Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats.
Metabolism. 2015 Dec; 64(12):1658-66.M

Abstract

OBJECTIVE

Absorption of long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to be potentiated when consumed with a high fat meal. However, the effect of different dietary fats on n-3PUFA absorption and postprandial kinetics has not been previously studied.

METHOD

In a randomized cross-over design intervention, postprandial incorporation of LCn-3PUFA into plasma lipids following consumption of a meal rich in either saturated fat or omega-6 polyunsaturated fatty acids (n-6PUFA) was investigated. Healthy adult male and female subjects (n=26) were fed an isocaloric meal containing equivalent amount of either butter or sunflower seed oil supplemented with 1.8grams of LCn-3PUFA (300mg eicosapentaenoic acid, 20:5n-3 and 1500mg docosahexaenoic acid, 22:6n-3).

RESULTS

Postprandial plasma lipids were enriched with saturated fatty acids and linoleic acid (18:2n-6) following consumption of the butter and the sunflower oil containing meals respectively. The increase in plasma 20:5n-3 and 22:6n-3 levels over the 6hour study period was similar in both the saturated and the n-6 fat groups.

CONCLUSION

These results suggest that the expected competition between LCn-3PUFA and n-6PUFA at the absorption level is unlikely; therefore competition at the enzymatic level should be primarily responsible for differences in their metabolic and clinical effects. Trial registered with the Australia New Zealand Trial registry as ACTRN12612000654853.

Links

Publisher Full Text

Aggregator Full Text

Authors+Show Affiliations

Dias CB

Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia; Hunter Medical Research Institute, University of Newcastle, Australia. Electronic address: cintia.dias@uon.edu.au.

Wood LG

Hunter Medical Research Institute, University of Newcastle, Australia; Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia. Electronic address: lisa.wood@newcastle.edu.au.

Phang M

Garg ML

MeSH

AdolescentAdultAgedCross-Over StudiesFatty Acids, Omega-3Fatty Acids, Omega-6FemaleHumansKineticsLipidsMaleMiddle AgedSex Characteristics

Pub Type(s)

Journal Article

Randomized Controlled Trial

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26386693

Citation

Dias, Cintia B., et al. "Kinetics of Omega-3 Polyunsaturated Fatty Acids when Co-administered With Saturated or Omega-6 Fats." Metabolism: Clinical and Experimental, vol. 64, no. 12, 2015, pp. 1658-66.

Dias CB, Wood LG, Phang M, et al. Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats. Metabolism. 2015;64(12):1658-66.

Dias, C. B., Wood, L. G., Phang, M., & Garg, M. L. (2015). Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats. Metabolism: Clinical and Experimental, 64(12), 1658-66. https://doi.org/10.1016/j.metabol.2015.08.012

Dias CB, et al. Kinetics of Omega-3 Polyunsaturated Fatty Acids when Co-administered With Saturated or Omega-6 Fats. Metabolism. 2015;64(12):1658-66. PubMed PMID: 26386693.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats. AU - Dias,Cintia B, AU - Wood,Lisa G, AU - Phang,Melinda, AU - Garg,Manohar Lal, Y1 - 2015/08/28/ PY - 2015/05/07/received PY - 2015/08/06/revised PY - 2015/08/23/accepted PY - 2015/9/21/entrez PY - 2015/9/21/pubmed PY - 2016/2/26/medline KW - Plasma fatty acids KW - Postprandial effects KW - Saturated fatty acids KW - n-3 polyunsaturated fatty acids KW - n-6 polyunsaturated fatty acids SP - 1658 EP - 66 JF - Metabolism: clinical and experimental JO - Metabolism VL - 64 IS - 12 N2 - OBJECTIVE: Absorption of long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to be potentiated when consumed with a high fat meal. However, the effect of different dietary fats on n-3PUFA absorption and postprandial kinetics has not been previously studied. METHOD: In a randomized cross-over design intervention, postprandial incorporation of LCn-3PUFA into plasma lipids following consumption of a meal rich in either saturated fat or omega-6 polyunsaturated fatty acids (n-6PUFA) was investigated. Healthy adult male and female subjects (n=26) were fed an isocaloric meal containing equivalent amount of either butter or sunflower seed oil supplemented with 1.8grams of LCn-3PUFA (300mg eicosapentaenoic acid, 20:5n-3 and 1500mg docosahexaenoic acid, 22:6n-3). RESULTS: Postprandial plasma lipids were enriched with saturated fatty acids and linoleic acid (18:2n-6) following consumption of the butter and the sunflower oil containing meals respectively. The increase in plasma 20:5n-3 and 22:6n-3 levels over the 6hour study period was similar in both the saturated and the n-6 fat groups. CONCLUSION: These results suggest that the expected competition between LCn-3PUFA and n-6PUFA at the absorption level is unlikely; therefore competition at the enzymatic level should be primarily responsible for differences in their metabolic and clinical effects. Trial registered with the Australia New Zealand Trial registry as ACTRN12612000654853. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/26386693/Kinetics_of_omega_3_polyunsaturated_fatty_acids_when_co_administered_with_saturated_or_omega_6_fats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(15)00245-0 DB - PRIME DP - Unbound Medicine ER -

Tags

Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats.Metabolism. 2015 Dec; 64(12):1658-66.M