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The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing.
Br J Nutr. 2015 Nov 28; 114(10):1542-9.BJ

Abstract

Previously, it has been shown that strawberry (SB) or blueberry (BB) supplementations, when fed to rats from 19 to 21 months of age, reverse age-related decrements in motor and cognitive performance. We have postulated that these effects may be the result of a number of positive benefits of the berry polyphenols, including decreased stress signalling, increased neurogenesis, and increased signals involved in learning and memory. Thus, the present study was carried out to examine these mechanisms in aged animals by administering a control, 2 % SB- or 2 % BB-supplemented diet to aged Fischer 344 rats for 8 weeks to ascertain their effectiveness in reversing age-related deficits in behavioural and neuronal function. The results showed that rats consuming the berry diets exhibited enhanced motor performance and improved cognition, specifically working memory. In addition, the rats supplemented with BB and SB diets showed increased hippocampal neurogenesis and expression of insulin-like growth factor 1, although the improvements in working memory performance could not solely be explained by these increases. The diverse polyphenolics in these berry fruits may have additional mechanisms of action that could account for their relative differences in efficacy.

Authors+Show Affiliations

USDA-ARS, Human Nutrition Research Center on Aging,Tufts University,Boston,MA 02111,USA.USDA-ARS, Human Nutrition Research Center on Aging,Tufts University,Boston,MA 02111,USA.USDA-ARS, Human Nutrition Research Center on Aging,Tufts University,Boston,MA 02111,USA.USDA-ARS, Human Nutrition Research Center on Aging,Tufts University,Boston,MA 02111,USA.USDA-ARS, Human Nutrition Research Center on Aging,Tufts University,Boston,MA 02111,USA.USDA-ARS, Human Nutrition Research Center on Aging,Tufts University,Boston,MA 02111,USA.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

26392037

Citation

Shukitt-Hale, Barbara, et al. "The Beneficial Effects of Berries On Cognition, Motor Behaviour and Neuronal Function in Ageing." The British Journal of Nutrition, vol. 114, no. 10, 2015, pp. 1542-9.
Shukitt-Hale B, Bielinski DF, Lau FC, et al. The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. Br J Nutr. 2015;114(10):1542-9.
Shukitt-Hale, B., Bielinski, D. F., Lau, F. C., Willis, L. M., Carey, A. N., & Joseph, J. A. (2015). The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. The British Journal of Nutrition, 114(10), 1542-9. https://doi.org/10.1017/S0007114515003451
Shukitt-Hale B, et al. The Beneficial Effects of Berries On Cognition, Motor Behaviour and Neuronal Function in Ageing. Br J Nutr. 2015 Nov 28;114(10):1542-9. PubMed PMID: 26392037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. AU - Shukitt-Hale,Barbara, AU - Bielinski,Donna F, AU - Lau,Francis C, AU - Willis,Lauren M, AU - Carey,Amanda N, AU - Joseph,James A, Y1 - 2015/09/22/ PY - 2015/9/23/entrez PY - 2015/9/24/pubmed PY - 2016/2/2/medline KW - BB blueberry KW - Blueberries KW - BrdU bromodeoxyuridine KW - IGF-1 insulin-like growth factor 1 KW - INF inflammation KW - Learning KW - MWM Morris water maze KW - Neurogenesis KW - OS oxidative stress KW - SB strawberry KW - Spatial memory KW - Strawberries KW - Stress signalling KW - TBST Tris-buffered saline with Tween SP - 1542 EP - 9 JF - The British journal of nutrition JO - Br J Nutr VL - 114 IS - 10 N2 - Previously, it has been shown that strawberry (SB) or blueberry (BB) supplementations, when fed to rats from 19 to 21 months of age, reverse age-related decrements in motor and cognitive performance. We have postulated that these effects may be the result of a number of positive benefits of the berry polyphenols, including decreased stress signalling, increased neurogenesis, and increased signals involved in learning and memory. Thus, the present study was carried out to examine these mechanisms in aged animals by administering a control, 2 % SB- or 2 % BB-supplemented diet to aged Fischer 344 rats for 8 weeks to ascertain their effectiveness in reversing age-related deficits in behavioural and neuronal function. The results showed that rats consuming the berry diets exhibited enhanced motor performance and improved cognition, specifically working memory. In addition, the rats supplemented with BB and SB diets showed increased hippocampal neurogenesis and expression of insulin-like growth factor 1, although the improvements in working memory performance could not solely be explained by these increases. The diverse polyphenolics in these berry fruits may have additional mechanisms of action that could account for their relative differences in efficacy. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/26392037/The_beneficial_effects_of_berries_on_cognition_motor_behaviour_and_neuronal_function_in_ageing_ L2 - https://www.cambridge.org/core/product/identifier/S0007114515003451/type/journal_article DB - PRIME DP - Unbound Medicine ER -