Tags

Type your tag names separated by a space and hit enter

Mitigation of Inflammation-Induced Mood Dysregulation by Long-Chain Omega-3 Fatty Acids.
J Am Coll Nutr 2015; 34 Suppl 1:48-55JA

Abstract

Although evidence suggests that chronic elevations in immune-inflammatory signaling can precipitate mood symptoms in a subset of individuals, associated risk and resilience mechanisms remain poorly understood. Long-chain omega-3 (LCn-3) fatty acids, including eicosapentaenic acid (EPA) and docosahexaenoic acid (DHA), have anti-inflammatory and inflammation-resolving properties that maintain immune-inflammatory signaling homeostasis. Cross-sectional evidence suggests that the mood disorders major depressive disorder and bipolar disorder are associated with low EPA and/or DHA biostatus, elevations in the LCn-6:LCn-3 fatty acid ratio, and elevated levels of pro-inflammatory eicosanoids, cytokines, and acute-phase proteins. Medications that are effective for reducing depressive symptoms or stabilizing manic depressive oscillations may act in part by downregulating immune-inflammatory signaling and are augmented by anti-inflammatory medications. Recent prospective longitudinal evidence suggests that elevations in the LCn-6:LCn-3 fatty acid ratio are a modifiable risk factor for the development of mood symptoms, including depression and irritability, in response to immune-inflammatory signaling. Together these data suggest that increasing LCn-3 fatty acid intake and biostatus represents a feasible strategy to mitigate the negative impact of elevated immune-inflammatory signaling on mood stability. Key teaching points: • Long-chain omega-3 (LCn-3) fatty acids have anti-inflammatory and inflammation-resolving properties. • Major mood disorders are associated with both LCn-3 fatty acids deficiency and elevated immune-inflammatory signaling. • Prospective evidence suggests that low LCn-3 fatty acid biostatus increases risk for developing inflammation-induced mood dysregulation. • Taken collectively, this evidence suggests that increasing LCn-3 fatty acid intake and biostatus represents a promising strategy to mitigate the detrimental effects of elevated immune-inflammatory signaling on mood.

Authors+Show Affiliations

a Department of Psychiatry and Behavioral Neuroscience , Division of Bipolar Disorders Research, University of Cincinnati College of Medicine , Cincinnati , Ohio.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26400435

Citation

McNamara, Robert K.. "Mitigation of Inflammation-Induced Mood Dysregulation By Long-Chain Omega-3 Fatty Acids." Journal of the American College of Nutrition, vol. 34 Suppl 1, 2015, pp. 48-55.
McNamara RK. Mitigation of Inflammation-Induced Mood Dysregulation by Long-Chain Omega-3 Fatty Acids. J Am Coll Nutr. 2015;34 Suppl 1:48-55.
McNamara, R. K. (2015). Mitigation of Inflammation-Induced Mood Dysregulation by Long-Chain Omega-3 Fatty Acids. Journal of the American College of Nutrition, 34 Suppl 1, pp. 48-55. doi:10.1080/07315724.2015.1080527.
McNamara RK. Mitigation of Inflammation-Induced Mood Dysregulation By Long-Chain Omega-3 Fatty Acids. J Am Coll Nutr. 2015;34 Suppl 1:48-55. PubMed PMID: 26400435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitigation of Inflammation-Induced Mood Dysregulation by Long-Chain Omega-3 Fatty Acids. A1 - McNamara,Robert K, PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2016/7/7/medline KW - arachidonic acid KW - bipolar disorder KW - cytokines KW - depression KW - docosahexaenoic acid (DHA) KW - inflammation KW - mood KW - omega-3 fatty acids SP - 48 EP - 55 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 34 Suppl 1 N2 - Although evidence suggests that chronic elevations in immune-inflammatory signaling can precipitate mood symptoms in a subset of individuals, associated risk and resilience mechanisms remain poorly understood. Long-chain omega-3 (LCn-3) fatty acids, including eicosapentaenic acid (EPA) and docosahexaenoic acid (DHA), have anti-inflammatory and inflammation-resolving properties that maintain immune-inflammatory signaling homeostasis. Cross-sectional evidence suggests that the mood disorders major depressive disorder and bipolar disorder are associated with low EPA and/or DHA biostatus, elevations in the LCn-6:LCn-3 fatty acid ratio, and elevated levels of pro-inflammatory eicosanoids, cytokines, and acute-phase proteins. Medications that are effective for reducing depressive symptoms or stabilizing manic depressive oscillations may act in part by downregulating immune-inflammatory signaling and are augmented by anti-inflammatory medications. Recent prospective longitudinal evidence suggests that elevations in the LCn-6:LCn-3 fatty acid ratio are a modifiable risk factor for the development of mood symptoms, including depression and irritability, in response to immune-inflammatory signaling. Together these data suggest that increasing LCn-3 fatty acid intake and biostatus represents a feasible strategy to mitigate the negative impact of elevated immune-inflammatory signaling on mood stability. Key teaching points: • Long-chain omega-3 (LCn-3) fatty acids have anti-inflammatory and inflammation-resolving properties. • Major mood disorders are associated with both LCn-3 fatty acids deficiency and elevated immune-inflammatory signaling. • Prospective evidence suggests that low LCn-3 fatty acid biostatus increases risk for developing inflammation-induced mood dysregulation. • Taken collectively, this evidence suggests that increasing LCn-3 fatty acid intake and biostatus represents a promising strategy to mitigate the detrimental effects of elevated immune-inflammatory signaling on mood. SN - 1541-1087 UR - https://www.unboundmedicine.com/medline/citation/26400435/Mitigation_of_Inflammation_Induced_Mood_Dysregulation_by_Long_Chain_Omega_3_Fatty_Acids_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.2015.1080527 DB - PRIME DP - Unbound Medicine ER -