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Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats.
Metabolism 2015; 64(12):1658-66M

Abstract

OBJECTIVE

Absorption of long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to be potentiated when consumed with a high fat meal. However, the effect of different dietary fats on n-3PUFA absorption and postprandial kinetics has not been previously studied.

METHOD

In a randomized cross-over design intervention, postprandial incorporation of LCn-3PUFA into plasma lipids following consumption of a meal rich in either saturated fat or omega-6 polyunsaturated fatty acids (n-6PUFA) was investigated. Healthy adult male and female subjects (n=26) were fed an isocaloric meal containing equivalent amount of either butter or sunflower seed oil supplemented with 1.8grams of LCn-3PUFA (300mg eicosapentaenoic acid, 20:5n-3 and 1500mg docosahexaenoic acid, 22:6n-3).

RESULTS

Postprandial plasma lipids were enriched with saturated fatty acids and linoleic acid (18:2n-6) following consumption of the butter and the sunflower oil containing meals respectively. The increase in plasma 20:5n-3 and 22:6n-3 levels over the 6hour study period was similar in both the saturated and the n-6 fat groups.

CONCLUSION

These results suggest that the expected competition between LCn-3PUFA and n-6PUFA at the absorption level is unlikely; therefore competition at the enzymatic level should be primarily responsible for differences in their metabolic and clinical effects. Trial registered with the Australia New Zealand Trial registry as ACTRN12612000654853.

Authors+Show Affiliations

Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia; Hunter Medical Research Institute, University of Newcastle, Australia. Electronic address: cintia.dias@uon.edu.au.Hunter Medical Research Institute, University of Newcastle, Australia; Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia. Electronic address: lisa.wood@newcastle.edu.au.Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia; Hunter Medical Research Institute, University of Newcastle, Australia. Electronic address: melinda.phang@health.sa.gov.au.Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia; Hunter Medical Research Institute, University of Newcastle, Australia. Electronic address: manohar.garg@newcastle.edu.au.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26386693

Citation

Dias, Cintia B., et al. "Kinetics of Omega-3 Polyunsaturated Fatty Acids when Co-administered With Saturated or Omega-6 Fats." Metabolism: Clinical and Experimental, vol. 64, no. 12, 2015, pp. 1658-66.
Dias CB, Wood LG, Phang M, et al. Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats. Metab Clin Exp. 2015;64(12):1658-66.
Dias, C. B., Wood, L. G., Phang, M., & Garg, M. L. (2015). Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats. Metabolism: Clinical and Experimental, 64(12), pp. 1658-66. doi:10.1016/j.metabol.2015.08.012.
Dias CB, et al. Kinetics of Omega-3 Polyunsaturated Fatty Acids when Co-administered With Saturated or Omega-6 Fats. Metab Clin Exp. 2015;64(12):1658-66. PubMed PMID: 26386693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats. AU - Dias,Cintia B, AU - Wood,Lisa G, AU - Phang,Melinda, AU - Garg,Manohar Lal, Y1 - 2015/08/28/ PY - 2015/05/07/received PY - 2015/08/06/revised PY - 2015/08/23/accepted PY - 2015/9/21/entrez PY - 2015/9/21/pubmed PY - 2016/2/26/medline KW - Plasma fatty acids KW - Postprandial effects KW - Saturated fatty acids KW - n-3 polyunsaturated fatty acids KW - n-6 polyunsaturated fatty acids SP - 1658 EP - 66 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 64 IS - 12 N2 - OBJECTIVE: Absorption of long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to be potentiated when consumed with a high fat meal. However, the effect of different dietary fats on n-3PUFA absorption and postprandial kinetics has not been previously studied. METHOD: In a randomized cross-over design intervention, postprandial incorporation of LCn-3PUFA into plasma lipids following consumption of a meal rich in either saturated fat or omega-6 polyunsaturated fatty acids (n-6PUFA) was investigated. Healthy adult male and female subjects (n=26) were fed an isocaloric meal containing equivalent amount of either butter or sunflower seed oil supplemented with 1.8grams of LCn-3PUFA (300mg eicosapentaenoic acid, 20:5n-3 and 1500mg docosahexaenoic acid, 22:6n-3). RESULTS: Postprandial plasma lipids were enriched with saturated fatty acids and linoleic acid (18:2n-6) following consumption of the butter and the sunflower oil containing meals respectively. The increase in plasma 20:5n-3 and 22:6n-3 levels over the 6hour study period was similar in both the saturated and the n-6 fat groups. CONCLUSION: These results suggest that the expected competition between LCn-3PUFA and n-6PUFA at the absorption level is unlikely; therefore competition at the enzymatic level should be primarily responsible for differences in their metabolic and clinical effects. Trial registered with the Australia New Zealand Trial registry as ACTRN12612000654853. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/26386693/Kinetics_of_omega_3_polyunsaturated_fatty_acids_when_co_administered_with_saturated_or_omega_6_fats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(15)00245-0 DB - PRIME DP - Unbound Medicine ER -