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Distinct patterns of yeast cell morphology and host responses induced by representative strains of Paracoccidioides brasiliensis (Pb18) and Paracoccidioides lutzii (Pb01).
Med Mycol. 2016 Feb; 54(2):177-88.MM

Abstract

Paracoccidioidomycosis (PCM) is a systemic mycosis, widespread in Latin America. PCM is a granulomatous disease characterized by a polymorphism of lesions depending on the pathogen's virulence, the immune status of the host and its genetic susceptibility. The thermodimorphic fungus Paracoccidioides brasiliensis was considered the only etiologic agent of PCM, yet recent works have shown significant genetic diversity among different strains of P. brasiliensis. Therefore, it has been proposed for a new species within the Paracoccidioides genus, named Paracoccidioides lutzii. To better understand the fungus-host interactions elicited by strains Pb01 and Pb18 as key representatives of P. lutzii and P. brasiliensis, respectively, we carried out studies to investigate differences in morphology, induced immune response, virulence and pathology between these two Paracoccidioides species. Our results demonstrate distinct patterns of host-parasite interaction and pathology caused by Pb18 and Pb01. These results open up new fronts for NEW: clinical studies, which may result in significant consequences for the diagnosis and treatment of PCM. Considering that our results cannot be extended to all strains of both species, more studies about the virulence among Paracoccioides must be explored in the future.

Authors+Show Affiliations

Molecular Pathology Post-Graduate Program, Faculty of Medicine, University of Brasília, D.F., Brazil.Molecular Pathology Post-Graduate Program, Faculty of Medicine, University of Brasília, D.F., Brazil.Biotechnology, Institute of Tropical Pathology and Public Health, Federal University of Goiás.Molecular Pathology Post-Graduate Program, Faculty of Medicine, University of Brasília, D.F., Brazil.Molecular Pathology Post-Graduate Program, Faculty of Medicine, University of Brasília, D.F., Brazil.Biology Institute, University of Brasília, D.F., Brazil.Biology Institute, University of Brasília, D.F., Brazil.Biology Institute, Department of Entomology and Plant Pathology, Federal Rural University of Rio de Janeiro.Biology Institute, University of Brasília, D.F., Brazil.Molecular Pathology Post-Graduate Program, Faculty of Medicine, University of Brasília, D.F., Brazil.Biology Institute, University of Brasília, D.F., Brazil Genomic Science and Biotechnology Post-Graduate Program, Catholic University of Brasília, D.F., Brazil.Biology Institute, University of Brasília, D.F., Brazil.Biology Institute, University of Brasília, D.F., Brazil albocca@unb.br.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26384386

Citation

Siqueira, Isaque Medeiros, et al. "Distinct Patterns of Yeast Cell Morphology and Host Responses Induced By Representative Strains of Paracoccidioides Brasiliensis (Pb18) and Paracoccidioides Lutzii (Pb01)." Medical Mycology, vol. 54, no. 2, 2016, pp. 177-88.
Siqueira IM, Fraga CL, Amaral AC, et al. Distinct patterns of yeast cell morphology and host responses induced by representative strains of Paracoccidioides brasiliensis (Pb18) and Paracoccidioides lutzii (Pb01). Med Mycol. 2016;54(2):177-88.
Siqueira, I. M., Fraga, C. L., Amaral, A. C., Souza, A. C., Jerônimo, M. S., Correa, J. R., Magalhães, K. G., Inácio, C. A., Ribeiro, A. M., Burguel, P. H., Felipe, M. S., Tavares, A. H., & Bocca, A. L. (2016). Distinct patterns of yeast cell morphology and host responses induced by representative strains of Paracoccidioides brasiliensis (Pb18) and Paracoccidioides lutzii (Pb01). Medical Mycology, 54(2), 177-88. https://doi.org/10.1093/mmy/myv072
Siqueira IM, et al. Distinct Patterns of Yeast Cell Morphology and Host Responses Induced By Representative Strains of Paracoccidioides Brasiliensis (Pb18) and Paracoccidioides Lutzii (Pb01). Med Mycol. 2016;54(2):177-88. PubMed PMID: 26384386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distinct patterns of yeast cell morphology and host responses induced by representative strains of Paracoccidioides brasiliensis (Pb18) and Paracoccidioides lutzii (Pb01). AU - Siqueira,Isaque Medeiros, AU - Fraga,Cecília Lívia Falcomer, AU - Amaral,André Correa, AU - Souza,Ana Camila Oliveira, AU - Jerônimo,Márcio Souza, AU - Correa,José Raimundo, AU - Magalhães,Kelly Grace, AU - Inácio,Carlos Antônio, AU - Ribeiro,Alice Melo, AU - Burguel,Pedro Henrique, AU - Felipe,Maria Sueli, AU - Tavares,Aldo Henrique, AU - Bocca,Anamelia Lorenzetti, Y1 - 2015/09/17/ PY - 2015/07/07/accepted PY - 2015/06/10/received PY - 2015/9/19/entrez PY - 2015/9/19/pubmed PY - 2016/10/14/medline KW - Paracoccidioides brasiliensis KW - Paracoccidioides lutzii KW - Paracoccidioidomycosis KW - host-fungal interaction KW - morphological patterns SP - 177 EP - 88 JF - Medical mycology JO - Med. Mycol. VL - 54 IS - 2 N2 - Paracoccidioidomycosis (PCM) is a systemic mycosis, widespread in Latin America. PCM is a granulomatous disease characterized by a polymorphism of lesions depending on the pathogen's virulence, the immune status of the host and its genetic susceptibility. The thermodimorphic fungus Paracoccidioides brasiliensis was considered the only etiologic agent of PCM, yet recent works have shown significant genetic diversity among different strains of P. brasiliensis. Therefore, it has been proposed for a new species within the Paracoccidioides genus, named Paracoccidioides lutzii. To better understand the fungus-host interactions elicited by strains Pb01 and Pb18 as key representatives of P. lutzii and P. brasiliensis, respectively, we carried out studies to investigate differences in morphology, induced immune response, virulence and pathology between these two Paracoccidioides species. Our results demonstrate distinct patterns of host-parasite interaction and pathology caused by Pb18 and Pb01. These results open up new fronts for NEW: clinical studies, which may result in significant consequences for the diagnosis and treatment of PCM. Considering that our results cannot be extended to all strains of both species, more studies about the virulence among Paracoccioides must be explored in the future. SN - 1460-2709 UR - https://www.unboundmedicine.com/medline/citation/26384386/Distinct_patterns_of_yeast_cell_morphology_and_host_responses_induced_by_representative_strains_of_Paracoccidioides_brasiliensis__Pb18__and_Paracoccidioides_lutzii__Pb01__ L2 - https://academic.oup.com/mmy/article-lookup/doi/10.1093/mmy/myv072 DB - PRIME DP - Unbound Medicine ER -