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The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome.
Eur J Nutr 2016; 55(8):2357-2364EJ

Abstract

BACKGROUND

Limited data are available indicating the effects of coenzyme Q10 (CoQ10) supplementation on metabolic status of patients with metabolic syndrome (MetS).

PURPOSE

The present study was conducted to determine the effects of CoQ10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress among patients with MetS.

METHODS

This randomized, double-blind, placebo-controlled trial was performed among 60 overweight or obese and type 2 diabetes mellitus patients with coronary heart disease aged 40-85 years old. Participants were randomly allocated into two groups. Group A (n = 30) received 100 mg CoQ10 supplements and group B (n = 30) received placebo for 8 weeks. Fasting blood samples were taken at the beginning of the study and after 8-week intervention to quantify glucose homeostasis parameters, lipid profiles and biomarkers of inflammation and oxidative stress.

RESULTS

Compared with the placebo, CoQ10 supplementation resulted in a significant reduction in serum insulin levels (-2.1 ± 7.1 vs. +4.1 ± 7.8 µIU/mL, P = 0.002) and homeostasis model of assessment-insulin resistance (-0.7 ± 2.1 vs. +1.0 ± 2.0, P = 0.002) and homeostatic model assessment-beta cell function (-5.9 ± 22.2 vs. +15.9 ± 34.0, P = 0.005). In addition, patients who received CoQ10 supplements had a significant increase in plasma total antioxidant capacity (TAC) concentrations (+26.0 ± 105.0 vs. -162.2 ± 361.8 mmol/L, P = 0.008) compared with the placebo group. However, after adjustment for the baseline levels, age and baseline BMI, the effect on TAC levels (P = 0.08) disappeared. Additionally, compared with the placebo group, a significant positive trends in plasma glutathione (P = 0.06) and a significant reduction in malondialdehyde (P = 0.08) were seen among patients who received CoQ10 supplement. We did not observe any significant changes in fasting plasma glucose, lipid concentrations and inflammatory markers.

CONCLUSIONS

Overall, daily intake of 100 mg CoQ10 supplements among patients with MetS for 8 weeks had beneficial effects on serum insulin levels, HOMA-IR, HOMA-B and plasma TAC concentrations.

CLINICAL TRIAL REGISTRATION NUMBER

www.irct.ir : IRCT201502245623N35.

Authors+Show Affiliations

Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. asemi_r@yahoo.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26385228

Citation

Raygan, Fariba, et al. "The Effects of Coenzyme Q10 Administration On Glucose Homeostasis Parameters, Lipid Profiles, Biomarkers of Inflammation and Oxidative Stress in Patients With Metabolic Syndrome." European Journal of Nutrition, vol. 55, no. 8, 2016, pp. 2357-2364.
Raygan F, Rezavandi Z, Dadkhah Tehrani S, et al. The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome. Eur J Nutr. 2016;55(8):2357-2364.
Raygan, F., Rezavandi, Z., Dadkhah Tehrani, S., Farrokhian, A., & Asemi, Z. (2016). The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome. European Journal of Nutrition, 55(8), pp. 2357-2364.
Raygan F, et al. The Effects of Coenzyme Q10 Administration On Glucose Homeostasis Parameters, Lipid Profiles, Biomarkers of Inflammation and Oxidative Stress in Patients With Metabolic Syndrome. Eur J Nutr. 2016;55(8):2357-2364. PubMed PMID: 26385228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome. AU - Raygan,Fariba, AU - Rezavandi,Zohreh, AU - Dadkhah Tehrani,Sahar, AU - Farrokhian,Alireza, AU - Asemi,Zatollah, Y1 - 2015/09/18/ PY - 2015/07/02/received PY - 2015/09/10/accepted PY - 2015/9/20/pubmed PY - 2017/4/11/medline PY - 2015/9/20/entrez KW - Coenzyme Q10 KW - Coronary heart disease KW - Metabolic syndrome KW - Supplementation KW - Type 2 diabetes mellitus SP - 2357 EP - 2364 JF - European journal of nutrition JO - Eur J Nutr VL - 55 IS - 8 N2 - BACKGROUND: Limited data are available indicating the effects of coenzyme Q10 (CoQ10) supplementation on metabolic status of patients with metabolic syndrome (MetS). PURPOSE: The present study was conducted to determine the effects of CoQ10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress among patients with MetS. METHODS: This randomized, double-blind, placebo-controlled trial was performed among 60 overweight or obese and type 2 diabetes mellitus patients with coronary heart disease aged 40-85 years old. Participants were randomly allocated into two groups. Group A (n = 30) received 100 mg CoQ10 supplements and group B (n = 30) received placebo for 8 weeks. Fasting blood samples were taken at the beginning of the study and after 8-week intervention to quantify glucose homeostasis parameters, lipid profiles and biomarkers of inflammation and oxidative stress. RESULTS: Compared with the placebo, CoQ10 supplementation resulted in a significant reduction in serum insulin levels (-2.1 ± 7.1 vs. +4.1 ± 7.8 µIU/mL, P = 0.002) and homeostasis model of assessment-insulin resistance (-0.7 ± 2.1 vs. +1.0 ± 2.0, P = 0.002) and homeostatic model assessment-beta cell function (-5.9 ± 22.2 vs. +15.9 ± 34.0, P = 0.005). In addition, patients who received CoQ10 supplements had a significant increase in plasma total antioxidant capacity (TAC) concentrations (+26.0 ± 105.0 vs. -162.2 ± 361.8 mmol/L, P = 0.008) compared with the placebo group. However, after adjustment for the baseline levels, age and baseline BMI, the effect on TAC levels (P = 0.08) disappeared. Additionally, compared with the placebo group, a significant positive trends in plasma glutathione (P = 0.06) and a significant reduction in malondialdehyde (P = 0.08) were seen among patients who received CoQ10 supplement. We did not observe any significant changes in fasting plasma glucose, lipid concentrations and inflammatory markers. CONCLUSIONS: Overall, daily intake of 100 mg CoQ10 supplements among patients with MetS for 8 weeks had beneficial effects on serum insulin levels, HOMA-IR, HOMA-B and plasma TAC concentrations. CLINICAL TRIAL REGISTRATION NUMBER: www.irct.ir : IRCT201502245623N35. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/26385228/The_effects_of_coenzyme_Q10_administration_on_glucose_homeostasis_parameters_lipid_profiles_biomarkers_of_inflammation_and_oxidative_stress_in_patients_with_metabolic_syndrome_ L2 - https://dx.doi.org/10.1007/s00394-015-1042-7 DB - PRIME DP - Unbound Medicine ER -