Abstract
OBJECTIVE
Absorption of long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to be potentiated when consumed with a high fat meal. However, the effect of different dietary fats on n-3PUFA absorption and postprandial kinetics has not been previously studied.
METHOD
In a randomized cross-over design intervention, postprandial incorporation of LCn-3PUFA into plasma lipids following consumption of a meal rich in either saturated fat or omega-6 polyunsaturated fatty acids (n-6PUFA) was investigated. Healthy adult male and female subjects (n=26) were fed an isocaloric meal containing equivalent amount of either butter or sunflower seed oil supplemented with 1.8grams of LCn-3PUFA (300mg eicosapentaenoic acid, 20:5n-3 and 1500mg docosahexaenoic acid, 22:6n-3).
RESULTS
Postprandial plasma lipids were enriched with saturated fatty acids and linoleic acid (18:2n-6) following consumption of the butter and the sunflower oil containing meals respectively. The increase in plasma 20:5n-3 and 22:6n-3 levels over the 6hour study period was similar in both the saturated and the n-6 fat groups.
CONCLUSION
These results suggest that the expected competition between LCn-3PUFA and n-6PUFA at the absorption level is unlikely; therefore competition at the enzymatic level should be primarily responsible for differences in their metabolic and clinical effects. Trial registered with the Australia New Zealand Trial registry as ACTRN12612000654853.
Pub Type(s)
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
TY - JOUR
T1 - Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats.
AU - Dias,Cintia B,
AU - Wood,Lisa G,
AU - Phang,Melinda,
AU - Garg,Manohar Lal,
Y1 - 2015/08/28/
PY - 2015/05/07/received
PY - 2015/08/06/revised
PY - 2015/08/23/accepted
PY - 2015/9/21/entrez
PY - 2015/9/21/pubmed
PY - 2016/2/26/medline
KW - Plasma fatty acids
KW - Postprandial effects
KW - Saturated fatty acids
KW - n-3 polyunsaturated fatty acids
KW - n-6 polyunsaturated fatty acids
SP - 1658
EP - 66
JF - Metabolism: clinical and experimental
JO - Metabolism
VL - 64
IS - 12
N2 - OBJECTIVE: Absorption of long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to be potentiated when consumed with a high fat meal. However, the effect of different dietary fats on n-3PUFA absorption and postprandial kinetics has not been previously studied. METHOD: In a randomized cross-over design intervention, postprandial incorporation of LCn-3PUFA into plasma lipids following consumption of a meal rich in either saturated fat or omega-6 polyunsaturated fatty acids (n-6PUFA) was investigated. Healthy adult male and female subjects (n=26) were fed an isocaloric meal containing equivalent amount of either butter or sunflower seed oil supplemented with 1.8grams of LCn-3PUFA (300mg eicosapentaenoic acid, 20:5n-3 and 1500mg docosahexaenoic acid, 22:6n-3). RESULTS: Postprandial plasma lipids were enriched with saturated fatty acids and linoleic acid (18:2n-6) following consumption of the butter and the sunflower oil containing meals respectively. The increase in plasma 20:5n-3 and 22:6n-3 levels over the 6hour study period was similar in both the saturated and the n-6 fat groups. CONCLUSION: These results suggest that the expected competition between LCn-3PUFA and n-6PUFA at the absorption level is unlikely; therefore competition at the enzymatic level should be primarily responsible for differences in their metabolic and clinical effects. Trial registered with the Australia New Zealand Trial registry as ACTRN12612000654853.
SN - 1532-8600
UR - https://www.unboundmedicine.com/medline/citation/26386693/Kinetics_of_omega_3_polyunsaturated_fatty_acids_when_co_administered_with_saturated_or_omega_6_fats_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(15)00245-0
DB - PRIME
DP - Unbound Medicine
ER -