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Long-Term Alcohol Consumption and Breast, Upper Aero-Digestive Tract and Colorectal Cancer Risk: A Systematic Review and Meta-Analysis.
Alcohol Alcohol 2016; 51(3):315-30AA

Abstract

AIMS

Cancers of female breast, upper aero-digestive tract (UADT) (oral cavity, pharynx, larynx, oesophagus) and colorectum are causally related to alcohol consumption. Although alcohol consumption is likely to vary during life, the few studies that have explicitly measured lifetime consumption or intake over time have not been summarised. We therefore conducted a systematic review and meta-analysis.

METHODS

Studies were identified by searching the Medline, CINAHL (Cumulative Index to Nursing and Allied Health Literature) and Scopus databases through January 2015 using broad search criteria. Studies reporting relative risks (RR) for quantitatively defined categories of alcohol consumption over time for breast, UADT or colorectal cancer were eligible. A two-stage random-effects meta-analysis was used to estimate a dose-response relationship between alcohol intake and each cancer site. RRs were also calculated for the highest relative to the lowest intake category.

RESULTS

Sixteen articles for breast, 16 for UADT and 7 for colorectal cancer met the eligibility criteria. We observed a weak non-linear dose-response relationship for breast cancer and positive linear dose-response relationships for UADT and colorectal cancer. The pooled RRs were 1.28 (95% confidence interval, CI: 1.07, 1.52) for breast, 2.83 (95% CI: 1.73, 4.62) for UADT, 4.84 (95% CI: 2.51, 9.32) for oral cavity and pharynx, 2.25 (95% CI: 1.49, 3.42) for larynx, 6.71 (95% CI: 4.21, 10.70) for oesophageal and 1.49 (95% CI: 1.27, 1.74) for colorectal cancer.

CONCLUSION

Our findings confirm dose-dependent associations between long-term alcohol intake and breast, UADT and colorectal cancer.

Authors+Show Affiliations

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, Victoria 3010, Australia Population Health, Murdoch Childrens Research Institute, Flemington Road, Parkville, Victoria 3052, Australia harindra_jaya@yahoo.com.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, Victoria 3010, Australia Cancer Epidemiology Centre, Cancer Council Victoria, 615 St Kilda Rd, Melbourne, Victoria 3004, Australia.Centre for Alcohol Policy Research, La Trobe University, 215 Franklin St., Melbourne, Victoria 3000, Australia Centre for Health Equity, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, Victoria 3010, Australia Centre for Social Research on Alcohol and Drugs, Stockholm University, SE - 106 91 Stockholm, Sweden.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, Victoria 3010, Australia Cancer Epidemiology Centre, Cancer Council Victoria, 615 St Kilda Rd, Melbourne, Victoria 3004, Australia.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

26400678

Citation

Jayasekara, Harindra, et al. "Long-Term Alcohol Consumption and Breast, Upper Aero-Digestive Tract and Colorectal Cancer Risk: a Systematic Review and Meta-Analysis." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 51, no. 3, 2016, pp. 315-30.
Jayasekara H, MacInnis RJ, Room R, et al. Long-Term Alcohol Consumption and Breast, Upper Aero-Digestive Tract and Colorectal Cancer Risk: A Systematic Review and Meta-Analysis. Alcohol Alcohol. 2016;51(3):315-30.
Jayasekara, H., MacInnis, R. J., Room, R., & English, D. R. (2016). Long-Term Alcohol Consumption and Breast, Upper Aero-Digestive Tract and Colorectal Cancer Risk: A Systematic Review and Meta-Analysis. Alcohol and Alcoholism (Oxford, Oxfordshire), 51(3), pp. 315-30. doi:10.1093/alcalc/agv110.
Jayasekara H, et al. Long-Term Alcohol Consumption and Breast, Upper Aero-Digestive Tract and Colorectal Cancer Risk: a Systematic Review and Meta-Analysis. Alcohol Alcohol. 2016;51(3):315-30. PubMed PMID: 26400678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-Term Alcohol Consumption and Breast, Upper Aero-Digestive Tract and Colorectal Cancer Risk: A Systematic Review and Meta-Analysis. AU - Jayasekara,Harindra, AU - MacInnis,Robert J, AU - Room,Robin, AU - English,Dallas R, Y1 - 2015/09/22/ PY - 2015/04/09/received PY - 2015/08/18/accepted PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2017/1/5/medline SP - 315 EP - 30 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol. VL - 51 IS - 3 N2 - AIMS: Cancers of female breast, upper aero-digestive tract (UADT) (oral cavity, pharynx, larynx, oesophagus) and colorectum are causally related to alcohol consumption. Although alcohol consumption is likely to vary during life, the few studies that have explicitly measured lifetime consumption or intake over time have not been summarised. We therefore conducted a systematic review and meta-analysis. METHODS: Studies were identified by searching the Medline, CINAHL (Cumulative Index to Nursing and Allied Health Literature) and Scopus databases through January 2015 using broad search criteria. Studies reporting relative risks (RR) for quantitatively defined categories of alcohol consumption over time for breast, UADT or colorectal cancer were eligible. A two-stage random-effects meta-analysis was used to estimate a dose-response relationship between alcohol intake and each cancer site. RRs were also calculated for the highest relative to the lowest intake category. RESULTS: Sixteen articles for breast, 16 for UADT and 7 for colorectal cancer met the eligibility criteria. We observed a weak non-linear dose-response relationship for breast cancer and positive linear dose-response relationships for UADT and colorectal cancer. The pooled RRs were 1.28 (95% confidence interval, CI: 1.07, 1.52) for breast, 2.83 (95% CI: 1.73, 4.62) for UADT, 4.84 (95% CI: 2.51, 9.32) for oral cavity and pharynx, 2.25 (95% CI: 1.49, 3.42) for larynx, 6.71 (95% CI: 4.21, 10.70) for oesophageal and 1.49 (95% CI: 1.27, 1.74) for colorectal cancer. CONCLUSION: Our findings confirm dose-dependent associations between long-term alcohol intake and breast, UADT and colorectal cancer. SN - 1464-3502 UR - https://www.unboundmedicine.com/medline/citation/26400678/Long_Term_Alcohol_Consumption_and_Breast_Upper_Aero_Digestive_Tract_and_Colorectal_Cancer_Risk:_A_Systematic_Review_and_Meta_Analysis_ L2 - https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/agv110 DB - PRIME DP - Unbound Medicine ER -