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Anti-inflammatory Diets.
J Am Coll Nutr 2015; 34 Suppl 1:14-21JA

Abstract

Chronic disease is driven by inflammation. This article will provide an overview on how the balance of macronutrients and omega-6 and omega-3 fatty acids in the diet can alter the expression of inflammatory genes. In particular, how the balance of the protein to glycemic load of a meal can alter the generation of insulin and glucagon and the how the balance of omega-6 and omega-3 fatty acids can effect eicosanoid formation. Clinical results on the reduction of inflammation following anti-inflammatory diets are discussed as well as the molecular targets of anti-inflammatory nutrition. To overcome silent inflammation requires an anti-inflammatory diet (with omega-3s and polyphenols, in particular those of Maqui). The most important aspect of such an anti-inflammatory diet is the stabilization of insulin and reduced intake of omega-6 fatty acids. The ultimate treatment lies in reestablishing hormonal and genetic balance to generate satiety instead of constant hunger. Anti-inflammatory nutrition, balanced 40:30:30 with caloric restriction, should be considered as a form of gene silencing technology, in particular the silencing of the genes involved in the generation of silent inflammation. To this anti-inflammatory diet foundation supplemental omega-3 fatty acids at the level of 2-3 g of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) per day should be added. Finally, a diet rich in colorful, nonstarchy vegetables would contribute adequate amounts of polyphenols to help not only to inhibit nuclear factor (NF)-κB (primary molecular target of inflammation) but also activate AMP kinase. Understanding the impact of an anti-inflammatory diet on silent inflammation can elevate the diet from simply a source of calories to being on the cutting edge of gene-silencing technology.

Authors+Show Affiliations

a Inflammation Research Foundation , Marblehead , Massachusetts.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26400429

Citation

Sears, Barry. "Anti-inflammatory Diets." Journal of the American College of Nutrition, vol. 34 Suppl 1, 2015, pp. 14-21.
Sears B. Anti-inflammatory Diets. J Am Coll Nutr. 2015;34 Suppl 1:14-21.
Sears, B. (2015). Anti-inflammatory Diets. Journal of the American College of Nutrition, 34 Suppl 1, pp. 14-21. doi:10.1080/07315724.2015.1080105.
Sears B. Anti-inflammatory Diets. J Am Coll Nutr. 2015;34 Suppl 1:14-21. PubMed PMID: 26400429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory Diets. A1 - Sears,Barry, PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2016/7/7/medline KW - AA/EPA ratio KW - HbA1c KW - TG/HDL ratio KW - anti-inflammatory diet KW - metabolic syndrome KW - omega-3 fatty acids KW - polyphenols SP - 14 EP - 21 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 34 Suppl 1 N2 - Chronic disease is driven by inflammation. This article will provide an overview on how the balance of macronutrients and omega-6 and omega-3 fatty acids in the diet can alter the expression of inflammatory genes. In particular, how the balance of the protein to glycemic load of a meal can alter the generation of insulin and glucagon and the how the balance of omega-6 and omega-3 fatty acids can effect eicosanoid formation. Clinical results on the reduction of inflammation following anti-inflammatory diets are discussed as well as the molecular targets of anti-inflammatory nutrition. To overcome silent inflammation requires an anti-inflammatory diet (with omega-3s and polyphenols, in particular those of Maqui). The most important aspect of such an anti-inflammatory diet is the stabilization of insulin and reduced intake of omega-6 fatty acids. The ultimate treatment lies in reestablishing hormonal and genetic balance to generate satiety instead of constant hunger. Anti-inflammatory nutrition, balanced 40:30:30 with caloric restriction, should be considered as a form of gene silencing technology, in particular the silencing of the genes involved in the generation of silent inflammation. To this anti-inflammatory diet foundation supplemental omega-3 fatty acids at the level of 2-3 g of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) per day should be added. Finally, a diet rich in colorful, nonstarchy vegetables would contribute adequate amounts of polyphenols to help not only to inhibit nuclear factor (NF)-κB (primary molecular target of inflammation) but also activate AMP kinase. Understanding the impact of an anti-inflammatory diet on silent inflammation can elevate the diet from simply a source of calories to being on the cutting edge of gene-silencing technology. SN - 1541-1087 UR - https://www.unboundmedicine.com/medline/citation/26400429/Anti_inflammatory_Diets_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.2015.1080105 DB - PRIME DP - Unbound Medicine ER -