhang,Ying, AU - Wang,Xi, AU - Cui,Dan, Y1 - 2015/07/15/ PY - 2015/04/21/received PY - 2015/06/21/accepted PY - 2015/9/18/entrez PY - 2015/9/18/pubmed PY - 2015/9/18/medline KW - Coffee consumption KW - meta-analysis KW - oral cancer SP - 11657 EP - 65 JF - International journal of clinical and experimental medicine JO - Int J Clin Exp Med VL - 8 IS - 7 N2 - OBJECTIVE: Quantification of the association between the coffee consumption and risk of oral cancer is still conflicting. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of coffee consumption with the risk of oral cancer. METHODS: Pertinent studies were identified by a search of PubMed and Web of Knowledge to March 2015. The random effect model was used. Sensitivity analysis and publication bias were conducted. RESULTS: Data from 12 studies including 4,037 oral cancer cases and 1,872,231 participants were used in this meta-analysis. Pooled results suggested that highest coffee consumption amount versus lowest amount was significantly associated with the risk of oral cancer [summary relative risk (RR) = 0.694, 95% CI = 0.543-0.886, I(2) = 65.0%]. The association was also significant in Europe [summary RR = 0.571, 95% CI = 0.378-0.863], but not in America. No publication bias was found. CONCLUSIONS: Our analysis suggested that the higher coffee consumption might reduce the risk of oral cancer, especially in Europe. SN - 1940-5901 UR - https://www.unboundmedicine.com/medline/citation/26380002/Association_between_coffee_consumption_and_the_risk_of_oral_cancer:_a_meta_analysis_of_observational_studies_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26380002/ DB - PRIME DP - Unbound Medicine ER -