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Seizure Duration and Hemodynamic State During Electroconvulsive Therapy: Sodium Thiopental Versus Propofol.
Glob J Health Sci. 2015 Jun 12; 8(2):126-31.GJ

Abstract

INTRODUCTION

General anesthesia is required for Electroconvulsive Therapy (ECT) and it is usually provided by a hypnotic agent. The seizure duration is important for the treatment, and it is usually accompanied by severe hemodynamic changes. The aim of this study was to compare the effects of sodium thiopental versus Propofol on seizure duration and hemodynamic variables during ECT.

METHODS

A number of 100 patient-sessions of ECT were included in this randomized clinical trial. The initial hemodynamic state of each patient was recorded. Anesthesia was induced by Sodium thiopental in the 1st group and with Propofol in 2nd group. All the patients received the muscle relaxant succinylcholine. The hemodynamic variables after seizure and seizure duration were recorded. The data were analyzed through SPSS 20 and independent t-test. P<0.05 was considered significant.

RESULTS

The mean duration of seizure in the sodium thiopental group was significantly longer than the Propofol group (40.3±16.6 sec versus 32±11.3 sec) (P=0.001). There was no statistically significant difference between the mean energy level applied in the two groups (20.5±3.81 joules in the sodium thiopental versus 20.2±3.49 joules in the Propofol group). The mean systolic and diastolic blood pressure at all times after seizure and mean heart rate at 3 and 5 minutes after seizure were significantly lower in Propofol than sodium thiopental groups.

DISCUSSION AND CONCLUSION

Propofol provides a more stable hemodynamic state for the ECT procedures, and its use is highly preferred over sodium thiopental in patients with cardiovascular disease.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableAnesthesiology, Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. fereydoonfekrat@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26383207

Citation

Jarineshin, Hashem, et al. "Seizure Duration and Hemodynamic State During Electroconvulsive Therapy: Sodium Thiopental Versus Propofol." Global Journal of Health Science, vol. 8, no. 2, 2015, pp. 126-31.
Jarineshin H, Kashani S, Fekrat F, et al. Seizure Duration and Hemodynamic State During Electroconvulsive Therapy: Sodium Thiopental Versus Propofol. Glob J Health Sci. 2015;8(2):126-31.
Jarineshin, H., Kashani, S., Fekrat, F., Vatankhah, M., Golmirzaei, J., Alimolaee, E., & Zafarpour, H. (2015). Seizure Duration and Hemodynamic State During Electroconvulsive Therapy: Sodium Thiopental Versus Propofol. Global Journal of Health Science, 8(2), 126-31. https://doi.org/10.5539/gjhs.v8n2p126
Jarineshin H, et al. Seizure Duration and Hemodynamic State During Electroconvulsive Therapy: Sodium Thiopental Versus Propofol. Glob J Health Sci. 2015 Jun 12;8(2):126-31. PubMed PMID: 26383207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seizure Duration and Hemodynamic State During Electroconvulsive Therapy: Sodium Thiopental Versus Propofol. AU - Jarineshin,Hashem, AU - Kashani,Saeed, AU - Fekrat,Fereydoon, AU - Vatankhah,Majid, AU - Golmirzaei,Javad, AU - Alimolaee,Esmaeel, AU - Zafarpour,Hamid, Y1 - 2015/06/12/ PY - 2015/03/17/received PY - 2015/04/21/accepted PY - 2015/04/27/revised PY - 2015/9/19/entrez PY - 2015/9/19/pubmed PY - 2016/5/4/medline SP - 126 EP - 31 JF - Global journal of health science JO - Glob J Health Sci VL - 8 IS - 2 N2 - INTRODUCTION: General anesthesia is required for Electroconvulsive Therapy (ECT) and it is usually provided by a hypnotic agent. The seizure duration is important for the treatment, and it is usually accompanied by severe hemodynamic changes. The aim of this study was to compare the effects of sodium thiopental versus Propofol on seizure duration and hemodynamic variables during ECT. METHODS: A number of 100 patient-sessions of ECT were included in this randomized clinical trial. The initial hemodynamic state of each patient was recorded. Anesthesia was induced by Sodium thiopental in the 1st group and with Propofol in 2nd group. All the patients received the muscle relaxant succinylcholine. The hemodynamic variables after seizure and seizure duration were recorded. The data were analyzed through SPSS 20 and independent t-test. P<0.05 was considered significant. RESULTS: The mean duration of seizure in the sodium thiopental group was significantly longer than the Propofol group (40.3±16.6 sec versus 32±11.3 sec) (P=0.001). There was no statistically significant difference between the mean energy level applied in the two groups (20.5±3.81 joules in the sodium thiopental versus 20.2±3.49 joules in the Propofol group). The mean systolic and diastolic blood pressure at all times after seizure and mean heart rate at 3 and 5 minutes after seizure were significantly lower in Propofol than sodium thiopental groups. DISCUSSION AND CONCLUSION: Propofol provides a more stable hemodynamic state for the ECT procedures, and its use is highly preferred over sodium thiopental in patients with cardiovascular disease. SN - 1916-9736 UR - https://www.unboundmedicine.com/medline/citation/26383207/Seizure_Duration_and_Hemodynamic_State_During_Electroconvulsive_Therapy:_Sodium_Thiopental_Versus_Propofol_ L2 - https://doi.org/10.5539/gjhs.v8n2p126 DB - PRIME DP - Unbound Medicine ER -