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Role of sebaceous glands in inflammatory dermatoses.
J Am Acad Dermatol. 2015 Nov; 73(5):856-63.JA

Abstract

Skin is an important interface between the host and its environment. Inflammatory dermatoses often have disrupted skin barrier function, rendering patients more susceptible to allergenic triggers leading to an exaggerated immune response. The skin surface lipid film, an important component of the skin barrier, comprises a mixture of keratinocyte and sebaceous gland-derived lipids. Recent evidence demonstrated that defective keratinocyte lipid synthesis predisposes for the development of atopic dermatitis. However, the important role of sebaceous gland-derived lipids in skin inflammatory diseases may be underrecognized. This overview focuses on the importance of the contribution of sebaceous glands to barrier function. Sebaceous gland alteration may play a role in the pathogenesis of common skin diseases including acne vulgaris, atopic dermatitis, psoriasis, rosacea, and seborrheic dermatitis.

Authors+Show Affiliations

Department of Dermatology, University of California, Davis, California.School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.School of Medicine, University of California, Davis, California.David Geffen School of Medicine, University of California, Los Angeles, California.Department of Dermatology, University of California, San Francisco, California.Department of Dermatology, University of California, Davis, California. Electronic address: rksivamani@ucdavis.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26386632

Citation

Shi, Vivian Y., et al. "Role of Sebaceous Glands in Inflammatory Dermatoses." Journal of the American Academy of Dermatology, vol. 73, no. 5, 2015, pp. 856-63.
Shi VY, Leo M, Hassoun L, et al. Role of sebaceous glands in inflammatory dermatoses. J Am Acad Dermatol. 2015;73(5):856-63.
Shi, V. Y., Leo, M., Hassoun, L., Chahal, D. S., Maibach, H. I., & Sivamani, R. K. (2015). Role of sebaceous glands in inflammatory dermatoses. Journal of the American Academy of Dermatology, 73(5), 856-63. https://doi.org/10.1016/j.jaad.2015.08.015
Shi VY, et al. Role of Sebaceous Glands in Inflammatory Dermatoses. J Am Acad Dermatol. 2015;73(5):856-63. PubMed PMID: 26386632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of sebaceous glands in inflammatory dermatoses. AU - Shi,Vivian Y, AU - Leo,Michael, AU - Hassoun,Lauren, AU - Chahal,Dev S, AU - Maibach,Howard I, AU - Sivamani,Raja K, Y1 - 2015/09/18/ PY - 2015/03/10/received PY - 2015/08/10/revised PY - 2015/08/11/accepted PY - 2015/9/21/entrez PY - 2015/9/21/pubmed PY - 2016/1/23/medline KW - acne KW - atopic dermatitis KW - eczema KW - psoriasis KW - rosacea KW - sebocytes KW - seborrheic dermatitis KW - sebum SP - 856 EP - 63 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 73 IS - 5 N2 - Skin is an important interface between the host and its environment. Inflammatory dermatoses often have disrupted skin barrier function, rendering patients more susceptible to allergenic triggers leading to an exaggerated immune response. The skin surface lipid film, an important component of the skin barrier, comprises a mixture of keratinocyte and sebaceous gland-derived lipids. Recent evidence demonstrated that defective keratinocyte lipid synthesis predisposes for the development of atopic dermatitis. However, the important role of sebaceous gland-derived lipids in skin inflammatory diseases may be underrecognized. This overview focuses on the importance of the contribution of sebaceous glands to barrier function. Sebaceous gland alteration may play a role in the pathogenesis of common skin diseases including acne vulgaris, atopic dermatitis, psoriasis, rosacea, and seborrheic dermatitis. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/26386632/Role_of_sebaceous_glands_in_inflammatory_dermatoses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(15)02016-2 DB - PRIME DP - Unbound Medicine ER -