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Isolated abnormal strict morphology is not a contraindication for intrauterine insemination.
Andrology 2015; 3(6):1088-93A

Abstract

This study sought to investigate whether isolated abnormal strict morphology (<5% normal forms) and very low strict morphology (0-1% normal forms) affects pregnancy rates in intrauterine insemination (IUI). This was a retrospective study performed at an Academic Medical Center/Reproductive Medicine Center. Four hundred and eight couples were included for 856 IUI cycles. 70 IUI cycles were performed in couples with abnormal strict morphology and otherwise normal semen parameters. Outcomes were measured as clinical pregnancy rate per IUI cycle as documented by fetal heart activity on maternal ultrasound. Clinical pregnancy rate did not significantly differ between the group with abnormal strict morphology [11/70 (15.7%)] and the normal morphology group [39/281 (13.9%)]. Additionally, there was no significant difference between the pregnancy rate in the abnormal morphology group compared to that of our overall institutional IUI pregnancy rate [145/856 (16.9%)]. Furthermore, there was no significant difference between pregnancy rate in the very low morphology group [3/14 (21.4%)] compared to those with normal morphology or the overall IUI pregnancy rate. Patients with isolated abnormal strict morphology have clinical pregnancy rates similar to those with normal morphology for IUI. Even in those with very low normal forms, consideration of IUI for assisted reproduction should not be excluded.

Authors+Show Affiliations

Department of Urology, Froedtert Hospital, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, USA.Department of Obstetrics and Gynecology, Froedtert Hospital, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, USA.Department of Urology, Froedtert Hospital, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, USA.Department of Obstetrics and Gynecology, Froedtert Hospital, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, USA.Department of Urology, Froedtert Hospital, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, USA.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

26384603

Citation

Lockwood, G M., et al. "Isolated Abnormal Strict Morphology Is Not a Contraindication for Intrauterine Insemination." Andrology, vol. 3, no. 6, 2015, pp. 1088-93.
Lockwood GM, Deveneau NE, Shridharani AN, et al. Isolated abnormal strict morphology is not a contraindication for intrauterine insemination. Andrology. 2015;3(6):1088-93.
Lockwood, G. M., Deveneau, N. E., Shridharani, A. N., Strawn, E. Y., & Sandlow, J. I. (2015). Isolated abnormal strict morphology is not a contraindication for intrauterine insemination. Andrology, 3(6), pp. 1088-93. doi:10.1111/andr.12098.
Lockwood GM, et al. Isolated Abnormal Strict Morphology Is Not a Contraindication for Intrauterine Insemination. Andrology. 2015;3(6):1088-93. PubMed PMID: 26384603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolated abnormal strict morphology is not a contraindication for intrauterine insemination. AU - Lockwood,G M, AU - Deveneau,N E, AU - Shridharani,A N, AU - Strawn,E Y, AU - Sandlow,J I, Y1 - 2015/09/18/ PY - 2015/01/03/received PY - 2015/07/16/revised PY - 2015/07/23/accepted PY - 2015/9/20/entrez PY - 2015/9/20/pubmed PY - 2016/11/1/medline KW - assisted reproductive technology KW - intrauterine insemination KW - male infertility KW - strict sperm morphology KW - teratozoospermia SP - 1088 EP - 93 JF - Andrology JO - Andrology VL - 3 IS - 6 N2 - This study sought to investigate whether isolated abnormal strict morphology (<5% normal forms) and very low strict morphology (0-1% normal forms) affects pregnancy rates in intrauterine insemination (IUI). This was a retrospective study performed at an Academic Medical Center/Reproductive Medicine Center. Four hundred and eight couples were included for 856 IUI cycles. 70 IUI cycles were performed in couples with abnormal strict morphology and otherwise normal semen parameters. Outcomes were measured as clinical pregnancy rate per IUI cycle as documented by fetal heart activity on maternal ultrasound. Clinical pregnancy rate did not significantly differ between the group with abnormal strict morphology [11/70 (15.7%)] and the normal morphology group [39/281 (13.9%)]. Additionally, there was no significant difference between the pregnancy rate in the abnormal morphology group compared to that of our overall institutional IUI pregnancy rate [145/856 (16.9%)]. Furthermore, there was no significant difference between pregnancy rate in the very low morphology group [3/14 (21.4%)] compared to those with normal morphology or the overall IUI pregnancy rate. Patients with isolated abnormal strict morphology have clinical pregnancy rates similar to those with normal morphology for IUI. Even in those with very low normal forms, consideration of IUI for assisted reproduction should not be excluded. SN - 2047-2927 UR - https://www.unboundmedicine.com/medline/citation/26384603/Isolated_abnormal_strict_morphology_is_not_a_contraindication_for_intrauterine_insemination_ L2 - https://doi.org/10.1111/andr.12098 DB - PRIME DP - Unbound Medicine ER -