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Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping.
Psychopharmacology (Berl) 2015; 232(24):4445-54P

Abstract

RATIONALE

Δ(9)-Tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) found in cannabis both reduce the distressing symptom of nausea, but their combined effects are not understood.

OBJECTIVE

The potential of combined doses of THC and CBDA to reduce acute nausea and anticipatory nausea in rodent models was assessed.

MATERIALS AND METHODS

For acute nausea, the potential of cannabinoid pretreatment(s) to reduce LiCl-induced nausea paired with saccharin was evaluated in a subsequent drug free taste reactivity test, followed by a taste avoidance test. For anticipatory nausea, the potential of the cannabinoid pretreatment(s) to reduce the expression of LiCl-induced contextually elicited conditioned gaping was evaluated.

RESULTS

Combined subthreshold doses of THC (0.01 and 0.1 mg/kg) and CBDA (0.01 and 0.1 μg/kg) reduced acute nausea. Higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 μg/kg) alone, as well as these combined doses also reduced acute nausea. THC (10 mg/kg) interfered with conditioned taste avoidance, an effect attenuated by CBDA (10 μg/kg). On the other hand, combined subthreshold doses of THC (0.01 and 0.1 mg/kg) and CBDA (0.01 and 0.1 μg/kg) did not suppress contextually elicited conditioned gaping in a test for anticipatory nausea. However, higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 μg/kg) alone, as well as these combined doses, also reduced anticipatory nausea. Only at the highest dose (10 mg/kg) did THC impair locomotor activity, but CBDA did not at any dose.

CONCLUSIONS

Combined subthreshold doses of THC:CBDA are particularly effective as a treatment for acute nausea. At higher doses, CBDA may attenuate THC-induced interference with learning.

Authors+Show Affiliations

Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada. erock@uoguelph.ca.Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26381155

Citation

Rock, Erin M., et al. "Effect of Combined Doses of Δ(9)-tetrahydrocannabinol (THC) and Cannabidiolic Acid (CBDA) On Acute and Anticipatory Nausea Using Rat (Sprague- Dawley) Models of Conditioned Gaping." Psychopharmacology, vol. 232, no. 24, 2015, pp. 4445-54.
Rock EM, Limebeer CL, Parker LA. Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping. Psychopharmacology (Berl). 2015;232(24):4445-54.
Rock, E. M., Limebeer, C. L., & Parker, L. A. (2015). Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping. Psychopharmacology, 232(24), pp. 4445-54. doi:10.1007/s00213-015-4080-1.
Rock EM, Limebeer CL, Parker LA. Effect of Combined Doses of Δ(9)-tetrahydrocannabinol (THC) and Cannabidiolic Acid (CBDA) On Acute and Anticipatory Nausea Using Rat (Sprague- Dawley) Models of Conditioned Gaping. Psychopharmacology (Berl). 2015;232(24):4445-54. PubMed PMID: 26381155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping. AU - Rock,Erin M, AU - Limebeer,Cheryl L, AU - Parker,Linda A, Y1 - 2015/09/18/ PY - 2015/06/25/received PY - 2015/09/01/accepted PY - 2015/9/19/entrez PY - 2015/9/19/pubmed PY - 2016/6/28/medline KW - Acute nausea KW - Anticipatory nausea KW - CBDA KW - Conditioned taste avoidance KW - Locomotor activity KW - THC SP - 4445 EP - 54 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 232 IS - 24 N2 - RATIONALE: Δ(9)-Tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) found in cannabis both reduce the distressing symptom of nausea, but their combined effects are not understood. OBJECTIVE: The potential of combined doses of THC and CBDA to reduce acute nausea and anticipatory nausea in rodent models was assessed. MATERIALS AND METHODS: For acute nausea, the potential of cannabinoid pretreatment(s) to reduce LiCl-induced nausea paired with saccharin was evaluated in a subsequent drug free taste reactivity test, followed by a taste avoidance test. For anticipatory nausea, the potential of the cannabinoid pretreatment(s) to reduce the expression of LiCl-induced contextually elicited conditioned gaping was evaluated. RESULTS: Combined subthreshold doses of THC (0.01 and 0.1 mg/kg) and CBDA (0.01 and 0.1 μg/kg) reduced acute nausea. Higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 μg/kg) alone, as well as these combined doses also reduced acute nausea. THC (10 mg/kg) interfered with conditioned taste avoidance, an effect attenuated by CBDA (10 μg/kg). On the other hand, combined subthreshold doses of THC (0.01 and 0.1 mg/kg) and CBDA (0.01 and 0.1 μg/kg) did not suppress contextually elicited conditioned gaping in a test for anticipatory nausea. However, higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 μg/kg) alone, as well as these combined doses, also reduced anticipatory nausea. Only at the highest dose (10 mg/kg) did THC impair locomotor activity, but CBDA did not at any dose. CONCLUSIONS: Combined subthreshold doses of THC:CBDA are particularly effective as a treatment for acute nausea. At higher doses, CBDA may attenuate THC-induced interference with learning. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/26381155/Effect_of_combined_doses_of_Δ_9__tetrahydrocannabinol__THC__and_cannabidiolic_acid__CBDA__on_acute_and_anticipatory_nausea_using_rat__Sprague__Dawley__models_of_conditioned_gaping_ L2 - https://dx.doi.org/10.1007/s00213-015-4080-1 DB - PRIME DP - Unbound Medicine ER -