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High Sensitivity and High Detection Specificity of Gold-Nanoparticle-Grafted Nanostructured Silicon Mass Spectrometry for Glucose Analysis.
ACS Appl Mater Interfaces. 2015 Oct 14; 7(40):22630-7.AA

Abstract

Desorption/ionization on silicon (DIOS) is a high-performance matrix-free mass spectrometry (MS) analysis method that involves using silicon nanostructures as a matrix for MS desorption/ionization. In this study, gold nanoparticles grafted onto a nanostructured silicon (AuNPs-nSi) surface were demonstrated as a DIOS-MS analysis approach with high sensitivity and high detection specificity for glucose detection. A glucose sample deposited on the AuNPs-nSi surface was directly catalyzed to negatively charged gluconic acid molecules on a single AuNPs-nSi chip for MS analysis. The AuNPs-nSi surface was fabricated using two electroless deposition steps and one electroless etching step. The effects of the electroless fabrication parameters on the glucose detection efficiency were evaluated. Practical application of AuNPs-nSi MS glucose analysis in urine samples was also demonstrated in this study.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Tsao CW
Department of Mechanical Engineering, National Central University , Taoyuan City 32001, Taiwan.
Yang ZJ
Department of Mechanical Engineering, National Central University , Taoyuan City 32001, Taiwan.

MeSH

GlucoseGoldHumansMetal NanoparticlesNanostructuresSiliconSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26393877

Citation

Tsao, Chia-Wen, and Zhi-Jie Yang. "High Sensitivity and High Detection Specificity of Gold-Nanoparticle-Grafted Nanostructured Silicon Mass Spectrometry for Glucose Analysis." ACS Applied Materials & Interfaces, vol. 7, no. 40, 2015, pp. 22630-7.
Tsao CW, Yang ZJ. High Sensitivity and High Detection Specificity of Gold-Nanoparticle-Grafted Nanostructured Silicon Mass Spectrometry for Glucose Analysis. ACS Appl Mater Interfaces. 2015;7(40):22630-7.
Tsao, C. W., & Yang, Z. J. (2015). High Sensitivity and High Detection Specificity of Gold-Nanoparticle-Grafted Nanostructured Silicon Mass Spectrometry for Glucose Analysis. ACS Applied Materials & Interfaces, 7(40), 22630-7. https://doi.org/10.1021/acsami.5b07395
Tsao CW, Yang ZJ. High Sensitivity and High Detection Specificity of Gold-Nanoparticle-Grafted Nanostructured Silicon Mass Spectrometry for Glucose Analysis. ACS Appl Mater Interfaces. 2015 Oct 14;7(40):22630-7. PubMed PMID: 26393877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High Sensitivity and High Detection Specificity of Gold-Nanoparticle-Grafted Nanostructured Silicon Mass Spectrometry for Glucose Analysis. AU - Tsao,Chia-Wen, AU - Yang,Zhi-Jie, Y1 - 2015/09/30/ PY - 2015/9/23/entrez PY - 2015/9/24/pubmed PY - 2016/8/6/medline KW - desorption/ionization on silicon KW - glucose analysis KW - mass spectrometry KW - matrix-free laser desorption/ionization KW - nanostructured silicon SP - 22630 EP - 7 JF - ACS applied materials & interfaces JO - ACS Appl Mater Interfaces VL - 7 IS - 40 N2 - Desorption/ionization on silicon (DIOS) is a high-performance matrix-free mass spectrometry (MS) analysis method that involves using silicon nanostructures as a matrix for MS desorption/ionization. In this study, gold nanoparticles grafted onto a nanostructured silicon (AuNPs-nSi) surface were demonstrated as a DIOS-MS analysis approach with high sensitivity and high detection specificity for glucose detection. A glucose sample deposited on the AuNPs-nSi surface was directly catalyzed to negatively charged gluconic acid molecules on a single AuNPs-nSi chip for MS analysis. The AuNPs-nSi surface was fabricated using two electroless deposition steps and one electroless etching step. The effects of the electroless fabrication parameters on the glucose detection efficiency were evaluated. Practical application of AuNPs-nSi MS glucose analysis in urine samples was also demonstrated in this study. SN - 1944-8252 UR - https://www.unboundmedicine.com/medline/citation/26393877/High_Sensitivity_and_High_Detection_Specificity_of_Gold_Nanoparticle_Grafted_Nanostructured_Silicon_Mass_Spectrometry_for_Glucose_Analysis_ DB - PRIME DP - Unbound Medicine ER -