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Self-Rated Health in Healthy Adults and Susceptibility to the Common Cold.
Psychosom Med 2015 Nov-Dec; 77(9):959-68PM

Abstract

OBJECTIVES

To explore the association of self-rated health (SRH) with host resistance to illness after exposure to a common cold virus and identify mechanisms linking SRH to future health status.

METHODS

We analyzed archival data from 360 healthy adults (mean [standard deviation] age = 33.07 [10.69] years, 45.6% women). Each person completed validated questionnaires that assessed SRH (excellent, very good, good, fair, poor), socioemotional factors, and health practices and was subsequently exposed to a common cold virus and monitored for 5 days for clinical illness (infection and objective signs of illness).

RESULTS

Poorer SRH was associated in a graded fashion with greater susceptibility to developing clinical illness (good/fair versus excellent: odds ratio = 3.21, 95% confidence interval = 1.47-6.99; very good versus excellent: odds ratio = 2.60, 95% confidence interval = 1.27-5.32), independent of age, sex, race, prechallenge immunity (specific antibody), body mass, season, education, and income. Greater illness risk was not attributable to infection, but to increased likelihood of developing objective signs of illness once infected. Poorer SRH also correlated with poorer health practices, increased stress, lower positive emotions, and other socioemotional factors. However, none of these (alone or together) accounted for the association between SRH and host resistance. Additional data (separate study) indicated that history of having colds was unrelated to susceptibility and hence also did not account for the SRH link with immunocompetence.

CONCLUSIONS

Poorer SRH is associated with poorer immunocompetence, possibly reflecting sensitivity to sensations associated with premorbid immune dysfunction. In turn, poorer immune function may be a major contributing mechanism linking SRH to future health.

Authors+Show Affiliations

From the Department of Psychology (Cohen and Janicki-Deverts), Carnegie Mellon University, Pittsburgh, Pennsylvania; and Department of Otolaryngology/ENT (Doyle), Children's Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26397938

Citation

Cohen, Sheldon, et al. "Self-Rated Health in Healthy Adults and Susceptibility to the Common Cold." Psychosomatic Medicine, vol. 77, no. 9, 2015, pp. 959-68.
Cohen S, Janicki-Deverts D, Doyle WJ. Self-Rated Health in Healthy Adults and Susceptibility to the Common Cold. Psychosom Med. 2015;77(9):959-68.
Cohen, S., Janicki-Deverts, D., & Doyle, W. J. (2015). Self-Rated Health in Healthy Adults and Susceptibility to the Common Cold. Psychosomatic Medicine, 77(9), pp. 959-68. doi:10.1097/PSY.0000000000000232.
Cohen S, Janicki-Deverts D, Doyle WJ. Self-Rated Health in Healthy Adults and Susceptibility to the Common Cold. Psychosom Med. 2015;77(9):959-68. PubMed PMID: 26397938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Self-Rated Health in Healthy Adults and Susceptibility to the Common Cold. AU - Cohen,Sheldon, AU - Janicki-Deverts,Denise, AU - Doyle,William J, PY - 2015/9/24/entrez PY - 2015/9/24/pubmed PY - 2016/9/2/medline SP - 959 EP - 68 JF - Psychosomatic medicine JO - Psychosom Med VL - 77 IS - 9 N2 - OBJECTIVES: To explore the association of self-rated health (SRH) with host resistance to illness after exposure to a common cold virus and identify mechanisms linking SRH to future health status. METHODS: We analyzed archival data from 360 healthy adults (mean [standard deviation] age = 33.07 [10.69] years, 45.6% women). Each person completed validated questionnaires that assessed SRH (excellent, very good, good, fair, poor), socioemotional factors, and health practices and was subsequently exposed to a common cold virus and monitored for 5 days for clinical illness (infection and objective signs of illness). RESULTS: Poorer SRH was associated in a graded fashion with greater susceptibility to developing clinical illness (good/fair versus excellent: odds ratio = 3.21, 95% confidence interval = 1.47-6.99; very good versus excellent: odds ratio = 2.60, 95% confidence interval = 1.27-5.32), independent of age, sex, race, prechallenge immunity (specific antibody), body mass, season, education, and income. Greater illness risk was not attributable to infection, but to increased likelihood of developing objective signs of illness once infected. Poorer SRH also correlated with poorer health practices, increased stress, lower positive emotions, and other socioemotional factors. However, none of these (alone or together) accounted for the association between SRH and host resistance. Additional data (separate study) indicated that history of having colds was unrelated to susceptibility and hence also did not account for the SRH link with immunocompetence. CONCLUSIONS: Poorer SRH is associated with poorer immunocompetence, possibly reflecting sensitivity to sensations associated with premorbid immune dysfunction. In turn, poorer immune function may be a major contributing mechanism linking SRH to future health. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/26397938/Self_Rated_Health_in_Healthy_Adults_and_Susceptibility_to_the_Common_Cold_ L2 - http://Insights.ovid.com/pubmed?pmid=26397938 DB - PRIME DP - Unbound Medicine ER -