Tags

Type your tag names separated by a space and hit enter

Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.
J Clin Biochem Nutr 2015; 57(2):129-34JC

Abstract

We assessed the effect of multi-species probiotic mixture on the changes in fecal microbiota and irritable bowel syndrome (IBS) symptoms. Eighty-one IBS patients were randomly assigned to receive either probiotic mixture (n = 39; containing Lactobacillus acidophilus, L. rhamnosus, Bifidobacterium breve, B. actis, B. longum, and Streptococcus thermophilus) or placebo (n = 42) for 4 weeks. A questionnaire regarding general symptom relief was administered. The change in total symptom scores (sum of 10 IBS symptoms) and subtotal scores in 4 domains (pain, constipation, diarrhea, and bloating/gas) were evaluated. The change in fecal flora was determined by quantitative real-time PCR. The concentration of probiotic strains significantly increased after ingestion in probiotics group (B. bifidum, p = 0.043; B. lactis, p<0.001; L. acidophilus, p = 0.016; L. rhamnosus, p<0.001). The proportion of patients with adequate symptom relief was higher in probiotics group than in placebo group (74.4% vs 61.9%, p = 0.230). The decrease in total symptom score over time was not significantly different between the groups (p = 0.703). Among subtotal scores of 4 IBS symptom domains, the time effect was significantly different for diarrhea-symptom score between the groups (p = 0.017). A 4-week administration of multi-species probiotic mixture significantly increased the fecal concentration of most probiotic strains and improved diarrhea-symptom scores in IBS patients.

Authors+Show Affiliations

Departments of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do 463-707, Korea.Departments of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do 463-707, Korea.Departments of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do 463-707, Korea ; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-744, Korea.Cell Biotech, Co., Ltd., Seoul 415-872, Korea.Departments of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do 463-707, Korea.Departments of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do 463-707, Korea ; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-744, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26388670

Citation

Yoon, Hyuk, et al. "Effect of Administering a Multi-species Probiotic Mixture On the Changes in Fecal Microbiota and Symptoms of Irritable Bowel Syndrome: a Randomized, Double-blind, Placebo-controlled Trial." Journal of Clinical Biochemistry and Nutrition, vol. 57, no. 2, 2015, pp. 129-34.
Yoon H, Park YS, Lee DH, et al. Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Biochem Nutr. 2015;57(2):129-34.
Yoon, H., Park, Y. S., Lee, D. H., Seo, J. G., Shin, C. M., & Kim, N. (2015). Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. Journal of Clinical Biochemistry and Nutrition, 57(2), pp. 129-34. doi:10.3164/jcbn.15-14.
Yoon H, et al. Effect of Administering a Multi-species Probiotic Mixture On the Changes in Fecal Microbiota and Symptoms of Irritable Bowel Syndrome: a Randomized, Double-blind, Placebo-controlled Trial. J Clin Biochem Nutr. 2015;57(2):129-34. PubMed PMID: 26388670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. AU - Yoon,Hyuk, AU - Park,Young Soo, AU - Lee,Dong Ho, AU - Seo,Jae-Gu, AU - Shin,Cheol Min, AU - Kim,Nayoung, Y1 - 2015/06/30/ PY - 2015/01/27/received PY - 2015/04/02/accepted PY - 2015/9/22/entrez PY - 2015/9/22/pubmed PY - 2015/9/22/medline KW - diarrhea KW - fecal microbiota KW - irritable bowel syndrome KW - probiotics KW - treatment SP - 129 EP - 34 JF - Journal of clinical biochemistry and nutrition JO - J Clin Biochem Nutr VL - 57 IS - 2 N2 - We assessed the effect of multi-species probiotic mixture on the changes in fecal microbiota and irritable bowel syndrome (IBS) symptoms. Eighty-one IBS patients were randomly assigned to receive either probiotic mixture (n = 39; containing Lactobacillus acidophilus, L. rhamnosus, Bifidobacterium breve, B. actis, B. longum, and Streptococcus thermophilus) or placebo (n = 42) for 4 weeks. A questionnaire regarding general symptom relief was administered. The change in total symptom scores (sum of 10 IBS symptoms) and subtotal scores in 4 domains (pain, constipation, diarrhea, and bloating/gas) were evaluated. The change in fecal flora was determined by quantitative real-time PCR. The concentration of probiotic strains significantly increased after ingestion in probiotics group (B. bifidum, p = 0.043; B. lactis, p<0.001; L. acidophilus, p = 0.016; L. rhamnosus, p<0.001). The proportion of patients with adequate symptom relief was higher in probiotics group than in placebo group (74.4% vs 61.9%, p = 0.230). The decrease in total symptom score over time was not significantly different between the groups (p = 0.703). Among subtotal scores of 4 IBS symptom domains, the time effect was significantly different for diarrhea-symptom score between the groups (p = 0.017). A 4-week administration of multi-species probiotic mixture significantly increased the fecal concentration of most probiotic strains and improved diarrhea-symptom scores in IBS patients. SN - 0912-0009 UR - https://www.unboundmedicine.com/medline/citation/26388670/Effect_of_administering_a_multi_species_probiotic_mixture_on_the_changes_in_fecal_microbiota_and_symptoms_of_irritable_bowel_syndrome:_a_randomized_double_blind_placebo_controlled_trial_ L2 - https://dx.doi.org/10.3164/jcbn.15-14 DB - PRIME DP - Unbound Medicine ER -