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Apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms are correlated with an increased risk of coronary heart disease: a case-control and meta-analysis study.
Lipids Health Dis. 2015 Sep 19; 14:113.LH

Abstract

BACKGROUND

Triglycerides (TGs) are proatherogenic lipoproteins involving the risk of coronary heart disease (CHD), while apolipoprotein A5 (APOA5) and apolipoprotein C3 (APOC3) are main lipoproteins composing TG-rich lipoproteins. In this study, we aim to explore the correlation of CHD with APOA5 -1131 T > C and APOC3 -455 T > C single nucleotide polymorphisms (SNPs).

METHODS

A sum of 210 CHD patients, hospitalized between Jan. 2013 and Mar. 2015 at China-Japan Union Hospital, Jilin University, were selected as our case group and 223 healthy individuals who had physical examination at same hospital at the same period were selected as control group. The frequency distribution of genotypes of APOA5 -1131 T > C and APOC3 -455 T > C SNPs were measured by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The Stata 12.0 software was utilized for statistical analyses.

RESULTS

There was no significant difference on age and sex between case and control group (P > 0.05). History of smoking, drinking, hypertension and diabetes mellitus, body mass index and levels of TG and fasting blood sugar in case group were shown to be higher than control group (P < 0.05), while levels of total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in case group were lower than control group (P < 0.05). Both CC and TC' + CC frequencies of APOA5 -1131 T > C and APOC3 -455 T > C in case group were higher compared to control group (both P < 0.05). Additionally, T allele frequencies of the two SNPs in case group were lower than control group, while C allele in case group has higher frequencies compared to control group (both P < 0.05). The results of meta-analysis under allele and dominant models showed that APOA5 -1131 T > C and APOC3 -455 T > C SNPs are likely to increase the risk of CHD (both P < 0.05).

CONCLUSION

APOA5 -1131 T > C and APOC3 -455 T > C SNPs may play potent roles in the development and progression of CHD.

Authors+Show Affiliations

Department of Molecular Biology, College of Basic Medical Science, Jilin University, Changchun, 130000, P.R. China.Department of Internal Medicine-Cardiovascular, the Fourth Affiliated Hospital of China Medical University, Changchun, 130000, P.R. China.Department of Neurosurgery, FAW General Hospital, Jilin University, Changchun, 130000, P.R. China.Department of Cardiology, China-Japan Union Hospital, Jilin University, No. 126 Xiantai Stree, Changchun, 130000, P.R. China.Department of Cardiology, China-Japan Union Hospital, Jilin University, No. 126 Xiantai Stree, Changchun, 130000, P.R. China. anzhe@jlu.edu.cn.Department of Internal Medicine-Cardiovascular, the Fourth Affiliated Hospital of China Medical University, Changchun, 130000, P.R. China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26387083

Citation

Yang, Guang, et al. "Apolipoprotein A5 and Apolipoprotein C3 Single Nucleotide Polymorphisms Are Correlated With an Increased Risk of Coronary Heart Disease: a Case-control and Meta-analysis Study." Lipids in Health and Disease, vol. 14, 2015, p. 113.
Yang G, Lei MM, Yu CL, et al. Apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms are correlated with an increased risk of coronary heart disease: a case-control and meta-analysis study. Lipids Health Dis. 2015;14:113.
Yang, G., Lei, M. M., Yu, C. L., Liu, X. X., An, Z., & Song, C. L. (2015). Apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms are correlated with an increased risk of coronary heart disease: a case-control and meta-analysis study. Lipids in Health and Disease, 14, 113. https://doi.org/10.1186/s12944-015-0110-6
Yang G, et al. Apolipoprotein A5 and Apolipoprotein C3 Single Nucleotide Polymorphisms Are Correlated With an Increased Risk of Coronary Heart Disease: a Case-control and Meta-analysis Study. Lipids Health Dis. 2015 Sep 19;14:113. PubMed PMID: 26387083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms are correlated with an increased risk of coronary heart disease: a case-control and meta-analysis study. AU - Yang,Guang, AU - Lei,Ming-Ming, AU - Yu,Chun-Lei, AU - Liu,Xiao-Xiao, AU - An,Zhe, AU - Song,Chun-Li, Y1 - 2015/09/19/ PY - 2014/12/11/received PY - 2015/08/28/accepted PY - 2015/9/21/entrez PY - 2015/9/21/pubmed PY - 2016/7/2/medline SP - 113 EP - 113 JF - Lipids in health and disease JO - Lipids Health Dis VL - 14 N2 - BACKGROUND: Triglycerides (TGs) are proatherogenic lipoproteins involving the risk of coronary heart disease (CHD), while apolipoprotein A5 (APOA5) and apolipoprotein C3 (APOC3) are main lipoproteins composing TG-rich lipoproteins. In this study, we aim to explore the correlation of CHD with APOA5 -1131 T > C and APOC3 -455 T > C single nucleotide polymorphisms (SNPs). METHODS: A sum of 210 CHD patients, hospitalized between Jan. 2013 and Mar. 2015 at China-Japan Union Hospital, Jilin University, were selected as our case group and 223 healthy individuals who had physical examination at same hospital at the same period were selected as control group. The frequency distribution of genotypes of APOA5 -1131 T > C and APOC3 -455 T > C SNPs were measured by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The Stata 12.0 software was utilized for statistical analyses. RESULTS: There was no significant difference on age and sex between case and control group (P > 0.05). History of smoking, drinking, hypertension and diabetes mellitus, body mass index and levels of TG and fasting blood sugar in case group were shown to be higher than control group (P < 0.05), while levels of total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in case group were lower than control group (P < 0.05). Both CC and TC' + CC frequencies of APOA5 -1131 T > C and APOC3 -455 T > C in case group were higher compared to control group (both P < 0.05). Additionally, T allele frequencies of the two SNPs in case group were lower than control group, while C allele in case group has higher frequencies compared to control group (both P < 0.05). The results of meta-analysis under allele and dominant models showed that APOA5 -1131 T > C and APOC3 -455 T > C SNPs are likely to increase the risk of CHD (both P < 0.05). CONCLUSION: APOA5 -1131 T > C and APOC3 -455 T > C SNPs may play potent roles in the development and progression of CHD. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/26387083/Apolipoprotein_A5_and_apolipoprotein_C3_single_nucleotide_polymorphisms_are_correlated_with_an_increased_risk_of_coronary_heart_disease:_a_case_control_and_meta_analysis_study_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-015-0110-6 DB - PRIME DP - Unbound Medicine ER -