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Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors.
Bioorg Med Chem Lett. 2015 Oct 15; 25(20):4693-6.BM

Abstract

Three groups of non-camptothecin compounds with four to five fused rings have been designed and synthesized. Their in vitro anti-proliferative activity has been evaluated with five different cancer cell lines (HCT116, PC3, U87MG, HepG2, SK-OV-3). Compounds B-2 and B-3 showed the most potent cell growth inhibition with IC50 of 169 nM and 325 nM against U87MG cell line correspondingly.

Authors+Show Affiliations

State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: xbmeng@bjmu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26384290

Citation

Zhang, Chao, et al. "Design, Synthesis and Antitumor Activity of Non-camptothecin Topoisomerase I Inhibitors." Bioorganic & Medicinal Chemistry Letters, vol. 25, no. 20, 2015, pp. 4693-6.
Zhang C, Li S, Ji L, et al. Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors. Bioorg Med Chem Lett. 2015;25(20):4693-6.
Zhang, C., Li, S., Ji, L., Liu, S., Li, Z., Li, S., & Meng, X. (2015). Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors. Bioorganic & Medicinal Chemistry Letters, 25(20), 4693-6. https://doi.org/10.1016/j.bmcl.2015.06.042
Zhang C, et al. Design, Synthesis and Antitumor Activity of Non-camptothecin Topoisomerase I Inhibitors. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4693-6. PubMed PMID: 26384290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors. AU - Zhang,Chao, AU - Li,Shasha, AU - Ji,Liyan, AU - Liu,Shan, AU - Li,Zhongjun, AU - Li,Shuchun, AU - Meng,Xiangbao, Y1 - 2015/06/26/ PY - 2015/02/26/received PY - 2015/05/27/revised PY - 2015/06/10/accepted PY - 2015/9/19/entrez PY - 2015/9/19/pubmed PY - 2016/6/18/medline KW - Anti-cancer KW - Inhibitor KW - Synthesis KW - Topo I SP - 4693 EP - 6 JF - Bioorganic & medicinal chemistry letters JO - Bioorg. Med. Chem. Lett. VL - 25 IS - 20 N2 - Three groups of non-camptothecin compounds with four to five fused rings have been designed and synthesized. Their in vitro anti-proliferative activity has been evaluated with five different cancer cell lines (HCT116, PC3, U87MG, HepG2, SK-OV-3). Compounds B-2 and B-3 showed the most potent cell growth inhibition with IC50 of 169 nM and 325 nM against U87MG cell line correspondingly. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/26384290/Design_synthesis_and_antitumor_activity_of_non_camptothecin_topoisomerase_I_inhibitors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(15)00635-6 DB - PRIME DP - Unbound Medicine ER -