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Risk stratification of coronary artery disease in asymptomatic diabetic subjects using multidetector computed tomography.
Circ J. 2015; 79(11):2422-9.CJ

Abstract

BACKGROUND

Patients with type 2 diabetes mellitus (T2DM) show a greater risk for coronary artery disease (CAD), but the risk stratification in asymptomatic CAD patients has not been established. This study investigated the prevalence and severity for asymptomatic CAD and predictors in T2DM patients.

METHODS AND RESULTS

In a multiclinic group, diabetic patients (320 men, 186 women) without known symptoms suggestive of CAD were recruited for multidetector computed tomography (MDCT). Patients were categorized according to severity of coronary atherosclerosis: Grade 1 (normal findings), Grade 2 (mild atherosclerosis without significant stenosis), Grade 3 (moderate stenosis/atherosclerosis, 50-74% stenosis), Grade 4 (moderate stenosis/atherosclerosis, 75-89% stenosis), Grade 5 (severe stenosis/atherosclerosis, ≥90% stenosis). The trend for severity grade of CAD was slightly higher in men than women (P=0.054). For critical lesions (combined Grades 3-5), the prevalence was almost equal (men 44% vs. women 37%; P=0.113). Multivariate models showed that in men, HbA1c≥7.4%, dyslipidemia, duration of diabetes, retinopathy, and other type of cardiovascular diseases were predictors of critical lesions and in women, duration of diabetes and retinopathy were predictors.

CONCLUSIONS

The prevalence and severity of asymptomatic CAD are comparably high in men and women with T2DM. Risk stratification by using MDCT might be useful to predict asymptomatic coronary lesions requiring coronary revascularization.

Authors+Show Affiliations

Department of Cardio-Diabetes Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26399764

Citation

Shimabukuro, Michio, et al. "Risk Stratification of Coronary Artery Disease in Asymptomatic Diabetic Subjects Using Multidetector Computed Tomography." Circulation Journal : Official Journal of the Japanese Circulation Society, vol. 79, no. 11, 2015, pp. 2422-9.
Shimabukuro M, Saito T, Higa T, et al. Risk stratification of coronary artery disease in asymptomatic diabetic subjects using multidetector computed tomography. Circ J. 2015;79(11):2422-9.
Shimabukuro, M., Saito, T., Higa, T., Nakamura, K., Masuzaki, H., & Sata, M. (2015). Risk stratification of coronary artery disease in asymptomatic diabetic subjects using multidetector computed tomography. Circulation Journal : Official Journal of the Japanese Circulation Society, 79(11), 2422-9. https://doi.org/10.1253/circj.CJ-15-0325
Shimabukuro M, et al. Risk Stratification of Coronary Artery Disease in Asymptomatic Diabetic Subjects Using Multidetector Computed Tomography. Circ J. 2015;79(11):2422-9. PubMed PMID: 26399764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk stratification of coronary artery disease in asymptomatic diabetic subjects using multidetector computed tomography. AU - Shimabukuro,Michio, AU - Saito,Taro, AU - Higa,Toru, AU - Nakamura,Keita, AU - Masuzaki,Hiroaki, AU - Sata,Masataka, AU - ,, Y1 - 2015/09/18/ PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2016/8/12/medline SP - 2422 EP - 9 JF - Circulation journal : official journal of the Japanese Circulation Society JO - Circ J VL - 79 IS - 11 N2 - BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) show a greater risk for coronary artery disease (CAD), but the risk stratification in asymptomatic CAD patients has not been established. This study investigated the prevalence and severity for asymptomatic CAD and predictors in T2DM patients. METHODS AND RESULTS: In a multiclinic group, diabetic patients (320 men, 186 women) without known symptoms suggestive of CAD were recruited for multidetector computed tomography (MDCT). Patients were categorized according to severity of coronary atherosclerosis: Grade 1 (normal findings), Grade 2 (mild atherosclerosis without significant stenosis), Grade 3 (moderate stenosis/atherosclerosis, 50-74% stenosis), Grade 4 (moderate stenosis/atherosclerosis, 75-89% stenosis), Grade 5 (severe stenosis/atherosclerosis, ≥90% stenosis). The trend for severity grade of CAD was slightly higher in men than women (P=0.054). For critical lesions (combined Grades 3-5), the prevalence was almost equal (men 44% vs. women 37%; P=0.113). Multivariate models showed that in men, HbA1c≥7.4%, dyslipidemia, duration of diabetes, retinopathy, and other type of cardiovascular diseases were predictors of critical lesions and in women, duration of diabetes and retinopathy were predictors. CONCLUSIONS: The prevalence and severity of asymptomatic CAD are comparably high in men and women with T2DM. Risk stratification by using MDCT might be useful to predict asymptomatic coronary lesions requiring coronary revascularization. SN - 1347-4820 UR - https://www.unboundmedicine.com/medline/citation/26399764/Risk_stratification_of_coronary_artery_disease_in_asymptomatic_diabetic_subjects_using_multidetector_computed_tomography_ L2 - https://dx.doi.org/10.1253/circj.CJ-15-0325 DB - PRIME DP - Unbound Medicine ER -