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DNA damage and oxidative stress induced by imidacloprid exposure in the earthworm Eisenia fetida.
Chemosphere. 2016 Feb; 144:510-7.C

Abstract

To investigate the soil ecological effect of imidacloprid, earthworm Eisenia fetida was exposed to various concentrations of imidacloprid (0.10, 0.50, and 1.00 mg kg(-1) soil) respectively after 7, 14, 21, and 28 d. The effect of imidacloprid on reactive oxygen species (ROS) generation, antioxidant enzymes activity [superoxide dismutase (SOD) and catalase (CAT), glutathione S-transferase enzyme (GST)], malondialdehyde (MDA) content and DNA damage of the E. fetida was investigated. Significant increase of the ROS level was observed. The SOD and GST activity were significantly induced at most exposure intervals. CAT activity was inhibited and reflected a dose-dependent relationship on days 7, 14 and 21. High MDA levels were observed and the olive tail moment (OTM) as well as the percentage of DNA in the comet tail (tail DNA%) in comet assay declined with increasing concentrations and exposure time after 7 d. Our results suggested that the sub-chronic exposure of imidacloprid caused DNA damage and lipid peroxidation (LPO) leading to antioxidant responses in earthworm E. fetida.

Authors+Show Affiliations

National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Taian, 271018, People's Republic of China.National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Taian, 271018, People's Republic of China. Electronic address: wjh@sdau.edu.cn.National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Taian, 271018, People's Republic of China.National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Taian, 271018, People's Republic of China.National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Taian, 271018, People's Republic of China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26397468

Citation

Wang, Juan, et al. "DNA Damage and Oxidative Stress Induced By Imidacloprid Exposure in the Earthworm Eisenia Fetida." Chemosphere, vol. 144, 2016, pp. 510-7.
Wang J, Wang J, Wang G, et al. DNA damage and oxidative stress induced by imidacloprid exposure in the earthworm Eisenia fetida. Chemosphere. 2016;144:510-7.
Wang, J., Wang, J., Wang, G., Zhu, L., & Wang, J. (2016). DNA damage and oxidative stress induced by imidacloprid exposure in the earthworm Eisenia fetida. Chemosphere, 144, 510-7. https://doi.org/10.1016/j.chemosphere.2015.09.004
Wang J, et al. DNA Damage and Oxidative Stress Induced By Imidacloprid Exposure in the Earthworm Eisenia Fetida. Chemosphere. 2016;144:510-7. PubMed PMID: 26397468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DNA damage and oxidative stress induced by imidacloprid exposure in the earthworm Eisenia fetida. AU - Wang,Juan, AU - Wang,Jinhua, AU - Wang,Guangchi, AU - Zhu,Lusheng, AU - Wang,Jun, Y1 - 2015/09/19/ PY - 2015/04/09/received PY - 2015/08/31/revised PY - 2015/09/01/accepted PY - 2015/9/24/entrez PY - 2015/9/24/pubmed PY - 2016/9/9/medline KW - DNA damage KW - Eisenia fetida KW - Imidacloprid KW - Lipid peroxidation KW - Oxidative stress SP - 510 EP - 7 JF - Chemosphere JO - Chemosphere VL - 144 N2 - To investigate the soil ecological effect of imidacloprid, earthworm Eisenia fetida was exposed to various concentrations of imidacloprid (0.10, 0.50, and 1.00 mg kg(-1) soil) respectively after 7, 14, 21, and 28 d. The effect of imidacloprid on reactive oxygen species (ROS) generation, antioxidant enzymes activity [superoxide dismutase (SOD) and catalase (CAT), glutathione S-transferase enzyme (GST)], malondialdehyde (MDA) content and DNA damage of the E. fetida was investigated. Significant increase of the ROS level was observed. The SOD and GST activity were significantly induced at most exposure intervals. CAT activity was inhibited and reflected a dose-dependent relationship on days 7, 14 and 21. High MDA levels were observed and the olive tail moment (OTM) as well as the percentage of DNA in the comet tail (tail DNA%) in comet assay declined with increasing concentrations and exposure time after 7 d. Our results suggested that the sub-chronic exposure of imidacloprid caused DNA damage and lipid peroxidation (LPO) leading to antioxidant responses in earthworm E. fetida. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/26397468/DNA_damage_and_oxidative_stress_induced_by_imidacloprid_exposure_in_the_earthworm_Eisenia_fetida_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-6535(15)30091-6 DB - PRIME DP - Unbound Medicine ER -