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Cytotoxin-Associated Gene A-Negative Strains of Helicobacter pylori as a Potential Risk Factor of Pancreatic Cancer: A Meta-Analysis Based on Nested Case-Control Studies.
Pancreas. 2015 Nov; 44(8):1340-4.P

Abstract

OBJECTIVES

Risk of pancreatic cancer between Helicobacter pylori infected and noninfected persons is controversial, and therefore a meta-analysis was performed.

METHODS

PubMed was searched up to September 2014. Only population-based nested case-control studies comparing the serological prevalence of Helicobacter pylori between pancreatic cancer cases and cancer-free controls were eligible. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for pancreatic cancer risk between Helicobacter pylori infected and noninfected persons were estimated.

RESULTS

Five eligible nested case-control studies were included, with 1446 pancreatic cancer cases and 2235 cancer-free controls. On the whole, the proportion of pancreatic cancer cases among those infected with Helicobacter pylori was not significant different from those noninfected (OR, 0.99; 95% CI, 0.65-1.50; P = 0.96). Likewise, seropositivity of cytotoxin-associated gene A (CagA) showed nonsignificant association with pancreatic cancer (OR, 0.92; 95% CI, 0.65-1.30; P = 0.63). The CagA-positive virulent strains of Helicobacter pylori did not increase the risk of pancreatic cancer (OR, 0.97; 95% CI, 0.50-1.89; P = 0.93). However, CagA-negative nonvirulent strains of Helicobacter pylori had a significant increased risk for pancreatic cancer (OR, 1.47; 95% CI, 1.11-1.96; P = 0.008).

CONCLUSIONS

The CagA-negative non-virulent strains of Helicobacter pylori may be a potential risk factor of pancreatic cancer. High-quality prospective large-scaled studies are required for more conclusive results.

Authors+Show Affiliations

From the *Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China; †Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; and ‡Nursing Section, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26390415

Citation

Chen, Xin-Zu, et al. "Cytotoxin-Associated Gene A-Negative Strains of Helicobacter Pylori as a Potential Risk Factor of Pancreatic Cancer: a Meta-Analysis Based On Nested Case-Control Studies." Pancreas, vol. 44, no. 8, 2015, pp. 1340-4.
Chen XZ, Wang R, Chen HN, et al. Cytotoxin-Associated Gene A-Negative Strains of Helicobacter pylori as a Potential Risk Factor of Pancreatic Cancer: A Meta-Analysis Based on Nested Case-Control Studies. Pancreas. 2015;44(8):1340-4.
Chen, X. Z., Wang, R., Chen, H. N., & Hu, J. K. (2015). Cytotoxin-Associated Gene A-Negative Strains of Helicobacter pylori as a Potential Risk Factor of Pancreatic Cancer: A Meta-Analysis Based on Nested Case-Control Studies. Pancreas, 44(8), 1340-4. https://doi.org/10.1097/MPA.0000000000000414
Chen XZ, et al. Cytotoxin-Associated Gene A-Negative Strains of Helicobacter Pylori as a Potential Risk Factor of Pancreatic Cancer: a Meta-Analysis Based On Nested Case-Control Studies. Pancreas. 2015;44(8):1340-4. PubMed PMID: 26390415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxin-Associated Gene A-Negative Strains of Helicobacter pylori as a Potential Risk Factor of Pancreatic Cancer: A Meta-Analysis Based on Nested Case-Control Studies. AU - Chen,Xin-Zu, AU - Wang,Rui, AU - Chen,Hai-Ning, AU - Hu,Jian-Kun, PY - 2015/9/22/entrez PY - 2015/9/22/pubmed PY - 2016/8/2/medline SP - 1340 EP - 4 JF - Pancreas JO - Pancreas VL - 44 IS - 8 N2 - OBJECTIVES: Risk of pancreatic cancer between Helicobacter pylori infected and noninfected persons is controversial, and therefore a meta-analysis was performed. METHODS: PubMed was searched up to September 2014. Only population-based nested case-control studies comparing the serological prevalence of Helicobacter pylori between pancreatic cancer cases and cancer-free controls were eligible. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for pancreatic cancer risk between Helicobacter pylori infected and noninfected persons were estimated. RESULTS: Five eligible nested case-control studies were included, with 1446 pancreatic cancer cases and 2235 cancer-free controls. On the whole, the proportion of pancreatic cancer cases among those infected with Helicobacter pylori was not significant different from those noninfected (OR, 0.99; 95% CI, 0.65-1.50; P = 0.96). Likewise, seropositivity of cytotoxin-associated gene A (CagA) showed nonsignificant association with pancreatic cancer (OR, 0.92; 95% CI, 0.65-1.30; P = 0.63). The CagA-positive virulent strains of Helicobacter pylori did not increase the risk of pancreatic cancer (OR, 0.97; 95% CI, 0.50-1.89; P = 0.93). However, CagA-negative nonvirulent strains of Helicobacter pylori had a significant increased risk for pancreatic cancer (OR, 1.47; 95% CI, 1.11-1.96; P = 0.008). CONCLUSIONS: The CagA-negative non-virulent strains of Helicobacter pylori may be a potential risk factor of pancreatic cancer. High-quality prospective large-scaled studies are required for more conclusive results. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/26390415/Cytotoxin_Associated_Gene_A_Negative_Strains_of_Helicobacter_pylori_as_a_Potential_Risk_Factor_of_Pancreatic_Cancer:_A_Meta_Analysis_Based_on_Nested_Case_Control_Studies_ L2 - https://doi.org/10.1097/MPA.0000000000000414 DB - PRIME DP - Unbound Medicine ER -